Modulation of Dorsolateral Prefrontal Delay Activity during Self-Organized Behavior

Procyk, Emmanuel; Goldman‐Rakic, Patricia S.

doi:10.1523/jneurosci.2157-06.2006

Cited by 76 publications

(104 citation statements)

References 56 publications

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“…Monkeys were trained in a problem solving task (PST) (Procyk and Goldman-Rakic, 2006); they had to find by trial and error which target, presented in a set of four, was rewarded ( Fig. 1 A, B).…”

Section: Methodsmentioning

confidence: 99%

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Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Vezoli

Procyk²

2009

J. Neurosci.

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Feedback monitoring and adaptation of performance involve a medial reward system including medial frontal cortical areas, the medial striatum, and the dopaminergic system. A considerable amount of data has been obtained on frontal surface feedback-related potentials (FRPs) in humans and on the correlate of outcome monitoring with single unit activity in monkeys. However, work is needed to bridge knowledge obtained in the two species. The present work describes FRPs in monkeys, using chronic recordings, during a trial and error task. We show that frontal FRPs are differentially sensitive to successes and failures and can be observed over long-term periods. In addition, using the dopamine antagonist haloperidol we observe a selective effect on FRP amplitude that is absent for pure sensoryrelated potentials. These results describe frontal dopaminergic-dependent FRPs in monkeys and corroborate a human-monkey homology for performance monitoring signals.

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Section: Methodsmentioning

confidence: 99%

“…Optimal performances were calculated for an ideal situation where errors in search are not repeated and the correct response is repeated without errors (Procyk and Goldman-Rakic, 2006).…”

Section: Methodsmentioning

confidence: 99%

Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Vezoli

Procyk²

2009

J. Neurosci.

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“…This relationship with cortical motor areas resembles connections from the dorsolateral PFC (dlPFC), suggesting that both areas influence downstream motor areas during the selection, preparation, and execution of actions (5)(6)(7)(8). Despite numerous studies demonstrating the involvement of the dlPFC in various aspects of behavioral control (9)(10)(11)(12), however, little is known about the role of the pmPFC in the performance of motor behaviors.…”

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confidence: 99%

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

Matsuzaka

Akiyama

Tanji

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The functional roles of the primate posterior medial prefrontal cortex have remained largely unknown. Here, we show that this region participates in the regulation of actions in the presence of multiple response tactics. Monkeys performed a forelimb task in which a visual cue required prompt decision of reaching to a left or a right target. The location of the cue was either ipsilateral (concordant) or contralateral (discordant) to the target. As a result of extensive training, the reaction times for the concordant and discordant trials were indistinguishable, indicating that the monkeys developed tactics to overcome the cue-response conflict. Prefrontal neurons exhibited prominent activity when the concordant and discordant trials were randomly presented, requiring rapid selection of a response tactic (reach toward or away from the cue). The following findings indicate that these neurons are involved in the selection of tactics, rather than the selection of action or monitoring of response conflict: (i) The response period activity of neurons in this region disappeared when the monkeys performed the task under the behavioral condition that required a single tactic alone, whereas the action varied across trials. (ii) The neuronal activity was found in the dorsomedial prefrontal cortex but not in the anterior cingulate cortex that has been implicated for the response conflict monitoring. These results suggest that the medial prefrontal cortex participates in the selection of a response tactic that determines an appropriate action. Furthermore, the observation of dynamic, task-dependent neuronal activity necessitates reconsideration of the conventional concept of cortical motor representation.cortical plasticity | frontal executive function T he primate dorsomedial prefrontal cortex (PFC), and particularly its posterior region (pmPFC), is intimately connected with higher-order cortical motor areas in the frontal lobe, including the presupplementary motor area (pre-SMA), the rostral cingulate motor area, and the dorsal premotor area (1-4). This relationship with cortical motor areas resembles connections from the dorsolateral PFC (dlPFC), suggesting that both areas influence downstream motor areas during the selection, preparation, and execution of actions (5-8). Despite numerous studies demonstrating the involvement of the dlPFC in various aspects of behavioral control (9-12), however, little is known about the role of the pmPFC in the performance of motor behaviors.A few studies have attempted to explore this area. For example, Petrides proposed that the dorsomedial PFC plays important roles in monitoring multiple events and self-ordering actions (13), although his later study suggested that the dlPFC is also involved in this process (14). Bon and Lucchetti reported that electrical stimulation in area 8b evoked ear or eye movements, and neurons in this region showed activity modulation related to these types of movements (15, 16). Human brain-imaging studies identified active areas including the mPFC that were re...

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“…Estas tres áreas forman parte de la corteza prefrontal dorsolateral (DL-PFC) que es el área cortical responsable de la planificación, organización y regulación motora. Además, tiene un rol importante en la integración tanto de la información sensorial y mnemónica como en la regulación de la acción y función intelectual; también está involucrada en la memoria de trabajo (12)(13)(14) .…”

Section: Discussionunclassified

Obtención De Coordenadas Talairach a Partir De Mapas Corticales De Area Visual Con Resonancia Magnética Funcional

Rojas

et al. 2008

Rev. chil. radiol.

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Modulation of Dorsolateral Prefrontal Delay Activity during Self-Organized Behavior

Cited by 76 publications

References 56 publications

Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Frontal Feedback-Related Potentials in Nonhuman Primates: Modulation during Learning and under Haloperidol

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

Obtención De Coordenadas Talairach a Partir De Mapas Corticales De Area Visual Con Resonancia Magnética Funcional

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