Modulation of cytotoxicity and enhancement of cytokine release induced by Viscum album L. extracts or mistletoe lectins

Ribéreau-Gayon, G.; Jung, Marie‐Louise; Frantz, Marianne; Anton, Robert

doi:10.1097/00001813-199704001-00002

Cited by 45 publications

(31 citation statements)

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“…Lima et al (1993) have previously reported strong inflammatory response and leukocyte influx to the site of injection upon subcutaneous administration of high doses of DGL, involving venule necrosis and hemorrhagic appearance. The reaction, similar to the effects of immune complex deposition, may have the participation of TNF-α, which has been shown to be produced upon in vitro lectin stimulation (Hajto et al 1990, Amore et al 1993, Ribereau-Gayon et al 1997.…”

Section: Discussionmentioning

confidence: 99%

In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

Bessa

Arruda

Cavada

et al. 2001

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

Bessa

Arruda

Cavada

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…Moreover, the effect of ML during subcutaneous mistletoe therapy of cancer might be altered by the induction of anti-ML-antibodies [20,110,111] and the inhibition of MLs by serum glycoproteins/-lipids [108]. Thus, a more clinically relevant ML-mediated effect might be induced in the case of intratumoral or intrapleural injection [8].…”

Section: Perioperative Mistletoe Infusionmentioning

confidence: 99%

Immunomodulatory Effects of <i>Viscum album</i> Extracts on Natural Killer Cells: Review of Clinical Trials

Braedel-Ruoff¹

2010

Forsch Komplementmed

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Extracts produced from Viscum album L. (mistletoe) are widely used in complementary medicine for the treatment of cancer. In many preclinical and clinical studies, Viscum album extracts were shown to exert immunomodulatory functions. Natural killer (NK) cells play an important role in cell-mediated immune responses against tumor cells. This article reviews clinical trials that address the influence of the mistletoe extract Iscador^® on NK cells and discusses the results with regard to the NK cell functions assayed, to putative underlying mechanisms, and to the role of different mistletoe components. Conclusion: Although many trials demonstrated a positive effect of Iscador^® treatment on NK cell function, further dedicated studies with optimized treatment schedules and comparable mistletoe doses are necessary to confirm these results regarding involvement of NK cells on the immunomodulatory functions of Iscador^® therapy and to investigate the clinical relevance of these findings.

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“…In contrast to chemokines, cytokine modulations by mistletoe have been discussed intensively (Hajto et al, 1990;Joshi et al, 1991;Männel et al, 1991;Hostanska et al, 1995;Hostanska et al, 1996;Möckel et al, 1997;Riberéau-Gayon et al, 1997;Yoon et al, 2001). Thirty three genes on the array that code for proteins with cytokine activity were identified.…”

Section: Discussionmentioning

confidence: 99%

Effect of Korean Mistletoe Lectin on Gene Expression Profile in Human T Lymphocytes: A Microarray Study

Lyu¹,

Park

2010

Biomolecules and Therapeutics

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-Korean mistletoe has a variety of biological effects, such as immunoadjuvant activities. This study investigates the effects of Korean mistletoe lectin (Viscum album L. var. coloratum agglutinin, VCA) on human T lymphocytes to determine whether VCA acts as an immunomodulator. Purified human T-lymphocytes were cultured with VCA and RNA from each point was analyzed using Affymetrix human genome chips containing 22,500 probe sets which represents more than 18,000 transcripts derived from 14,500 human genes. As a result, there was a striking upregulation of genes coding for chemokines. Seventeen genes out of 50 coding for proteins with chemokine activity were upregulated including CXCL9 and IL-8 which are related to the treatment of cancer. In addition, 28 cytokine genes were upregulated including IL-1, IL-6, IL-8, IFN-γ, and TNF-α. Taken together, the data suggest that Korean mistletoe lectin, in parallel with European mistletoe, has an ability to modulate human T cell function.

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Modulation of cytotoxicity and enhancement of cytokine release induced by Viscum album L. extracts or mistletoe lectins

Cited by 45 publications

References 0 publications

In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

Immunomodulatory Effects of <i>Viscum album</i> Extracts on Natural Killer Cells: Review of Clinical Trials

Effect of Korean Mistletoe Lectin on Gene Expression Profile in Human T Lymphocytes: A Microarray Study

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