Cell Reports volume 4, issue 6, P1108-1115 2013 DOI: 10.1016/j.celrep.2013.08.019 View full text
Ke Zhao, Juan Du, Xue Han, John L. Goodier, Peng Li, Xiaohong Zhou, Wei Wei, Sean L. Evans, Linzhang Li, Wenyan Zhang, Ling E. Cheung, Guanjun Wang, Haig H. Kazazian, Xiao-Fang Yu et al.

Abstract: SUMMARY Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood. Here, we demonstrate that the Aicardi-Goutières syndrome gene product SAMHD1, recently revealed to be an inhibitor of HIV/simian immunodeficiency virus (SIV) infectivity and neutralized by the viral Vpx protein, is also a potent regulator of LINE-1 and LINE-1-mediated Alu/SVA retrot…

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