Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

Lenders, Vincent; Koutsoumpou, Xanthippi; Phan, Philana; Soenen, Stefaan J.; Allegaert, Karel; Vleeschouwer, Steven De; Toelen, Jaan; Zhao, Zongmin; Manshian, Bella B.

doi:10.1039/d1cs00574j

Cited by 4 publications

(3 citation statements)

References 469 publications

(466 reference statements)

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“…It has been widely reported that the presence of PEG shell could decrease the interactions between the biological environment and the PEG-functionalized nanomaterials. The circulation of PEG-modified materials was found to be longer as compared to the nanomaterials without surface functionalization [ 45 – 47 ]. As a classical surface functionalization approach, DSPE-PEG2000 modification has been widely applied in the decoration of various nanomaterials, enabling their stability and prolong blood circulation [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Selenium-integrated conjugated oligomer nanoparticles with high photothermal conversion efficiency for NIR-II imaging-guided cancer phototheranostics in vivo

Yang,

Gao,

Wei

et al. 2023

J Nanobiotechnol

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Second near-infrared (NIR-II) fluorescence imaging in the range of 1000–1700 nm has great prospects for in vivo imaging and theranostics monitoring. At present, few NIR-II probes with theranostics properties have been developed, especially the high-performance organic theranostics material remains underexploited. Herein, we demonstrate a selenium (Se)-tailoring method to develop high-efficient NIR-II imaging-guided material for in vivo cancer phototheranostics. Via Se-tailoring strategy, conjugated oligomer TPSe-based nanoparticles (TPSe NPs) achieve bright NIR-II emission up to 1400 nm and exhibit a relatively high photothermal conversion efficiency of 60% with good stability. Moreover, the TPSe NPs demonstrate their photothermal ablation of cancer cells in vitro and tumor in vivo with the guidance of NIR-II imaging. It is worth noting that the TPSe NPs have good biocompatibility without obvious side effects. Thus, this work provides new insight into the development of NIR-II theranostics agents.

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Section: Resultsmentioning

confidence: 99%

Selenium-integrated conjugated oligomer nanoparticles with high photothermal conversion efficiency for NIR-II imaging-guided cancer phototheranostics in vivo

Yang,

Gao,

Wei

et al. 2023

J Nanobiotechnol

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“…Liver fibrosis is one of the global health problems due to its high prevalence worldwide; in addition, the curative treatments available are very limited (Peng et al 2021;Devarbhavi et al 2023). Liver fibrosis results from the chronic damage to the liver along with the accumulation of extracellular cell matrix (ECM) proteins, which is characteristic of most chronic liver diseases (Lenders et al 2023). The fibrotic liver is characterized by the activation and proliferation of hepatic stellate cells (HSCs), which result in the excessive ECM accumulation and loss of endothelial fenestra and microvilli.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Fe3O4/SiO2/Curcumin Nanohybrid Composites as New Antifibrotic Agents

Taufiq

Nikmah

Subadra

et al. 2023

Preprint

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Liver fibrosis is one of the main threats to human health. To date, antifibrosis drugs encompass several problems, such as the limited treatment effects, lack of drug targeting, and toxic side effects. To increase the therapeutic efficacy in targeting liver fibrosis, scientists should study the development of nanocarriers and effective therapeutic strategies in drug targeting for the treatment of liver fibrosis. In this study, Fe3O4/SiO2/curcumin (Cur) nanohybrid composites have been successfully synthesized and used as antifibrosis drugs in animal liver cells, which were induced with carbon tetrachloride (CCl4). The composition, shape, size, and magnetic properties of the nanocarrier contributed to the successful targeting of antifibrotic agents. Structural studies using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy–energy dispersive X-ray, and transmission electron microscopy were also carried out. The magnetic properties of the nanocarrier to the sensitivity of the external magnetic field were tested using vibrating sample magnetometry. Furthermore, preclinical tests in the form of antibacterial and antifungal tests were performed. From these characterizations, the Fe3O4/SiO2/Cur nanohybrid composites showed good inhibition of bacterial and fungal growth. To determine the efficacy of Fe3O4/SiO2/Cur nanohybrid composites, we conducted serum glutamic oxaloacetic transaminase hytests. Notably, the Fe3O4/SiO2/Cur nanohybrid composites significantly reduced serum alanine transaminase and aspartate transaminase levels (p < 0.05). Thus, the Fe3O4/SiO2/Cur nanohybrid composites can reduce CCl4-induced liver injury.

