Modulation of epidermal growth factor receptors by human alpha interferon.

Changes in epidermal growth factor receptor expression and response to ligand associated with acquired tamoxifen resistance or oestrogen independence in the ZR-75-1 human breast cancer cell line

“…Our data on EGFR numbers in these variants of the ZR-75-1 line contrast with an earlier report from this laboratory which showed no significant changes in expression of receptors for Interferon a 2c (Martin et al, 1991 (Zoon et al, 1986;Hamburger & Pinnamaneni, 1991).…”

Recombinant gamma interferon provokes resistance of human breast cancer cells to spontaneous and IL-2 activated non-MHC restricted cytotoxicity

“…A very attractive hypothesis would be that HLA class I molecules are in close association with NK or LAK target structures. This hypothesis is substantiated by a number of reports which indicated that several molecules are associated with HLA class I at the cell surface, including the insulin receptor (Chvatchko et al, 1983), the IL-2 receptor (Szollosi et al, 1987) and the EGF receptor (Schreiber et al, 1984), and are modulated by IFN-y (Pfeffer et al, 1987;Zoon et al, 1986).…”

Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-β

“…Downregulation of expression of speci®c genes by IFNs may also negatively regulate growth (Pestka et al, 1987). This possibility is suggested by several lines of evidence: (1) IFNs down-regulate expression of growth factor receptors thereby antagonizing the growth promoting eects of speci®c growth factors (Zoon et al, 1986); (2) IFNs inhibit the activity of ornithine decarboxylase which is a rate-limiting enzyme in the biosynthesis of polyamines (Sreevalsan et al, 1980;Sekar et al, 1983); and (3) IFNs inhibit genes involved in cell growth (Harel-Bellam et al, 1988;Chatterjee and Savarese, 1992). These results suggest that multiple mechanisms may underlie the ability of IFNs to inhibit cell growth.…”