Modulation of cytokines production, granzyme B and perforin in murine CIK cells by Ganoderma lucidum polysaccharides

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

“…G. lucidum polysaccharides were shown to induce apoptosis, inhibit cell proliferation and suppress cell migration of highly invasive human prostate cancer cells. The mechanism of antitumor activity of G. lucidum polysaccharides proceeded through stimulation of host defence responses (14,15). Our earlier …”

“…G. lucidum is traditionally used for the prevention and treatment of a large number of diseases, including many forms of cancer. G. lucidum extracts and polysaccharides were also proven to have, along with antitumor, also immune potentiating activities (14,15). G. lucidum polysaccharides were shown to induce apoptosis, inhibit cell proliferation and suppress cell migration of highly invasive human prostate cancer cells.…”

Antioxidant and immunoregulatory activity of polysaccharides from adzuki beans (Vigna angularis)

“…Polysaccharides from natural sources have attracted increasing attention in recent years due to their potential biological functions, especially their antioxidant and immunomodulation activities, such as scavenging free radical, inhibiting lipid oxidation, promoting natural killer (NK) cell cytotoxicity, activating macrophages and potentiating interleukins (Song, Zhang, Zhang, & Wang, 2010;Yang, Zhao, & Lv, 2008;Zhu & Lin, 2006). The bioactivity of polysaccharides mainly depends on several structural parameters, including the sugar composition, molecular weight, type of glycoside bond, and degree of sulfation (Li, Huang, Lu, & Hou, 2011).…”

Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice

“…Gl polysaccharides (Gl-PS), a glycopeptide isolated from the water-soluble polysaccharides of Gl, is a major effective component of Gl (Lin, 2001). Our and some others previous studies have demonstrated that Gl-PS exhibit immunomodulatory and anti-tumor effects (Hou et al, 1995;Zhang et al, 2002;Bao et al, 2002;Lin and Zhang, 2004;Gao et al, 2005;Sung et al, 2005;Zhu and Lin, 2005;Zhu and Lin, 2006). Cyclophosphamide (Cy) is the most widely used alkylating agent in cancer chemotherapy to date.…”