Modulation of Gut Microbiota Metabolism in Obesity-Related Type 2 Diabetes Reduces Osteomyelitis Severity

Bui, Tina I; Gill, Ann Lindley; Mooney, Robert A.; Gill, Steven R.

doi:10.1128/spectrum.00170-22

Cited by 20 publications

(15 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enteral feeding also increases the risks of reflux and changes in the pH or urea content ( 43 ). Several reports ( 33 , 34 ) have shown that the intestinal microbiota composition was one of the factors responsible for the enhancement of intestinal permeability. To our knowledge, this is the first report to clarify that enteral feeding has additional effects on translocation from rectal carriage to clinical infection associated with CRE.…”

Section: Discussionmentioning

confidence: 99%

“…Colonization of the intestine by nonhost niche microorganisms can lead to a permeable gut through various mechanisms ( 30 – 38 ), by either being directly responsible for the features of inflammation ( 30 – 32 ) or favoring microbe-microbe and microbe-host interactions such as regulating the diversity and community composition of the cecal microbiome ( 33 , 34 ), manipulating bacterial metabolites ( 35 , 36 ), participating the innate and the adaptive immune responses ( 37 ), and penetrating host barriers ( 38 ), allowing colonizing microorganisms to invade the intestinal tissue and leading to subsequent translocated infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection

Yuan

Guo

et al. 2022

Microbiol Spectr

View full text Add to dashboard Cite

Carbapenem-resistant Enterobacteriaceae have emerged as a major threat to modern medicine, and the spread of carbapenem-resistant Enterobacteriaceae is a clinical and public health problem. Gastrointestinal colonization by potential pathogens is always a prerequisite for the development of translocated infections, and there is a growing need to assess clinical risk factors and microbiological and intestinal characteristics to prevent the development of clinical infection by carbapenem-resistant Enterobacteriaceae .

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection

Yuan

Guo

et al. 2022

Microbiol Spectr

View full text Add to dashboard Cite

show abstract

“…With increasing antibiotic resistance and limited discoveries of novel antibiotics, it is imperative that need to explore other avenues for therapeutics [67]. Han et al reported that regulating the relationship between phages and bacteria can maintain the health of the body and even reverse diseases [68].…”

Section: Medicine Advancesmentioning

confidence: 99%

Global prevalence of Staphylococcus aureus in food products and its relationship with the occurrence and development of diabetes mellitus

Liang

Zeng²,

et al. 2023

Medicine Advances

View full text Add to dashboard Cite

The worldwide distribution of Staphylococcus aureus across food types is an important food safety concern. This study aimed to estimate the prevalence of S. aureus in food products and its relationship with the occurrence and development of diabetes mellitus. A total of 55 articles were included. The pooled prevalence of S. aureus was 30.2%. The highest prevalence of S. aureus was observed in cereals, followed by meat and bean products, and the lowest in confectionery, egg products, and vegetables. The prevalence in dairy and seafood products was similar. Combinations of culture and molecular methods have been used for S. aureus detection. Furthermore, the prevalence of S. aureus in developed countries (Europe and North America) was higher than that in developing countries (Asia and Africa). In addition, the prevalence was higher in the provinces of Xinjiang and Shaanxi than that in Sichuan and Shandong in China, which may be due to the difference in climate and dietary habits. The results revealed that food type, bacterial detection methods, and location can influence the prevalence of S. aureus contamination. Resistance rates to preferred antibiotics against S. aureus were the highest for cephradine, polymyxin B, and penicillin at 82.9%, 82.0%, and 81.3%, respectively. In addition, 17 studies were system reviewed that the S. aureus infections are closely associated with the development of diabetes, and the treatment of probiotic, prebiotic, FMT, and bacteriophage can prevent and control S. aureus infections. This review emphasizes the high prevalence of S. aureus contamination in food, suggesting a potential diabetic infection risk and importance of observing principles of food safety and hygiene to reduce S. aureus.

show abstract

“…Additionally, the gut microbiota is closely associated with serum metabolites, and it may bridge the distance between the gut and distant organs 27 . Modulating the gut microbiota can alter serum metabolites, a mechanism that can alter the treatment of several diseases 28–30 . Likewise, it may be possible to alleviate periodontal bone destruction in patients with DMP by ingestion of probiotics, with regulation of the gut microbiota dysbiosis and alterations in serum metabolites as potential mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus

Zhang,

Lu,

Zhang

et al. 2023

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The gut microbiota is a bridge linking periodontitis and systemic diseases, such as diabetes mellitus (DM). The probiotic Clostridium butyricum MIYAIRI 588 (CBM588) is reportedly an effective therapeutic approach for gut dysbiosis. Here, in a mouse model, we explored the therapeutic effect of CBM588 on periodontal bone destruction in DM and DM‐associated periodontitis (DMP), as well as the underlying mechanism. Micro‐computed tomography revealed that DM and DMP both aggravated periodontal bone destruction, which was alleviated by intragastric supplementation with CBM588. Moreover, 16S rRNA sequencing and untargeted metabolite analysis indicated that CBM588 ameliorated DMP‐triggered dysbiosis and led to reduced oxidative stress associated with elevated 4‐hydroxybenzenemethanol (4‐HBA) in serum. Furthermore, in vitro and in vivo experiments found that the metabolite 4‐HBA promoted nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling activation and modulated the polarization of macrophages, thus ameliorating inflammatory bone destruction in DMP. Our study demonstrates the protective effects of CBM588 in DM‐induced mice, with and without ligature‐induced periodontitis. The mechanism involves regulation of the gut microbiota and restoration of the integrity of the gut barrier to alleviate oxidative damage by elevating serum 4‐HBA. This study suggests the possibility of CBM588 as a therapeutic adjuvant for periodontal treatment in diabetes patients.

show abstract

Modulation of Gut Microbiota Metabolism in Obesity-Related Type 2 Diabetes Reduces Osteomyelitis Severity

Cited by 20 publications

References 91 publications

Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection

Clinical Risk Factors and Microbiological and Intestinal Characteristics of Carbapenemase-Producing Enterobacteriaceae Colonization and Subsequent Infection

Global prevalence of Staphylococcus aureus in food products and its relationship with the occurrence and development of diabetes mellitus

Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus

Contact Info

Product

Resources

About