Modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats

Blaha, C. D.; Winn, Philip

doi:10.1523/jneurosci.13-03-01035.1993

Cited by 136 publications

(69 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Local administration of nicotine into the substantia nigra and ventral tegmental area has been shown to evoke DA release in striatum and nucleus accumbens, respectively, via stimulation of nAChRs in the cell body region (Blaha and Winn, 1993;Sziraki et al, 2002). Additionally, the effect of peripheral administration of nicotine to increase DA release in the nucleus accumbens determined using microdialysis was inhibited by local administration of mecamylamine into the ventral tegmental area (Sziraki et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex

Middleton

Cass²,

Dwoskin³

2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Nicotine activates nicotinic acetylcholine receptors (nAChRs) on dopamine (DA) terminals to evoke DA release, which subsequently is taken back up into the terminal via the DA transporter (DAT). nAChRs may modulate DAT function thereby contributing to the regulation of synaptic DA concentrations. The present study determined the dose-response for nicotine (0.1-0.8 mg/kg, s.c.) to modulate DA clearance in striatum and medial prefrontal cortex (mPFC) using in vivo voltammetry in urethane anesthetized rats and determined if this effect was mediated by nAChRs. Exogenous DA (200 M) was pressureejected at 5-min intervals until reproducible baseline signals were obtained. Subsequently, nicotine or saline was administered, and DA pressure ejection continued at 5-min intervals for 60 min. In both striatum and mPFC, signal amplitude decreased by ϳ20% across the 60-min session in saline-injected rats. A monophasic dose-response curve was found in striatum, with a maximal 50% decrease in signal amplitude after 0.8 mg/kg. In contrast, a U-shaped dose-response curve was found in mPFC, with a maximal 50% decrease in signal amplitude after 0.4 mg/kg. Onset of nicotine response occurred 10 to 15 min after injection in both brain regions; however, the amount of time before maximal response was 45 and 30 min in striatum and mPFC, respectively. Mecamylamine (1.5 mg/kg) completely inhibited the nicotine-induced (0.8 and 0.4 mg/kg) decrease in signal amplitude in striatum and mPFC, respectively, indicating mediation by nAChRs. Thus, nicotine enhances DA clearance in striatum and mPFC in a mecamylamine-sensitive manner, indicating that nAChRs modulate DAT function in these brain regions.Previous research on the neurobiology of reward and drug addiction has focused on the mesocorticolimbic and nigrostriatal dopamine (DA) systems, emphasizing the role of the nucleus accumbens, medial prefrontal cortex (mPFC), and striatum. The accumbens shell, which is innervated by dopaminergic projections from the ventral tegmental area, and its associated neurocircuitry are believed to encode primary appetitive stimuli associated with unconditioned drug reward

show abstract

Section: Discussionmentioning

confidence: 99%

Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex

Middleton

Cass²,

Dwoskin³

2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…Anatomical, electrophysiological, and pharmacological studies indicated that the pedunculopontine tegmental nucleus (PPTN) of the brainstem receives signals from reward related structures, including the cerebral cortices, amygdala, and basal ganglia (Garcia-Rill, 1991;Semba and Fibiger, 1992;Chiba et al, 2001;Mena-Segovia et al, 2004;Winn, 2006), and provides strong excitatory inputs (glutamatergic and acetylcholinergic) to dopamine neurons (Scarnati et al, 1984;Blaha and Winn, 1993;Futami et al, 1995;Oakman et al, 1995;Pan and Hyland, 2005;Mena-Segovia et al, 2008). The PPTN has been shown to respond to the sensory and motor task events rather than the task reward (Matsumura et al, 1997;Pan and Hyland, 2005).…”

