Modulation of cortical inhibition by rTMS – findings obtained from animal models

Funke, Klaus; Benali, Alia

doi:10.1113/jphysiol.2011.206573

Cited by 147 publications

(112 citation statements)

References 74 publications

(122 reference statements)

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“…Also, long-term rTMS treatment was associated with increased prefrontal white matter FA (Allendorfer et al, 2012;Peng et al, 2012). Cortical inhibition has been suggested to explain the lasting effects of rTMS (Daskalakis et al, 2006;Funke and Benali, 2011). Therefore, GAD1 genotype could predict a direct mechanistic link between rTMS treatment and DLPFC LICI.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory

Lett

Kennedy

Radhu

et al. 2016

Neuropsychopharmacol

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The glutamic acid decarboxylase 1 (GAD1) gene is a major determinant of γ-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter modulating local neuronal circuitry. GABAergic dysfunction and expression of GAD1 have been implicated in the pathophysiology of schizophrenia, and in working memory impairment. We examined the influence of the functional GAD1 rs3749034 variant on white matter fractional anisotropy (FA), cortical thickness, and working memory performance in schizophrenia patients and healthy controls (N = 197). Using transcranial magnetic stimulation with electroencephalography (TMS-EEG), we subsequently examined the effect of rs3749034 on long-interval cortical inhibition (LICI) in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia patients and healthy controls (N = 66). We found that the rs3749034 T-allele carrier risk group had lower voxel-wise FA in the prefrontal cortex region (P FWE-corrected o0.05) but not cortical thickness. Mixed-model regression revealed a significant effect on attentional processing and working memory across four performance measures (F 1,182 = 11.5, P = 8 × 10 − 4 ). FA in the prefrontal cortex was associated with digit-span performance. Voxel-wise mediation analysis revealed that the effect GAD1 on poorer digit-span performance statistically predicted the lower white matter FA (P FWE-corrected o0.05). In exploratory analysis, we found a prominent GAD1 genotype-by-diagnosis interaction on DLPFC LICI (F 1,56 = 14.3, P = 4.1 × 10 − 4 ). Our findings converge on variation in GAD1 gene predicting a susceptibility mechanism that affects white matter FA, GABAergic inhibitory neurotransmission in the DLPFC, and working memory performance. Furthermore, via voxel mediation of FA and TMS-EEG intervention, we provide evidence for a potentially causal mechanism through which aberrant DLPFC GABA signaling may contribute to working memory dysfunction.

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Section: Discussionmentioning

confidence: 99%

Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory

Lett

Kennedy

Radhu

et al. 2016

Neuropsychopharmacol

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“…In the opinion of some authors who have studied the modulatory effects of rTMS, the reduction of the expression of the proteins that are specific to interneurons is connected with a decrease in the signals arriving from excitable systems as a result of long-term postsynaptic depression occurring during magnetic stimulation [5].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Repetitive Transcranial Magnetic Stimulation on Picrotoxin-Induced Convulsions in Mice

et al. 2016

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“…(2) The mechanisms of rTMS are related to its ability to cause long-term effects of postsynaptic inhibition in excitatory neurotransmitter systems, and a reduction in neuronal excitability through inactivation of the voltagedependent ion channels. (29) Based on the data published till now and taking all restrictions into account, a group of European experts assigned evidentiary class C (probably effective) to the low-frequency mode of epileptic focus stimulation in cases where its location is in the cortex or in proximity to cortex dysplasia. (30) …”

Section: Deep Brain Stimulationmentioning

confidence: 99%

The Role of Non-Drug Treatment Methods in the Management of Epilepsy

Narodova¹,

Shnayder²,

Narodova³

et al. 2018

IJBM

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This review is dedicated to the issue of non-pharmacological treatment of epilepsy in the adult population in Russia and other countries. A literature review was conducted using international databases for the period between 2010 and 2017. A total of 64 full-text editions were included in this review, which allowed us to reveal the basic non-pharmacological epilepsy treatment options. However, not all of these options have a sufficient evidence base, and some of them are not always safe. Particularly, methods with a low level of evidence include acupuncture and aromatherapy. Further studies are needed to explore the methods aimed at eliminating the dominant epileptic system through the development of a new, more powerful dominant system. One of the methods that can influence the pathogenesis of epilepsy is physical activity for patients with epilepsy, since epileptiform activity is reported to disappear from the EEG during exercises. The positive results of the application of music therapy are also described in the modern literature. Specifically, according to the results of some studies, the positive effect of reducing the frequency of seizures was achieved in epileptic patients who listened to music during sleep over a year. However, these studies are not numerous, so they cannot constitute a high level of evidence. Therefore, care should be exercised in applying these methods in epileptic patients. (International Journal of Biomedicine. 2018;8(1):9-14.)

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Modulation of cortical inhibition by rTMS – findings obtained from animal models

Cited by 147 publications

References 74 publications

Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory

Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory

The Effects of Repetitive Transcranial Magnetic Stimulation on Picrotoxin-Induced Convulsions in Mice

The Role of Non-Drug Treatment Methods in the Management of Epilepsy

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