Modulation of CD4+ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis

Abstract

SummaryDysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, as thrombocytopenia is a complication of HCV-related liver cirrhosis (LC), due to splenic platelet sequestration and bone marrow suppression; splenectomy has been proposed to treat such patients. Herein, we studied peripheral blood mononuclear cells (PBMC) and splenic lymphoid subpopulations from a total of 22 patients, including 15 with HCV-related LC with marked thrombocytopenia treated with splenectomy, and seven controls.

Case report on the role of radiofrequency-assisted spleen-preserving surgery for splenic metastasis in the era of check-point inhibitors

“…Splenic preservation would assist in maintaining the physiological functionality of T cells and as a consequence keep the optimal efficacy of check point inhibitors. [29][30][31][32][33][34][35] Our patient in this index report developed pneumonitis, an uncommon complication encountered with an antiprogrammed cell death receptor 1 (PD-1) or anti-programmed cell death ligand 1 (PD-L1) monoclonal antibody. However, drug-induced pneumonitis is a diagnosis of exclusion, and alternative diagnoses, including infection and malignancy, need to be sought first.…”

Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway

“…transforming growth factor (TGF)-β1, whereas others play an antifibrotic role, i.e. interleukin (IL)-10, interferon (IFN)-γ [3][4][5][6][7]. Moreover, HSCs with dual effects of antigenpresentation and collagen synthesis are recently reported to be involved in regulating CD4 + T cell responses [10,11].…”

“…Recently, accumulating evidence from mouse and human studies have emphasized the crucial role of infiltrating CD4 + T cells in the progression of liver inflammation and fibrosis [1,[5][6][7]. It has become clear that CD4 + T cells have heterogeneous effects for the existence of diverse functional subsets [1,[5][6][7].…”

“…It has become clear that CD4 + T cells have heterogeneous effects for the existence of diverse functional subsets [1,[5][6][7]. CD4 + T helper cells have recently been subdivided into four major subsets, largely based on their expression profile of transcription factors and secreted cytokines: T helper (Th) cell type 1, Th2, Th17 and regulatory T cells (Tregs) [8,9].…”

The First Case of Deceased Donor Liver Transplantation for a Patient with End-Stage Liver Cirrhosis Due to Human Immunodeficiency Virus and Hepatitis C Virus Coinfection in Japan

“…Therefore, a splenectomy may not significantly increase the CD4 count before LT. However, Hashimoto et al reported that the CD4 function, in terms of IFN-gamma production and CD4 proliferation, increased after splenectomy (11). Accordingly, it is still controversial whether splenectomy should be performed before LT for patients with HIV infection in order to increase the number or function of CD4 cells.…”