Modulation of human lymphocyte proliferation by FLFQPQRFamide, a FMRFamide-like peptide with anti-opiate properties

Lecron, Jean‐Claude; Minault, Martine; Allard, Michèle; Laforest, P. Goube de; Gombert, J.; Simonnet, Guy

doi:10.1016/0165-5728(92)90084-x

Cited by 25 publications

(11 citation statements)

References 21 publications

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“…Precedent exists for such a relationship; genes have been described which are shared between S. mansoni and Deuterostomia but absent from Ecdysozoa (Venancio et al, 2007), these are thought to have been “co-opted” by schistosomes, perhaps by horizontal gene transfer, to perform a role in host-parasite interactions. It is interesting to consider such a role for NPP-13 in schistosomes since NPFF has been shown to stimulate or inhibit T-cell proliferation at low or high concentrations, respectively (Lecron et al, 1992; Minault et al, 1995). The ability to modulate the proliferation of T-cells by the release of Sm-NPP-13 would have obvious survival benefits for an intravascular parasite.…”

Section: Discussionmentioning

confidence: 99%

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

McVeigh

Mair

Atkinson³

et al. 2009

International Journal for Parasitology

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Available evidence shows that short amidated neuropeptides are widespread and have important functions within the nervous systems of all flatworms (phylum Platyhelminthes) examined, and could therefore represent a starting point for new lead drug compounds with which to combat parasitic helminth infections. However, only a handful of these peptides have been characterised, the rigorous exploration of the flatworm peptide signalling repertoire having been hindered by the dearth of flatworm genomic data. Through searches of both expressed sequence tags and genomic resources using the basic local alignment search tool (BLAST), we describe 96 neuropeptides on 60 precursors from 10 flatworm species. Most of these (51 predicted peptides on 14 precursors) are novel and are apparently restricted to flatworms; the remainder comprise nine recognised peptide families including FMRFamide-like (FLPs), neuropeptide F (NPF)-like, myomodulin-like, buccalin-like and neuropeptide FF (NPFF)-like peptides; notably, the latter have only previously been reported in vertebrates. Selected peptides were localised immunocytochemically to the Schistosoma mansoni nervous system. We also describe several novel flatworm NPFs with structural features characteristic of the vertebrate neuropeptide Y (NPY) superfamily, previously unreported characteristics which support the common ancestry of flatworm NPFs with the NPY-superfamily. Our dataset provides a springboard for investigation of the functional biology and therapeutic potential of neuropeptides in flatworms, simultaneously launching flatworm neurobiology into the post-genomic era.

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Section: Discussionmentioning

confidence: 99%

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

McVeigh

Mair

Atkinson³

et al. 2009

International Journal for Parasitology

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“…However, low levels of hNPFF2 receptor transcripts have been detected in the periphery (Bonini et al . 2000) and NPFF binding sites have been found on human T lymphocytes (Lecron et al . 1992).…”

Section: Discussionmentioning

confidence: 99%

Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK‐N‐MC neuroblastoma cell line

Änkö

Panula

2005

Journal of Neurochemistry

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Neuropeptide FF has many functions both in the CNS and periphery. Two G protein-coupled receptors (NPFF1 and NPFF2 receptors) have been identified for neuropeptide FF. The expression analysis of the peptide and receptors, together with pharmacological and physiological data, imply that NPFF2 receptor would be the primary receptor for neuropeptide FF. Here, we report for the first time a cell line endogenously expressing hNPFF2 receptor. These SK-N-MC neuroblastoma cells also express neuropeptide FF. We used the cells to investigate the hNPFF2 receptor function. The pertussis toxin-sensitive inhibition of adenylate cyclase activity upon receptor activation indicated coupling to G i/o proteins. Upon agonist exposure, the receptors were internalized and the mitogen-activated protein kinase cascade was activated.Upon neuropeptide FF treatment, the actin cytoskeleton was reorganized in the cells. The expression of hNPFF2 receptor mRNA was up-regulated by neuropeptide FF. Concomitant with the receptor mRNA, the receptor protein expression was increased. The homologous regulation of hNPFF2 receptor correlates with our previous results in vivo showing that during inflammation, the up-regulation of neuropeptide FF mRNA precedes that of NPFF2 receptor. The regulation of hNPFF2 receptor by NPFF could also be important in the periphery where neuropeptide FF has been suggested to function as a hormone.

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“…It has been shown that NPFF neuropeptides reduce production of nitric oxide in macrophages and exhibit antiinflammatory activity in a mouse model (Sun et al, 2013). Furthermore, T lymphocytes have binding sites for NPFF, and data indicate that NPFF can modulate T lymphocyte proliferation to fine tune an immune response (Lecron et al, 1992;Minault et al, 1995).…”

Section: Candidate Genes Within the Targeted Regionmentioning

confidence: 98%

Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle

Sahana

Guldbrandtsen

Thomsen

et al. 2014

Journal of Dairy Science

100

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Mastitis is a mammary disease that frequently affects dairy cattle. Despite considerable research on the development of effective prevention and treatment strategies, mastitis continues to be a significant issue in bovine veterinary medicine. To identify major genes that affect mastitis in dairy cattle, 6 chromosomal regions on Bos taurus autosome (BTA) 6, 13, 16, 19, and 20 were selected from a genome scan for 9 mastitis phenotypes using imputed high-density single nucleotide polymorphism arrays. Association analyses using sequence-level variants for the 6 targeted regions were carried out to map causal variants using whole-genome sequence data from 3 breeds. The quantitative trait loci (QTL) discovery population comprised 4,992 progeny-tested Holstein bulls, and QTL were confirmed in 4,442 Nordic Red and 1,126 Jersey cattle. The targeted regions were imputed to the sequence level. The highest association signal for clinical mastitis was observed on BTA 6 at 88.97 Mb in Holstein cattle and was confirmed in Nordic Red cattle. The peak association region on BTA 6 contained 2 genes: vitamin D-binding protein precursor (GC) and neuropeptide FF receptor 2 (NPFFR2), which, based on known biological functions, are good candidates for affecting mastitis. However, strong linkage disequilibrium in this region prevented conclusive determination of the causal gene. A different QTL on BTA 6 located at 88.32 Mb in Holstein cattle affected mastitis. In addition, QTL on BTA 13 and 19 were confirmed to segregate in Nordic Red cattle and QTL on BTA 16 and 20 were confirmed in Jersey cattle. Although several candidate genes were identified in these targeted regions, it was not possible to identify a gene or polymorphism as the causal factor for any of these regions.

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Modulation of human lymphocyte proliferation by FLFQPQRFamide, a FMRFamide-like peptide with anti-opiate properties

Cited by 25 publications

References 21 publications

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

Discovery of multiple neuropeptide families in the phylum Platyhelminthes

Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK‐N‐MC neuroblastoma cell line

Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle

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