Modulation of gastrointestinal motility beyond metoclopramide and domperidone

Madisch, Ahmed; Vinson, Bettina R.; Abdel-Aziz, H; Kelber, O; Nieber, K; Kraft, Karin; Storr, M.

doi:10.1007/s10354-017-0557-3

Cited by 22 publications

(11 citation statements)

References 31 publications

(42 reference statements)

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“…Taking diabetic gastroparesis as an example, as many as 25%–55% of patients with type 1 diabetes have gastroparesis, with a slightly higher incidence rate in patients with type 2 diabetes, causing great suffering and poor quality of life in patients[ 11 ]. GI motility disorder is becoming a serious public health problem and a significant burden to society; however, current treatment options for gut dysmotility are limited because of serious side effects[ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Neuromechanism of acupuncture regulating gastrointestinal motility

Yu¹

2020

WJG

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Acupuncture has been used in China for thousands of years and has become more widely accepted by doctors and patients around the world. A large number of clinical studies and animal experiments have confirmed that acupuncture has a benign adjustment effect on gastrointestinal (GI) movement; however, the mechanism of this effect is unclear, especially in terms of neural mechanisms, and there are still many areas that require further exploration. This article reviews the recent data on the neural mechanism of acupuncture on GI movements. We summarize the neural mechanism of acupuncture on GI movement from four aspects: acupuncture signal transmission, the sympathetic and parasympathetic nervous system, the enteric nervous system, and the central nervous system.

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Section: Introductionmentioning

confidence: 99%

Neuromechanism of acupuncture regulating gastrointestinal motility

Yu¹

2020

WJG

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“…Следует помнить, что некоторые группы препаратов могут влиять на результаты тестирования на H. pylori, в связи с этим должны быть заблаговременно отменены, в частности антациды, препараты висмута трикалия дицитрата, ИПП. При принятии решения о начале антихеликобактерной терапии у пациентов с симптомами диспепсии всегда необходимо учитывать потенциальные побочные эффекты антибиотикотерапии, а также то, что после эрадикации H. pylori только у 10% пациентов развивается долгосрочная бессимптомная ремиссия, в то время как у остальных пациентов симптомы диспепсии довольно быстро возвращаются или сохраняются даже после того, как было достигнуто полное уничтожение H. pylori в слизистой оболочке желудка [20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Reviewunclassified

Rational treatment of patients with functional dyspepsia

Казаков

Сергеевич²,

Zyryanov

et al. 2021

Terapevticheskii arkhiv

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Functional dyspepsia is one of the most common functional disorders of the gastrointestinal tract, which resulted from impaired motor skills, visceral hypersensitivity, increased mucosal permeability, disorders of the autonomic nervous system, etc. There is no specific therapy for this disease, which often leads to the irrational use of various groups of drugs. Drug therapy is recommended only during periods of symptoms. The main options of pharmacotherapy include the use of proton pump inhibitors, phytotherapeutic drugs, eradication therapy of Helicobacter pylori. Against the background of possible motor disorders, prokinetics are also one of the possible treatment options, but cisapride has long been withdrawn from sale due to cardiotoxicity, the use of domperidone and metoclopramide is limited due to side effects, especially with long-term therapy, so currently the only prokinetic that can be used in everyday clinical practice is itopride. In refractory cases, tricyclic antidepressants and psychotherapeutic approaches are another effective treatment option.

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“…Phytotherapeutics have been used in medicine for decades, and numerous placebo-controlled trials have shown a significantly positive effect compared to placebo in the treatment of FD [10,11]. Combination preparations are often used to treat FD.…”

Section: Introductionmentioning

confidence: 99%

Menthacarin for long-term treatment of functional dyspepsia – Results from a clinical trial follow-up

Storr¹,

Stracke

2022

Z Gastroenterol

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Background Menthacarin was shown to be effective and safe in clinical trials in patients with functional dyspepsia (FD). Long-term treatment results have not been reported yet. Methods An open-label, 11-month follow-up (FU) was offered to FD patients who had undergone treatment with Menthacarin (1 gastro-resistant capsule b.i.d. vs. placebo (PL)) in a 4-week, double-blind, clinical trial. During FU, all patients (former verum and PL) were treated with 1 gastro-resistant capsule Menthacarin b.i.d. Main outcomes were the changes in pain intensity and severity of sensation of pressure, heaviness, and fullness from original baseline and global improvement. Results 70 patients were included in the analyses (former Menthacarin group: 36, former PL group: 34). At the end of the PL-controlled study phase, all 3 main efficacy variables were statistically significantly improved in the Menthacarin group compared to PL. In the FU phase, former PL patients started to improve under Menthacarin treatment towards the outcomes seen in the former Menthacarin group (alignment at approximately 6 months), while former Menthacarin patients showed sustained or even continuously improved outcomes by month 12. At study end, more than 90% of patients were “much or very much improved" in both groups. Menthacarin treatment was well tolerated. Conclusions The favorable effects seen in the FU period suggest that Menthacarin is a valuable treatment option in FD patients who require symptomatic treatment also in the longer term for up to 12 months.

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Modulation of gastrointestinal motility beyond metoclopramide and domperidone

Cited by 22 publications

References 31 publications

Neuromechanism of acupuncture regulating gastrointestinal motility

Neuromechanism of acupuncture regulating gastrointestinal motility

Rational treatment of patients with functional dyspepsia

Menthacarin for long-term treatment of functional dyspepsia – Results from a clinical trial follow-up

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