Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)

Tanase, Yasuhito; Yamada, Yoshihiko; Shinmoto, Hiroshi; Kajihara, Hirotaka; Oonogi, Akira; Yoshizawa, Yoriko; Furukawa, Naoto; Shoji, Hirokazu; Yoshida, Shozo; Sado, Toshiyuki; Oi, Hidekazu; Kobayashi, Hiroshi

doi:10.3892/etm.2011.376

Cited by 27 publications

(33 citation statements)

References 36 publications

(81 reference statements)

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“…In HGSOC, an estrogen receptor pathway may increase the likelihood of LVSI. However, estrogensignaling is less active in OCCC, suggesting alternative mechanisms related to LVSI in OCCC [18]. Clear cell histology is the most common histologic subtype of renal cell carcinoma, and LVSI is suggested to be a prognostic factor for worse survival outcomes in that tumor as well [19,20].…”

Section: Discussionmentioning

confidence: 98%

Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion

Matsuo

Yoshino

Murakami

et al. 2015

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 98%

Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion

Matsuo

Yoshino

Murakami

et al. 2015

Gynecologic Oncology

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“…However, clear cell carcinomas do not express estrogen or progesterone receptors [44] and therefore endometriosis, that can transform into clear-cell ovarian cancer, could became hormone independent during the transformation process [24,45]. Therefore, an interesting dualistic model for the development of endometriosis-associated endometrioid EOC (with E and P receptor positive, and associated with hyperplastic aspects of the ectopic endometrium) and for endometriosis-associated clear cell EOC (E and P receptor negative, and associated with iron-mediated oxidative stress) could be suggested [46,47]. Synchronous endometrial-ovarian carcinomas are expected to be endometrioid hystotype, thus confirming the hormone-dependent pathway.…”

Section: Discussionmentioning

confidence: 99%

Epithelial Ovarian Cancers and Endometriosis

Acién

Velasco²,

Acién³

et al. 2015

Gynecol Obstet Invest

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Aims: To determine the prevalence of endometriosis in epithelial ovarian cancers (EOC) and the association among their histological subtypes and with endometrial carcinoma. Methods: An observational cohort study performed in 192 patients operated on for EOC, 30 women with atypical endometriosis and 17 with p53 positive endometriosis. Data on associated endometriosis and endometrial carcinomas, histological subtypes, tumor stage, clinical and pathological characteristics and survival were analyzed. Results: Twenty cases of EOC (10.4%) had also endometriosis (12.7 in borderline and 9.3% in invasive cases), being a synchronous finding in most cases. Endometriosis associated with serous or mucinous EOC was observed in 2.2 and 2.7% of cases, respectively. However, this association was observed in 50 of endometrioid and 23% of clear cell EOC. Age, parity and tumor stage were lower in endometriosis-associated EOC patients; and all associated cases were type I (Kurman and Shih's classification) and showed better results in survival rate. Endometrial carcinoma was more frequently associated with endometrioid EOC (25%). Conclusions: There is a significant association between endometriosis, including atypical forms, and endometrioid and clear cell carcinomas, but not with other EOC histotypes. The presence of endometriosis in EOC suggests a better prognosis and an intermediate stage within the progression endometriosis-carcinoma.

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“…The previously described events, mediated by oxidative stress and inflammation secondary to the repeated hemorrhage from endometriosis, result in DNA methylation that has been linked to decreased ER expression [83,84]. Some investigators have postulated a dualistic model for the development of EAOC, in which the loss of ER expression marks a pivotal point in the carcinogenic pathway separating the development of estrogen-dependent carcinomas ( i.e ., endometrioid) from estrogen-independent carcinomas ( i.e ., clear cell) [85,86]. While the separation of estrogen-dependent and estrogen-independent EAOC is supported on the basis of morphology and genomics, the details of both pathways remain areas of further investigation [85,86].…”

Section: Pathways Of Carcinogenesismentioning

confidence: 99%

Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis

Worley

Welch

Berkowitz

et al. 2013

IJMS

153

123

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Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, endometriosis is a common gynecologic disorder. While in itself a benign lesion, endometriosis shares several characteristics with invasive cancer, has been shown to undergo malignant transformation, and has been associated with an increased risk of epithelial ovarian carcinoma (EOC). Numerous epidemiologic studies have shown an increased risk of EOC among women with endometriosis. This is particularly true for women with endometrioid and clear cell ovarian carcinoma. However, the carcinogenic pathways by which endometriosis associated ovarian carcinoma (EAOC) develops remain poorly understood. Current molecular studies have sought to link endometriosis with EAOC through pathways related to oxidative stress, inflammation and hyperestrogenism. In addition, numerous studies have sought to identify an intermediary lesion between endometriosis and EAOC that may allow for the identification of endometriosis at greatest risk for malignant transformation or for the prevention of malignant transformation of this common gynecologic disorder. The objective of the current article is to review the current data regarding the molecular events associated with EAOC development from endometriosis, with a primary focus on malignancies of the endometrioid and clear cell histologic sub-types.

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Modulation of estrogenic action in clear cell carcinoma of the ovary (Review)

Cited by 27 publications

References 36 publications

Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion

Survival outcome of stage I ovarian clear cell carcinoma with lympho-vascular space invasion

Epithelial Ovarian Cancers and Endometriosis

Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis

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