Modulation of guinea-pig lung adenylate cyclase by ovalbumin sensitization

Effects of airway inflammation on cough response in the guinea pig

“…On the other hand, although there were no significant changes in the total cell number and the eosinophils in sensitized and normal animals, we could observe a tendency toward elevation of these numbers in sensitized animals. Several studies have reported that OVA sensitization can selectively alter the coupling of ␤-adrenergic and vasoactive intestinal peptide receptors to adenylate cyclase in the lung membrane (15) and alter the intestinal mucosa to produce an immediate secretory response (7). Therefore, we speculate that immunosensitization may facilitate the release of tachykinins from C-fiber endings by single stimulation of capsaicin.…”