Modulation of gut microbiota downregulates the development of food allergy in infancy

Tsabouri, Sophia; Priftis, Kostas Ν.; Chaliasos, Nikolaos; Siamopoulou, Antigoni

doi:10.1016/j.aller.2013.03.010

Cited by 29 publications

(37 citation statements)

References 80 publications

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“…The main factors driving community establishment in these distinct compartments are depicted with black bars. The gut drawing is adapted from Tsabouri et al (2014) with permission from the publisher.…”

Section: Physiological Functions Of the Vertebrate Gut And Plant Rootsmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

615

470

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Plants and animals each have evolved specialized organs dedicated to nutrient acquisition, and these harbor specific bacterial communities that extend the host's metabolic repertoire. Similar forces driving microbial community establishment in the gut and plant roots include diet/soil-type, host genotype, and immune system as well as microbe-microbe interactions. Here we show that there is no overlap of abundant bacterial taxa between the microbiotas of the mammalian gut and plant roots, whereas taxa overlap does exist between fish gut and plant root communities. A comparison of root and gut microbiota composition in multiple host species belonging to the same evolutionary lineage reveals host phylogenetic signals in both eukaryotic kingdoms. The reasons underlying striking differences in microbiota composition in independently evolved, yet functionally related, organs in plants and animals remain unclear but might include differences in start inoculum and niche-specific factors such as oxygen levels, temperature, pH, and organic carbon availability.

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Section: Physiological Functions Of the Vertebrate Gut And Plant Rootsmentioning

confidence: 99%

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Hacquard¹,

Garrido‐Oter²,

González³

et al. 2015

Cell Host & Microbe

615

470

View full text Add to dashboard Cite

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“…8 Therefore, we investigated whether there was any relation to the presence of infection in the mother and her use of antibiotics during the pregnancy and the development of CMPA. In our study, in the CMPA group, there was a greater frequency in antibiotic use and it was statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Perinatal factors associated with the development of cow's milk protein allergy

Monjaráz

Mayans

Bustamante

et al. 2015

Revista de Gastroenterología de México (English Edition)

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The prevalence of cow's milk protein allergy (CMPA) has increased in recent years, and is associated with antimicrobial use during the perinatal period, prematurity, the type of childbirth, and the decrease in breastfeeding. The aim of this study was to analyze whether there is any association between these factors and the development of CMPA. Material and methods: A retrospective, comparative, cross-sectional, observational study was conducted by reviewing the case records of 101 children diagnosed with CMPA and seen at the Department of Gastroenterology and Nutrition of the Instituto Nacional de Pediatría within the time frame of January 2012 and August 2013. The following variables were included: age, sex, weeks of gestation, history of maternal infection and antimicrobial use during the pregnancy, type of delivery, and feeding with human milk, and its duration. Likewise, the case records of 90 children were reviewed as a control group on not having CMPA or any other allergy. The chi-square test was used for proportions, and the Mann-Whitney U test was used for comparing means in the statistical analysis. Results: The factors associated with CMPA were the use of antimicrobials during gestation and breastfeeding duration in months. Both factors were statistically significant (P < .001). No association was found between CMPA and gestational age or type of delivery. Conclusions:The statistically significant associated factors were breastfeeding duration and the use of antimicrobials during the gestational stage. These results underline the necessity for prospective studies.Alergia a las proteínas de la leche de vaca; Prematuridad; Lactancia materna; Césarea; Antibióticos Factores perinatales asociados al desarrollo de alergia a las proteínas de la leche de vaca Resumen La alergia a las proteínas de la leche de vaca se ha incrementado en los últimos años, asociado al uso de antimicrobianos en el periodo perinatal, prematuridad, el tipo de nacimiento y la disminución de la lactancia materna. El objetivo de este estudio fue analizar si existe alguna asociación entre estos factores y el desarrollo de alergia a las proteínas de la leche de vaca (APLV). Material y métodos: Estudio comparativo, retrospectivo, transversal, observacional. Se revisaron los expedientes de 101 niños con diagnóstico de APLV que asistieron al Departamento de Gastroenterología y Nutrición del INP de enero de 2012 a agosto de 2013. Se incluyeron las siguientes variables: edad, sexo, semanas de gestación, antecedente de infecciones y uso de antimicrobianos en la madre durante el embarazo, tipo de parto, alimentación con leche materna y duración de la misma. Así mismo se revisaron los expedientes de 90 niños como grupo control sin APLV ni otro tipo de alergias. Para el análisis estadístico se utilizo prueba de Chi cuadrado para proporciones o U-Mann-Whitney en el caso de comparación de medias. Resultados: Se encontró que los factores asociados a APLV fueron el uso de antimicrobianos en la etapa gestacional y la duración en meses de la lactancia ma...

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“…The composition of the microbiota may also contribute to the development of food sensitization [56,57,58,59]. Among all of the microbiota, Bifidobacterium , Bacteroides , and Staphylococcus have a protective impact towards milk allergy in mice [57,58].…”

Section: Environmental Factors Affect Dna Methylation In Food Allergymentioning

confidence: 99%

The Implications of DNA Methylation on Food Allergy

Lee

Song

O’Sullivan

et al. 2017

Int Arch Allergy Immunol

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Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the pathogenesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.

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Modulation of gut microbiota downregulates the development of food allergy in infancy

Cited by 29 publications

References 80 publications

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Microbiota and Host Nutrition across Plant and Animal Kingdoms

Perinatal factors associated with the development of cow's milk protein allergy

The Implications of DNA Methylation on Food Allergy

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