Modulation of hepatic gene expression and DNA methylation in furan treated Sprague–Dawley rats

Chen, Tao; Hickling, Kevin; Hamberger, Carolin; Mally, Angela; Chipman, Kevin

doi:10.1016/j.toxlet.2009.06.725

Cited by 2 publications

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“…for up to 6 wk was found to induce substantial cell proliferation (18-to 51-fold increase over combined controls) without changes in liver associated plasma enzymes, suggesting that BrdU labeling may be a more sensitive indicator of response. Importantly, however, we found evidence for subcapsular hepatocyte proliferation and associated changes in the expression of cell-cyclerelated genes [26] even in the low-dose range for which no tumor data are yet available. Considering the close link between cell proliferation and tumorigenesis, these findings suggest that chronic administration of furan at doses as low as 0.1 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 64%

Functional and proliferative effects of repeated low‐dose oral administration of furan in rat liver

Mally

Graff

Schmal

et al. 2010

Molecular Nutrition Food Res

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Although statistically significant effects were only seen at the 2 mg/kg b.w. dose during the course of our study, a ∼two and ∼threefold increase in 5-bromo-2'-deoxyuridine labeling index was observed at 0.1 and 0.5 mg/kg b.w., respectively, suggesting that chronic exposure to doses even below 2 mg/kg b.w. may cause proliferative changes in rat liver and highlighting the need to assess furan carcinogenicity at lower doses.

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Section: Discussionmentioning

confidence: 64%

Functional and proliferative effects of repeated low‐dose oral administration of furan in rat liver

Mally

Graff

Schmal

et al. 2010

Molecular Nutrition Food Res

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Toxicity and carcinogenicity of furan in human diet

2010

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Furan is formed during commercial or domestic thermal treatment of food. The initial surveys of furan concentrations in heat-treated foods, published by European and US authorities, revealed the presence of relatively high furan levels in coffee, sauces, and soups. Importantly, furan is consistently found in commercial ready-to-eat baby foods. Furan induces hepatocellular tumors in rats and mice and bile duct tumors in rats with a high incidence. Epidemiological studies are not available. It is assumed that cis-2-butene-1,4-dial, the reactive metabolite of furan, is the causative agent leading to toxicity and carcinogenicity. Based on this data, furan is classified as a possible human carcinogen. The initial exposure estimates revealed a relatively small margin (~2,000) between human exposure and those furan doses, which induce liver tumors in experimental animals. As this may give rise for concern, in this review, the currently available toxicological and mechanistic data of furan are summarized and discussed with regard to its applicability in assessing the risk of furan in human diet.

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Modulation of hepatic gene expression and DNA methylation in furan treated Sprague–Dawley rats

Cited by 2 publications

References 0 publications

Functional and proliferative effects of repeated low‐dose oral administration of furan in rat liver

Functional and proliferative effects of repeated low‐dose oral administration of furan in rat liver

Toxicity and carcinogenicity of furan in human diet

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