Modulation of <i>Salmonella</i> Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism

Chen, Jianxiang; Qiao, Yiting; Tang, Bo; Chen, Guo; Liu, Xiufeng; Yang, Bo; Wei, Jing; Zhang, Xiangyu; Cheng, Xiawei; Du, Pan; Jiang, Wenhui; Hu, Qingang; Hua, Zichun

doi:10.7150/thno.18816

Cited by 58 publications

(51 citation statements)

References 43 publications

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“…F., which possesses diverse effects including anti-inflammatory, anti-oxidative, and anti-cancer activities [60,406,407]. For cancer therapy, it has been used to treat breast, lung, bladder, liver, colorectal, pancreatic, ovarian, stomach, prostate, cervical, and oral cancers, melanoma, myeloma, leukemia, neuroblastoma, osteosarcoma, lymphoma, renal, nasopharyngeal, and endometrial carcinoma, through apoptosis, cell cycle arrest, inhibition of cell proliferation, metastasis and angiogenesis [406,[408][409][410][411][412][413][414][415][416][417][418][419][420][421][422][423][424][425][426].…”

Section: Triptolidementioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Triptolidementioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…When infected with Salmonella, YAP coactivator activity is inhibited by phosphorylation and its interaction with Hck, a protein known to bind YAP and sequester it in the cytosol, preventing its nuclear translocation, resulting in the downregulation of a proapoptotic molecule, namely NLR family CARD domain containing protein 4 (NLRC4), which impairs IL1b secretion and prevents B-cell death (79). Salmonella is a good candidate for the specific delivery of therapeutic agents during tumor therapy (80,81). These results indicate that YAP/TAZ is undeniably important for the functionality and development of B cells and further studies are required to fully elucidate these functions.…”

Section: Yap/taz In Regulating B Cellsmentioning

confidence: 99%

The Emerging Role of YAP/TAZ in Tumor Immunity

Pan

Tian²,

Cao

et al. 2019

Molecular Cancer Research

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Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway that has emerged as a critical determinant of malignancy in many human tumors. YAP/TAZ expression regulates the cross-talk between immune cells and tumor cells in the tumor microenvironment through its influence on T cells, myeloid-derived suppressor cells, and macrophages. However, the mechanisms underlying these effects are poorly understood. An improved understanding of the role of YAP/TAZ in tumor immunity is essential for exploring innovative tumor treatments and making further breakthroughs in antitumor immunotherapy. This review primarily focuses on the role of YAP/TAZ in immune cells, their interactions with tumor cells, and how this impacts on tumorigenesis, progression, and therapy resistance.

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“…Triptolide, which was the first diterpenoid triepoxide lactone isolated from Tripterygium wilfordii Hook F, has been recognized as a principal component responsible for the biological activities of the plant (5). Triptolide has been demonstrated to possess a wide range of biological activities, such as anticancer, immunosuppressive, contraceptive, anti-angiogenic, and anti-inflammatory activities (6–10). In 2007, in addition to celastrol, artemisinin, capsaicin, and curcumin, triptolide was deemed to be a “poster child” due to its power and potential of transforming traditional medicine into modern medicine (11).…”

Section: Introductionmentioning

confidence: 99%

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways

et al. 2019

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Apoptosis and autophagy are the two prominent forms of developmental cell death, and researches have shown that crosstalk exists between these two processes. A prior study demonstrated that triptolide inhibited the proliferation of malignant glioma cells. However, whether apoptosis and autophagy participate in the inhibitory effect of triptolide in glioma cells has not been clarified. In the present study, we demonstrated that triptolide potently inhibited the growth of glioma cells by inducing cell cycle arrest at the G2/M phase. Additionally, the treatment with triptolide induced apoptosis and autophagy in various glioma cell lines. Triptolide-induced autophagy may have tumor-supporting effects. Autophagy and apoptosis could cross-inhibit each other in glioma cells treated with triptolide. Moreover, we found that triptolide induced ROS production and JNK activation and inhibited the activity of Akt and mTOR. Finally, we demonstrated that triptolide suppressed tumor growth in an orthotopic xenograft glioma model. Collectively, these data indicated that triptolide induced G2/M phase arrest, apoptosis, and autophagy via activating the ROS/JNK and blocking the Akt/mTOR signaling pathways in glioma cells. Triptolide may be a potential anti-tumor drug targeting gliomas.

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Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism

Cited by 58 publications

References 43 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

The Emerging Role of YAP/TAZ in Tumor Immunity

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways

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