Modulation of inflammatory and immune responses by vitamin D

Colotta, Francesco; Jansson, Birger; Bonelli, Fabrizio

doi:10.1016/j.jaut.2017.07.007

Cited by 267 publications

(248 citation statements)

References 266 publications

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“…Cytosolic VDR mediates the effects of vitamin D. The active form of the vitamin, 1,25‐dihydroxyvitamin D, exerts important immunoregulatory and anti‐inflammatory effects by binding to the VDR, which enters the cell nucleus and acts as a ligand‐activated transcription factor to activate gene expression . Vitamin D is a member of an important group of immunomodulators that regulate the growth, differentiation and function of various immune cells; affect the secretion of cytokines and antimicrobial peptides; and play an important role in regulation of innate and adaptive immunity as well as the inflammatory cascade .…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Deng

et al. 2018

Journal of Medical Virology

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Severe hand, foot, and mouth disease (HFMD) is sometimes associated with critical complications that can cause substantial child mortality. Activity of the vitamin D receptor (VDR) may influence the outcomes of enterovirus 71 (EV71) infection. This case‐control study aimed to assess the association of single‐nucleotide polymorphisms (SNPs) in the gene encoding the VDR with the severity of EV71‐associated HFMD. We selected four VDR SNPs based on linkage disequilibrium and functional prediction, and we tested them using the SNPscan multiple SNP typing method for potential association with severity of EV71‐associated HFMD. We found a significant association in the case of rs11574129 (G vs A: odds ratio (OR), 0.3439; 95% confidence intervals (CI), 0.1778‐0.6653) and rs739837 (T vs G: OR, 0.5580; 95%CI, 0.3352‐0.9291). Our results suggest that these two SNPs may influence the severity of EV71‐associated HFMD.

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Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Deng

et al. 2018

Journal of Medical Virology

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“…Therefore, accumulating evidence suggests a highly complex role of vitamin D. It is noteworthy that vitamin D regulates several adipose tissue cytokines including leptin [123]. Recent evidence on the association between vitamin D deficiency and obesity clearly indicates that the functions of this vitamin are not limited to the maintenance of bone tissue and calcium metabolism [124], [125], [126], [127], [128].…”

Section: Characteristics Of Her2 Expressionmentioning

confidence: 99%

Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment

Ray

2017

Hormone Molecular Biology and Clinical Investigation

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Abstract:Obesity is associated with the risk of several health disorders including certain cancers. Among obesity-related cancers, postmenopausal breast carcinoma is a well-studied one. Apart from an increase in certain types of lipids in obesity, excess adipose tissue releases many hormone-like cytokines/adipokines, which are usually pro-inflammatory in nature. Leptin is one of such adipokines and significantly linked with the intracellular signaling pathways of other growth factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER2). In general, HER2 is overexpressed in roughly 30% of breast carcinomas; its presence indicates aggressive tumor behavior. Conversely, HER2 has certain effects in normal conditions such as differentiation of preadipocytes, cardiovascular health and vitamin D metabolism. HER2 has no known endogenous ligand, but it may form dimers with other three members of the epidermal growth factor receptor (EGFR) family and can activate downstream signaling pathways. Furthermore, HER2 is intimately connected with several enzymes, e.g. fatty acid synthase (FASN), phosphatidylinositol 3-kinase (PI3K), AKT and mechanistic target of rapamycin (mTOR), all of which play significant regulatory roles in lipogenic pathways or lipid metabolism. In obesity-related carcinogenesis, characteristics like insulin resistance and elevated IGF-1 are commonly observed. Both IGF-1 and leptin can modulate EGFR and HER2 signaling pathways. Although clinical studies have shown mixed results, the behavior of HER2+ tumor cells including HER2 levels can be altered by several factors such as obesity, leptin and fatty acids. A precise knowledge is useful in new therapeutic approaches against HER+ tumors.

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“…Recently, mounting studies regarding vitamin D immunological function have further explored this issue. Calcitriol (1,25‐dihydroxyvitamin D 3 ), the biologically active form of vitamin D, facilitated the differentiation and function of T regulatory (Treg) cells, encouraged the apoptosis of activated B cells and dendritic cells, and restrained the generation of plasma cells and the production of autoantibodies . In addition, several intervention and epidemiological studies have elaborated that vitamin D deficiency elevated the risk of SLE .…”

Section: Introductionmentioning

confidence: 99%

Association between circulating 25‐hydroxyvitamin D and systemic lupus erythematosus: A systematic review and meta‐analysis

et al. 2019

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Aim The indicators for measuring vitamin D are various, and 25‐hydroxyvitamin D (25(OH)D) is considered as the optimal indicator of total vitamin D levels. In this study, we aim to deeply explore the 25(OH)D status in systemic lupus erythematosus (SLE) patients, and evaluate its relation to SLE risk and disease severity. Methods Literature about 25(OH)D status and its associations with SLE were searched in Pubmed, Embase and Cochrane Library databases. Standardized mean difference (SMD), odds ratio (OR) and corresponding 95% confidence interval (95% CI) were illustrated by forest plots, and correlation coefficients (r) were combined by generic inverse variance method. Heterogeneity and publication bias were quantified by I‐squared (I2) test, funnel plot and Egger's test, respectively. Sensitivity analyses were further examined by leave‐one‐out method. Results Nineteen articles were included into our meta‐analysis. The overall results showed that compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in SLE patients (pooled SMD = −1.63, 95% CI: −2.51 to −0.76). Subgroup analysis revealed that compared with the healthy controls, SLE patients of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) ≥ 10, Arab and European ethnicity, all 4 seasons, no vitamin D supplement, had significantly lower circulating 25(OH)D levels; no significant differences were observed in SLE patients of SLEDAI < 10, mixed ethnicity, spring, summer, vitamin D supplement, respectively; no matter the changes of age, disease duration, and the therapy of corticosteroid or immunosuppressive or neither, circulating 25(OH)D levels were significantly reduced in SLE patients. The deficiency, insufficiency and sufficiency of vitamin D could significantly elevate, slightly decrease (not significantly), significantly decrease SLE risk, respectively (pooled OR = 4.37, 95% CI: 1.49 to 12.84; pooled OR = 0.52, 95% CI: 0.22 to 1.26; pooled OR = 0.31, 95% CI: 0.15 to 0.63). Circulating 25(OH)D levels were inversely associated with SLEDAI (pooled correlation coefficient = −0.50, 95% CI: −0.8278 to −0.1689). Conclusions Compared with healthy controls, 25(OH)D levels are significantly lower in SLE patients, which is influenced by disease activity, ethnicity, seasons and vitamin D supplement; no matter the change of age, diseases duration and therapy of corticosteroid or immunosuppressive or neither, 25(OH)D levels are significantly decreased in SLE patients; the deficiency, insufficiency and sufficiency of vitamin D could significantly elevate, slightly decrease, and significantly decrease SLE risk, respectively; and 25(OH)D levels inversely correlate with SLEDAI.

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Modulation of inflammatory and immune responses by vitamin D

Cited by 267 publications

References 266 publications

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Association of polymorphisms in the vitamin D receptor gene with severity of hand, foot, and mouth disease caused by enterovirus 71

Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment

Association between circulating 25‐hydroxyvitamin D and systemic lupus erythematosus: A systematic review and meta‐analysis

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