Modulation of lipid peroxidation by dietary components

Sujatha, Rani; Srinivas, Leela

doi:10.1016/0887-2333(95)00005-s

Cited by 22 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results demonstrate that lipid peroxidation and oxysterols formation could be effectively inhibited by coriander and white mustard polyphenols. These results are in agreement with Sujatha and Srinivas study (), who examined water extracts of several spices and vegetables against lipid peroxidation (TBARS assay) in human erythrocyte membranes. Coriander seeds and black mustard ( Brassica nigra ) extracts were among the tested solutions.…”

Section: Discussionsupporting

confidence: 91%

Effect of biologically active substances present in water extracts of white mustard and coriander on antioxidant status and lipid peroxidation of mouse C2C12 skeletal muscle cells

Zielniok

Szkoda

Gajewska

et al. 2015

Animal Physiology Nutrition

View full text Add to dashboard Cite

Coriander and white mustard, an annual plants originated in the Mediterranean region, have been cultivated and used as spices for a long time. Recent studies have shown that they may constitute a potential source of phenolic compounds. The aim of this study was to evaluate the content of polyphenols in coriander and white mustard water extracts and to investigate their antioxidant activity in C2C12 mouse skeletal muscle cells, which serve as a good model of cells with intensive metabolism. HPLC analysis showed that polyphenols were able to permeate from the water extracts of studied plants into the undifferentiated myoblasts as well as myocytes undergoing differentiation, increasing the concentration of reduced glutathione and upregulating glutathione reductase and peroxidase activity. White mustard and coriander extracts also decreased the levels of oxysterols and sum of tiobarbituric acid reactive substances (TBARS) in both: myoblasts and differentiating myocytes, demonstrating protective effect on cell membranes. The obtained results indicate that polyphenols synthesized by both herbs may have beneficial effects on muscle tissue.

show abstract

Section: Discussionsupporting

confidence: 91%

Effect of biologically active substances present in water extracts of white mustard and coriander on antioxidant status and lipid peroxidation of mouse C2C12 skeletal muscle cells

Zielniok

Szkoda

Gajewska

et al. 2015

Animal Physiology Nutrition

View full text Add to dashboard Cite

show abstract

“…Extracts of some spices have also shown radiation dose modifying properties (Sharma and others 2000). Spices are also known to possess antioxidant activity (Sujatha and Srinivas 1995). Nevertheless, to date, no aflatoxin inactivating activity of these extracts has been reported.…”

Section: And and And And Amentioning

confidence: 99%

Aflatoxin Inactivation Using Aqueous Extract of Ajowan (Trachyspermum ammi) Seeds

Hajare¹,

Sharma²

2005

Journal of Food Science

View full text Add to dashboard Cite

: Aqueous extract of ajowan seeds was found to contain an aflatoxin inactivation factor (IF). Thin layer chromatography analysis of the toxins after treatment with IF showed relative reduction of aflatoxin G1 > G2 > B1 > B2. Quantification of toxin using a fluorotoxin meter as well as the Enzyme Linked Immuno s orb ent Assay (ELISA) confirmed these findings. An approximate 80% reduction in total aflatoxin content over the controls was observed. This observed phenomenon of reduction in total toxin was referred to as toxin inactivation. Temperature was found to influence the rate of toxin inactivation. At 45 °C, it was found to be rapid during the initial 5 h and slowed later. The IF was found to retain considerable activity even after boiling and autoclaving, indicating partial heat stability. The activity was lost below pH 4.0. Above pH 4.0, it increased gradually, reaching the maximum at pH 10.0. IF was found to be stable to gamma irradiation. Toxin decontamination in spiked corn samples could be achieved using IF. This study emphasizes the potential of ajowan IF in aflatoxin removal from contaminated food commodities. However, the biological toxicity, if any, of the IF inactivated aflatoxins needs to be confirmed, and the work in this direction is in progress.

show abstract

“…Others authors have also observed the antioxidant capacity of onion. Sujatha and Srivinas (1995) showed that the aqueous extract of Allium cepa inhibited lipid peroxidation (LPO) in human erythrocyte membrane. Similarly, Helen et al (2000) verified a decrease in the LPO levels in liver, lung and heart of onion oil and nicotine treated rats and that this treatment increased activity of scavenging enzymes, such as catalase and superoxide dismutase (SOD) in all the tissues studied.…”

Section: Discussionmentioning

confidence: 99%

Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line

et al. 2010

View full text Add to dashboard Cite

Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the Lucena cells experienced a significant increase of necrosis. An antioxidant capacity was verified for OE discarding oxidative damage. However, OE provoked similar significant DNA damage in both cell lines. Thus, the OE capacity to overcome the MDR phenotype suggests anti-MDR action of OE.

show abstract

Modulation of lipid peroxidation by dietary components

Cited by 22 publications

References 20 publications

Effect of biologically active substances present in water extracts of white mustard and coriander on antioxidant status and lipid peroxidation of mouse C2C12 skeletal muscle cells

Effect of biologically active substances present in water extracts of white mustard and coriander on antioxidant status and lipid peroxidation of mouse C2C12 skeletal muscle cells

Aflatoxin Inactivation Using Aqueous Extract of Ajowan (Trachyspermum ammi) Seeds

Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line

Contact Info

Product

Resources

About