Modulation of digestive enzymes, GH, IGF-1 and IGF-2 genes in the teleost, Tilapia (Oreochromis mossambicus) by dietary curcumin

Midhun, Sebastian Jose; Arun, Damodaran; Edatt, Lincy; Sruthi, Maguluru; Thushara, V. V.; Oommen, Oommen V.; Kumar, Vijai; Divya, Lekha

doi:10.1007/s10499-016-9984-1

Cited by 62 publications

(42 citation statements)

References 36 publications

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“…Curcumin is considered as a prebiotic that can improve the balance of positive and negative intestinal flora [27] and it can increase the intestinal digestion and absorption that leads to stimulate the growth and improve the general health of fish [25]. The current results are in agreement with Midhun et al [28] who reported an increase in GH, GHR and IGF when curcumin has been used as feed additive to tilapia for 45 days. Rojtinnakorn et al [29] showed that all turmeric extract fed fish had significant higher activities of digestive enzymes because it considered as an indicator on improvement of growth rate.…”

Section: Discussionsupporting

confidence: 90%

Effect of Turmeric (Curcuma longa) Black Pepper (Piper nigrum) and Azolla Pinnata on Waste Water Nile tilapia Fish

Dowidar

El-Megid

EL-Werwary

2017

Zagazig Veterinary Journal

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Section: Discussionsupporting

confidence: 90%

Effect of Turmeric (Curcuma longa) Black Pepper (Piper nigrum) and Azolla Pinnata on Waste Water Nile tilapia Fish

Dowidar

El-Megid

EL-Werwary

2017

Zagazig Veterinary Journal

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“…Consistently, the results from this study showed that fish fed on diets supplemented with 400 and 600 ppm limonene exhibited increased mRNA levels of igf-I, final weights, growth rates and percentage weight gain (% WG) compared to the control, implying that igf-I accounted for improved growth of the fish. Previous observations on enhanced levels of igf-I by dietary limonene (Miller et al, 2013) (Midhun et al, 2016). Interestingly, our results showed that the final weight of the fish was influenced by an interaction between increasing number of days of the experiment and concentration of limonene.…”

Section: Discussionsupporting

confidence: 57%

Effects of dietary limonene and thymol on the growth and nutritional physiology of Nile tilapia ( Oreochromis niloticus )

2018

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Phytogenic compounds such as limonene and thymol have been shown to have growthpromoting properties in farmed animals but studies in fish are scarce. Two Experiments (Experiments I and II) were carried out to investigate the individual effects of dietary limonene and thymol on the growth and nutritional physiology of juvenile Nile tilapia (Oreochromis niloticus). In Experiment I, the fish were fed on a commercial diet coated with limonene at 0 (control), 200, 400, and 600 mg kg-1 (ppm), while in Experiment II thymol was supplemented in the diet at 0 (control), 250 and 500 ppm. Our results showed a significant increase in fish weight and weight gain with diets supplemented with 400 and 600 ppm limonene compared to the control. Moreover, the expression of insulin growth factor I (igf-I), mucin-like protein (muc), oligo-peptide transporter I (pept1), lipoprotein lipase (lpl), alkaline phosphatase (alp) and catalase (cat) was up-regulated by dietary limonene. Our results confirm that dietary limonene can enhance the growth of Nile tilapia juveniles through the activation of key genes involved in somatotropic axis-mediated growth, nutrient digestion and antioxidant enzyme defence. Dietary thymol did not seem to influence growth or regulate the same pathways activated by limonene in Nile tilapia juveniles at inclusion levels up to 500 ppm. Overall, the present results suggest that potential growth-promoting effects are dependent upon the phytogenetic itself and its inclusion level.

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“…In fact, it was demonstrated that in Atlantic Salmon, a high value of this ratio means an enhance of growth rate and vice versa (Rungruangsak‐Torrissen et al 2006). Similar results were also found in other fish and shrimps with improved activity of protease while fed turmeric or curcumin (Jiang et al 2016; Midhun et al 2016). Lipase and amylase usually increase their activity in stomach, hepatopancreas and intestine when fed with turmeric or its components in fish, shrimps and even in rats (Poongodi et al 2012; Mahmood 2015).…”

Section: Discussionsupporting

confidence: 83%

“…These functions are linked to nerves centres which are stimulated by the sense of smell and by the presence of attractive principles in the diet (Platel & Srinivasan 2004). Midhun et al (2016) reported in O. niloticus , a significant increase in growth hormones expression in the brain when fed 0.5% and 1% of curcumin. Growth hormones are involved in the stimulation of DNA, RNA and protein synthesis and indirectly affect the release of IGF1 and IGF2.…”

Section: Discussionmentioning

confidence: 99%

“…Digestive enzymes are key components of digestion process in fish. Improved activities of many enzymes including protease, lipase and amylase were noticed for turmeric and curcumin supplementation in fish diet (Jiang et al 2016; Midhun et al 2016; Pransin 2006; Rojtinnakorn et al, 2012). These enzymes play crucial role in the degradation of protein, lipids and carbohydrates.…”

Section: Discussionmentioning

confidence: 99%

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Meta‐analysis of dietary supplementation effect of turmeric and curcumin on growth performance in fish

Fagnon

Thorin

Calvez

2020

Reviews in Aquaculture

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Plant‐based additives are currently used in aquaculture for their various beneficial properties. Curcumin and turmeric are usually applied for their interesting results on growth performance of fish. In this paper, the effect of dietary inclusion of curcumin and turmeric powder on growth performance in fish was studied. Twenty data sets from 5 studies and 29 data sets from 8 publications were respectively computed for curcumin and turmeric in this analysis. Specific growth rate (SGR) was the quantitative criteria recorded for each data set. After, a brief systemic summary of each study, the quantitative analysis was performed. Results showed a significant increase in pooled standard mean difference (SMD) for both fixed and random model in curcumin and turmeric. Although fish species were categorized into family (subcategory), high heterogeneity (>96%) was found in all random and fixed model analysis. Contrary to turmeric, higher curcumin inclusion results in lower specific growth rate. The higher effect sizes observed when fed curcumin at lower inclusion levels suggests that feeding low levels of phytochemicals might be beneficial and its content in turmeric should be analysed for quite homogeneous feed. This study contributes to the analysis of overall growth performance properties of turmeric and curcumin incorporation in fish diet, irrespective to their strong antioxidant and anti‐inflammatory activities.

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Modulation of digestive enzymes, GH, IGF-1 and IGF-2 genes in the teleost, Tilapia (Oreochromis mossambicus) by dietary curcumin

Cited by 62 publications

References 36 publications

Effect of Turmeric (Curcuma longa) Black Pepper (Piper nigrum) and Azolla Pinnata on Waste Water Nile tilapia Fish

Effect of Turmeric (Curcuma longa) Black Pepper (Piper nigrum) and Azolla Pinnata on Waste Water Nile tilapia Fish

Effects of dietary limonene and thymol on the growth and nutritional physiology of Nile tilapia ( Oreochromis niloticus )

Meta‐analysis of dietary supplementation effect of turmeric and curcumin on growth performance in fish

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