Modulation of intrinsic resting-state fMRI networks in women with chronic migraine

Androulakis, X Michelle; Krebs, Kaitlin; Peterlin, B. Lee; Zhang, Tianming; Maleki, Nasim; Sen, Souvik; Rorden, Chris; Herath, Priyantha

doi:10.1212/wnl.0000000000004089

Cited by 67 publications

(78 citation statements)

References 32 publications

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“…All CM w/MOH participants were age (± 5 years) and gender matched to healthy controls. Healthy controls were selected from a pool of healthy controls collected in a previous study . Controls were excluded if they had a family history of migraine or used over the counter/prescription pain medication for more than 5 days per month.…”

Section: Methodsmentioning

confidence: 99%

“…The CEN 20 consists of the bilateral anterior thalamus, bilateral dlPFC, bilateral dorsal PFC region of frontal eye fields (dPFC/FEF), bilateral vlPFC, dorsal medial PFC (dmPFC), right inferior frontal gyrus (IFG)/frontal operculum, right inferior temporal, bilateral lateral parietal, left OFI, bilateral dorsal caudate (dCaudate), and right ventromedial caudate (vmCaudate). The exact ROIs (and their MNI coordinates) can be found in our previous publication and are illustrated in Figure .…”

Section: Methodsmentioning

confidence: 99%

“…Our lab conducted a recent study that revealed decreased overall functional connectivity in default mode network, salience network (SN) and central executive network (CEN) in chronic migraine (CM) with medication overuse headache (CM w/MOH ) . Further investigation of the node to node connectivity (NTNC) within the SN showed much more extensive disruption in regions involved in the mesocorticolimbic pathways bilaterally in CM w/MOH as compared to CM without MOH .…”

Section: Introductionmentioning

confidence: 99%

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Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study

Krebs

Rorden

2018

Headache

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In this longitudinal fMRI study, we observed improved functional connectivity within both networks, primarily involving connectivity between regions of the prefrontal cortex and limbic (cortical-limbic) structures, and between different cortical (cortical-cortical) regions after a series of repetitive SPG blockades. The overall CEN strength was also improved. Our results suggest that recurrent parasympathetic inhibition via SPG is associated with improved functional connectivity in brain regions critical to pain processing in CM .

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study

Krebs

Rorden

2018

Headache

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“…Exclusion criteria were as follows: tension‐type headache for >5 day per month, a history of any other primary headache, pregnancy, breast‐feeding, contraindication for MRI, any cardiovascular or cerebrovascular disease, uncontrolled psychiatric disorder, and drug abuse. The number of patients with CM in previous RSFC studies has ranged from 7 to 29 . In our study, we aimed to recruit >30 patients each for the CM and EM groups.…”

Section: Methodsmentioning

confidence: 99%

Altered occipital pole connectivity in chronic versus episodic migraine: Whole brain region‐of‐interest analysis of resting‐state functional connectivity

Imai

2018

Neurology & Clinical Neurosc

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Background Resting‐state functional magnetic resonance imaging has demonstrated altered resting‐state functional connectivity of several regions that participate in pain processing in individuals suffering from episodic migraines. Aim To explore migraine chronification, we investigated differences in whole brain resting‐state functional connectivity between patients with chronic and episodic migraine. Methods Thirty‐one women with chronic migraine and 31 age‐matched women with episodic migraine underwent resting‐state functional magnetic resonance imaging scanning during the interictal phase. Resting‐state functional connectivity was assessed using region‐of‐interest to region‐of‐interest analysis with 91 cortical, 15 subcortical, and 26 cerebellar areas. Results Analyses revealed that patients with chronic migraine showed a higher connectivity between the anterior cingulate cortex and bilateral occipital pole and between the right occipital and right supramarginal gyrus, anterior division, bilateral planum polare, right planum temporale, and right supplementary motor cortex than patients with episodic migraine. Conclusions Our results suggest that the occipital pole plays a key role in migraine chronification.

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“…Furthermore, right‐to‐left cardiac shunts and a procoagulant state are associated with MA in a young stroke population . Increased migraine has been associated with more widespread functional and morphological abnormalities in the brain . The rate of cardiovascular diseases (CVD) in migraineurs increases with age in both men and women in a US population study .…”

Section: Introductionmentioning

confidence: 99%

Migraine Age of Onset and Association With Ischemic Stroke in Late Life: 20 Years Follow‐Up in ARIC

et al. 2019

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Background and Purpose To evaluate the association between cumulative exposure to migraine and incidence of ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study. Methods In this ongoing, prospective longitudinal community‐based cohort, participants were interviewed to ascertain migraine history at the third visit (1993–1995), followed for ischemic stroke incidence over 20 years. We performed a post hoc analysis to evaluate the association between the age of migraine onset and ischemic stroke. Results We identified 447 migraineurs with aura (MA) and 1128 migraineurs without aura (MO) among 11,592 black and white participants. There was an association between the age of MA onset ≥50 years old (average duration = 4.75 years) and ischemic stroke when compared to no headache group (multivariable adjusted HR = 2.17, 95% CI [1.39–3.39], P < .001). MA onset <50 years old (average duration = 28.17 years) was not associated with stroke (multivariable adjusted HR = 1.31, 95% CI [0.86–2.02], P = .212). These results were consistent with our logistic regression model. MO was not associated with increased stroke regardless of the age of onset. The absolute risk for stroke in migraine with aura is 37/447 (8.27%) and migraine without aura is 48/1128 (4.25%). Conclusion As compared to the no headache participants, increased stroke risk in late life was observed in participants with late onset of MA. In this cohort, longer cumulative exposure to migraine with visual aura, as would be expected with early onset of migraine, was not associated with increased risk of ischemic stroke in late life. This study underscores the importance of the age of onset of MA in assessing stroke risk in older migraineurs.

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Modulation of intrinsic resting-state fMRI networks in women with chronic migraine

Abstract: Our results demonstrated decreased overall resting-state functional connectivity of the 3 major intrinsic brain networks in women with CM, and these patterns were associated with frequency of moderate to severe headache and cutaneous allodynia.

Cited by 67 publications

References 32 publications

Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study

Resting State Functional Connectivity After Sphenopalatine Ganglion Blocks in Chronic Migraine With Medication Overuse Headache: A Pilot Longitudinal fMRI Study

Altered occipital pole connectivity in chronic versus episodic migraine: Whole brain region‐of‐interest analysis of resting‐state functional connectivity

Migraine Age of Onset and Association With Ischemic Stroke in Late Life: 20 Years Follow‐Up in ARIC

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