Modulation of EEG Frequency Characteristics by Low-Intensity Focused Ultrasound Stimulation in a Pentylenetetrazol-Induced Epilepsy Model

Abstract

Treatments for epilepsy include pharmacotherapy or surgery. Recently, focused ultrasound stimulation has been investigated as a promising non-invasive neuromodulation tool for neurological disorders, including epilepsy. To investigate the neuronal dynamics in epilepsy, we acutely stimulated 29 Sprague-Dawley rats to low-intensity focused ultrasound stimulation (LIFUS) three times for 3 minutes. Pentylenetetrazol (PTZ) was injected into the abdominal cavity of the anesthetized rats to induce epilepsy. During the anesthesia, the electroencephalography (EEG) signal was measured and analyzed for 1 h in groups of animals untreated (sham) and treated with LIFUS. The EEG signal was quantitatively processed to show the different characteristics of the frequency change over time and of the band power between sham and treated groups. Histological analyses (Nissl, Iba1, c-Fos, and GAD65) measured the degree of staining of expression factors to confirm the effect of the stimulation on seizure suppression. These results suggest that repetitive LIFUS can effectively reduce epileptic seizure activity by attenuating theta and betaband oscillation in a PTZ-induced rat model. LIFUS can potentially facilitate hippocampal and cortical cellular recovery by augmenting GABAergic inhibitory neurons via its anti-seizure effect.

Design of an improved soft computing model for EEG classification using MFCC and quad classifier

“…To additionally foster flexibility, work in [7] proposes plan of Multiple repeat Multilayer Neural Network (MFMBN) that assists with achieving higher accuracy and favored versatility over as of late proposed models. Equivalent models that utilization CNN with cross wavelet change (XWT) [8], Local Binary Pattern Transition Histogram (LBP TH) [9], and Multivariate Scale Mixture Model (MSMM) [10] are proposed by researchers. These models utilize expanded component extraction techniques for additional growing for the most part portrayal execution during epilepsy disclosure.…”