Modulation of input to the spinal cord; contribution of GABA released by interneurons and glial cells by polarization at the entry of sensory information
Ingela Hammar,
Elzbieta Jankowska
Abstract:Modulation of input from primary afferent fibres has long been examined at the level of the first relay neurons of these fibres. However, recent studies reveal that input to the spinal cord may also be modulated before action potentials in intraspinal collaterals of afferent fibres reach their target neurons, even at the level of the very entry of afferent fibres to the spinal grey matter. Such modulation greatly depends on the actions of GABA via extrasynaptic membrane receptors. In the reported study we hypo… Show more
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