Modulation of Inflammation in Wounds of Diabetic Patients Treated with Porcine Urinary Bladder Matrix

Paige, John T.; Kremer, Michael; Landry, Jace P.; Hatfield, Samuel A.; Wathieu, Donald; Brug, Aaron; Lightell, Daniel; Spiller, Kara L.; Woods, T. Cooper

doi:10.2217/rme-2019-0009

Cited by 22 publications

(33 citation statements)

References 34 publications

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“…Although the full contributory role of ADMs in DFUs has not yet been elucidated, the mechanistic effects of specific proprietary ADMs has been witnessed. In one study, application of a xenogenic ADM was able to return the M1:M2 macrophage polarization ratio normally seen in DFUs to that of normally-healing wounds [ 97 ]. Furthermore, ADMs have also been witnessed to induce increased levels of microvascular blood flow within DFUs [ 98 ].…”

Section: Acellular Dermal Matricesmentioning

confidence: 99%

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Holl

Kowaléwski

Zimek

et al. 2021

Cells

144

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With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic, hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The growing understanding of healing and regenerative mechanisms has elucidated critical regulators of this process, including key cellular and humoral components. Despite this, the management and successful treatment of diabetic wounds represents a significant therapeutic challenge. To this end, the development of novel therapies and biological dressings has gained increased interest. Here we review key differences between normal and chronic non-healing diabetic wounds, and elaborate on recent advances in wound healing treatments with a particular focus on biological dressings and their effect on key wound healing pathways.

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Section: Acellular Dermal Matricesmentioning

confidence: 99%

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Holl

Kowaléwski

Zimek

et al. 2021

Cells

144

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“…DM2 has been shown to modulate the macrophage phenotype and increase the ratio of pro-and anti-inflammatory macrophages [17] . However, glycation has been shown to modulate the macrophage phenotype against the anti-inflammatory state in the long term [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory cells in the ascending aortic aneurysm in patients with type 2 diabetes versus patients with hypertension

Milutinović

Zorc-Pleskovič

2021

Bosn J of Basic Med Sci

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Aortic aneurysms occur relatively frequently in the ascending thoracic aorta, but are rarely seen in patients with type 2 diabetes. Our aim was to evaluate inflammatory cell infiltration in the ascending aortic aneurysm wall in patients with diabetes without arterial hypertension (DM2 group, N=6) versus hypertensive non-diabetic patients (AH group, N=34). For histologic analysis, the sections were stained with hematoxylin-eosin and Movat pentachrome. The immunohistochemical staining was used to analyze the infiltration of pro-inflammatory (CD68) and anti-inflammatory macrophages (CD163), T helper (CD4) and T killer cells (CD8), and B (CD79a) and plasma cells (CD138) in all three layers of aneurysms of both groups. The statistical significance of the differences between groups was evaluated by ANOVA and the Welch test. In comparison to the AH group, the DM2 group developed less severe infiltration of pro-inflammatory macrophages (P=0.004) and B cells (P=0.025) in the tunica intima, and tunica media (P=0.049, P=0.007, respectively), and fewer plasma cells in the tunica media (P=0.024) and tunica adventitia (P=0.017). We found no significant differences in the number of T helper, T killer cells, and anti-inflammatory macrophages and in the amount of collagen and elastic fibers, ground substance, and smooth muscle cells in all three layers of the vessel wall. Except in tunica adventitia of DM2 group, there were more collagen fibers overall (P=0.025). Thus, we conclude that the histological structure of the aneurysm in diabetics without hypertension is almost the same as in hypertensive patients without diabetes. Diabetics had significantly less inflammatory infiltration in all three layers of the vessel wall, and more collagen fibers in tunica adventitia.

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“…AlloDerm ® showed that the macrophages were mostly M1 at 7, 14, 21, and 42 days post implantation, while Integra ® showed a mixed M1/M2 population of macrophages at all time-points: The trend for the M1:M2 ratio was skewed towards M2 on day 7, towards M1 on days 14 to 21, and again towards M2 on day 42 for Integra ® [156]. A recent study showed that the implant of a porcine urinary bladder matrix (UBM) is associated with the modulation of wound inflammation in diabetic patients, measured as mRNA associated with M1 and M2 macrophages [157]. Recently, Montanaro et al show investigate how the dermal substitute Nevelia ® , which is a dermal substitute consisting of a three-dimensional porous matrix of type 1; purified, stabilized, bovine-origin collagen; and a layer of reinforced silicone may influence the inflammatory infiltrate and macrophages polarization [158].…”

Section: Dermal Substitutesmentioning

confidence: 98%

The Immune-Centric Revolution in the Diabetic Foot: Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration—A Narrative Review

Rehak

Giurato

Meloni

et al. 2022

JCM

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Monocytes and lymphocytes play a key role in physiologic wound healing and might be involved in the impaired mechanisms observed in diabetes. Skin wound macrophages are represented by tissue resident macrophages and infiltrating peripheral blood recruited monocytes which play a leading role during the inflammatory phase of wound repair. The impaired transition of diabetic wound macrophages from pro-inflammatory M1 phenotypes to anti-inflammatory pro-regenerative M2 phenotypes might represent a key issue for impaired diabetic wound healing. This review will focus on the role of immune system cells in normal skin and diabetic wound repair. Furthermore, it will give an insight into therapy able to immuno-modulate wound healing processes toward to a regenerative anti-inflammatory fashion. Different approaches, such as cell therapy, exosome, and dermal substitute able to promote the M1 to M2 switch and able to positively influence healing processes in chronic wounds will be discussed.

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Modulation of Inflammation in Wounds of Diabetic Patients Treated with Porcine Urinary Bladder Matrix

Cited by 22 publications

References 34 publications

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Chronic Diabetic Wounds and Their Treatment with Skin Substitutes

Inflammatory cells in the ascending aortic aneurysm in patients with type 2 diabetes versus patients with hypertension

The Immune-Centric Revolution in the Diabetic Foot: Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration—A Narrative Review

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