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“…The blood–brain barrier (BBB) as the major physiological and physical barrier in the CNS prevents the vast majority of drugs from entering the brain. , Therefore, how to efficiently cross the BBB and deliver R848 and chemotherapeutic agents to TAMs and GBM cells specifically is a key challenge. , By taking advantage of inherent transport mechanisms of the BBB, a plethora of conventional brain-targeting drug delivery systems have been developed to overcome the BBB and assist the delivery of drugs to the brain parenchyma. − Among them, receptor-mediated transcytosis (RMT) represents the most popular mechanism given that various receptors are expressed on the BBB endothelium, including low density lipoprotein receptor (LDLR) family members, transferrin receptors, insulin receptors, melanin transferrin, etc. , Specifically, LDLR-related protein 1 (LRP1) is one of the most promising receptors due to abundant expression on both BBB endothelium and GBM cells . Nanoparticles (NPs) modified with a LRP1 recognizing ligand not only could effectively target the BBB but also could target GBM cells after crossing BBB …”

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confidence: 99%

Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma

Jiang,

Li,

Yang

et al. 2024

ACS Nano

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Tumor-associated macrophages (TAMs) are closely related to the progression of glioblastoma multiform (GBM) and its development of therapeutic resistance to conventional chemotherapy. TAM-targeted therapy combined with conventional chemotherapy has emerged as a promising strategy to combat GBM. However, the presence of the blood−brain barrier (BBB) severely limits the therapeutic efficacy. Meanwhile, the lack of ability to distinguish different targeted cells also poses a challenge for precise therapy. Herein, we propose a cathepsin B (CTSB)-responsive programmed brain-targeted delivery system (D&R-HM-MCA) for simultaneous TAM-targeted and GBM-targeted delivery. D&R-HM-MCA could cross the BBB via low density lipoprotein receptorassociated protein 1 (LRP1)-mediated transcytosis. Upon reaching the GBM site, the outer angiopep-2 modification could be detached from D&R-HM-MCA via cleavage of the CTSB-responsive peptide, which could circumvent abluminal LRP1-mediated efflux. The exposed p-aminophenyl-α-D-mannopyranoside (MAN) modification could further recognize glucose transporter-1 (GLUT1) on GBM and macrophage mannose receptor (MMR) on TAMs. D&R-HM-MCA could achieve chemotherapeutic killing of GBM and simultaneously induce TAM polarization from anti-inflammatory M2 phenotype to pro-inflammatory M1 phenotype, thus resensitizing the chemotherapeutic response and improving anti-GBM immune response. This CTSBresponsive brain-targeted delivery system not only can improve brain delivery efficiency, but also can enable the combination of chemo-immunotherapy against GBM. The effectiveness of this strategy may provide thinking for designing more functional brain-targeted delivery systems and more effective therapeutic regimens.

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Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

Abstract: This review discusses the strengths and shortcomings of different strategies to facilitate NP transport across barriers of organs and highlights key findings that can stimulate further advances in this field.

Cited by 4 publications

References 469 publications

Selenium-integrated conjugated oligomer nanoparticles with high photothermal conversion efficiency for NIR-II imaging-guided cancer phototheranostics in vivo

Selenium-integrated conjugated oligomer nanoparticles with high photothermal conversion efficiency for NIR-II imaging-guided cancer phototheranostics in vivo

Fabrication of Fe3O4/SiO2/Curcumin Nanohybrid Composites as New Antifibrotic Agents

Cathepsin B-Responsive Programmed Brain Targeted Delivery System for Chemo-Immunotherapy Combination Therapy of Glioblastoma

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