Section: Introductionmentioning

confidence: 99%

Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards

Okada

Toyama²,

Inoue³

et al. 2009

J. Neurosci.

102

145

View full text Add to dashboard Cite

The dopamine system has been implicated in guiding behavior based on rewards. The pedunculopontine tegmental nucleus (PPTN) of the brainstem receives afferent inputs from reward-related structures, including the cerebral cortices and the basal ganglia, and in turn provides strong excitatory projections to dopamine neurons. This anatomical evidence predicts that PPTN neurons may carry reward information. To elucidate the functional role of the PPTN in reward-seeking behavior, we recorded single PPTN neurons while monkeys performed a visually guided saccade task in which the predicted reward value was informed by the shape of the fixation target. Two distinct groups of neurons, fixation target (FT) and reward delivery (RD) neurons, carried reward information. The activity of FT neurons persisted between FT onset and reward delivery, with the level of activity associated with the magnitude of the expected reward. RD neurons discharged phasically after reward delivery, with the levels of activity associated with the actual reward. These results suggest that separate populations of PPTN neurons signal predicted and actual reward values, both of which are necessary for the computation of reward prediction error as represented by dopamine neurons.

show abstract

“…Indeed, electrophysiological studies in several mammalian species performing operant motor tasks have found that single PPTg neurons are phasically active at the time of eye ), limb Matsumura et al 1997), and body movements (Norton et al 2011) and in response to reward delivery Kobayashi and Okada 2007;Norton et al 2011;Pan and Hyland 2005). However, the widespread connectivity of the PPTg, as well as its modulation by dopaminergic, serotonergic, and noradrenergic input (Blaha and Winn 1993;Grace et al 2012;Inglis et al 1993;Matulewicz et al 2010;Steiniger and Kretschmer 2004), suggests that the PPTg may contribute more broadly to sensorimotor decision making rather than simply represent motor and reward information (Steckler et al 1994). In this study, we employed a sensory-cued spatial-choice task (Uchida and Mainen 2003) to examine how and when PPTg activity reflects "task-related variables," defined as quantities underlying goaldirected movements in response to sensory stimuli (e.g., movement direction and outcome).…”

mentioning

confidence: 99%

Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task

Thompson

Felsen

2013

Journal of Neurophysiology

View full text Add to dashboard Cite

Recent studies across several mammalian species have revealed a distributed network of cortical and subcortical brain regions responsible for sensorimotor decision making. Many of these regions have been shown to be interconnected with the pedunculopontine tegmental nucleus (PPTg), a brain stem structure characterized by neuronal heterogeneity and thought to be involved in several cognitive and behavioral functions. However, whether this structure plays a general functional role in sensorimotor decision making is unclear. We hypothesized that, in the context of a sensorimotor task, activity in the PPTg would reflect task-related variables in a similar manner as do the cortical and subcortical regions with which it is anatomically associated. To examine this hypothesis, we recorded PPTg activity in mice performing an odor-cued spatial choice task requiring a stereotyped leftward or rightward orienting movement to obtain a reward. We studied single-neuron activity during epochs of the task related to movement preparation, execution, and outcome (i.e., whether or not the movement was rewarded). We found that a substantial proportion of neurons in the PPTg exhibited direction-selective activity during one or more of these epochs. In addition, an overlapping population of neurons reflected movement direction and reward outcome. These results suggest that the PPTg should be considered within the network of brain areas responsible for sensorimotor decision making and lay the foundation for future experiments to examine how the PPTg interacts with other regions to control sensory-guided motor output.

show abstract

Modulation of dopamine efflux in the striatum following cholinergic stimulation of the substantia nigra in intact and pedunculopontine tegmental nucleus-lesioned rats

Cited by 136 publications

References 39 publications

Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex

Nicotinic Receptor Modulation of Dopamine Transporter Function in Rat Striatum and Medial Prefrontal Cortex

Different Pedunculopontine Tegmental Neurons Signal Predicted and Actual Task Rewards

Activity in mouse pedunculopontine tegmental nucleus reflects action and outcome in a decision-making task

Contact Info

Product

Resources

About