Modulation of Caudate Activity by Action Contingency

Tricomi, Elizabeth; Delgado, Mauricio R.; Fiez, Julie A.

doi:10.1016/s0896-6273(03)00848-1

Cited by 497 publications

(448 citation statements)

References 51 publications

(3 reference statements)

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“…Salience activated a network of brain areas involved in arousal, attention, and uncertainty processing, including precuneus, parietal cortex, thalamus, amygdala, and insula (Huettel et al, 2005;Simmons et al, 2004). Salient trials also activated bilateral dorsal striatum, including caudate and globus pallidus, consistent with earlier studies investigating areas that support salience or contingency detection (Tricomi et al, 2004;Zink et al, 2006). By contrast, increasing valence activated a network of brain regions linked to reward representations, including mesial prefrontal cortex , orbitofrontal cortex (O'Doherty et al, 2001;Rolls, 2004), and inferior parietal cortex (Ernst et al, 2004;Glimcher et al, 2005).…”

Section: Discussionsupporting

confidence: 86%

“…Independently manipulating these two factors allowed us to separately examine each factor's influence on NAcc activation. Earlier studies that have focused on valence, using monetary incentives or aversive shock, have not independently varied salience (Abler et al, 2006;Breiter et al, 2001;Jensen et al, 2007;Knutson et al, 2001;Tobler et al, 2007;Tom et al, 2007), while studies that have varied salience have not independently varied valence across gains and losses (Bjork and Hommer, 2006;Jensen et al, 2003;Tricomi et al, 2004;Zink et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Cue salience might increase with absolute incentive magnitude (good or bad), incentive uncertainty, or the contingency of the response (i.e., how important an organism's response is to the outcome). The salience account references evidence that NAcc activation increases with behavioral demands or interference (Tricomi et al, 2004;Zink et al, 2004;Zink et al, 2006), in response to novel nonrewarded events (Zink et al, 2003), or in anticipation of painful stimulation (Berridge and Robinson, 1998;Jensen et al, 2003). At least two studies have reported NAcc activation correlated with salience prediction error models of conditioning for painful stimuli that included decreases during unpredicted avoidance of painful stimuli (Jensen et al, 2007;Seymour et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Valence and salience contribute to nucleus accumbens activation

Cooper¹,

Knutson²

2008

NeuroImage

232

176

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Different accounts of nucleus accumbens (NAcc) function have emphasized its role in representing either valence or salience during incentive anticipation. In an event-related FMRI experiment, we independently manipulated valence and salience by cuing participants to anticipate certain and uncertain monetary gains and losses. NAcc activation correlated with both valence and salience. On trials with certain outcomes, NAcc activation increased for anticipated gains and decreased for anticipated losses. On trials with uncertain outcomes, NAcc activation increased for both anticipated gains and losses but did not differ between them. These findings suggest that NAcc activation separately represents both valence and salience, consistent with its hypothesized role in appetitive motivation.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Valence and salience contribute to nucleus accumbens activation

Cooper¹,

Knutson²

2008

NeuroImage

232

176

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“…Another difference with the current study is that in Breiter et al's study, the presented outcomes were not in any way contingent upon the participants' choices, or perceived by participants as such; instead, the participants were simply attending to the various stimulus displays. Importantly, recent research has demonstrated that the perception of action-outcome contingencies has a large impact on the (degree of) involvement of various brain areas in reward processing (Tricomi et al, 2004;Walton et al, 2004;Yeung et al, in press).…”

Section: Discussionmentioning

confidence: 99%

Activity in human reward-sensitive brain areas is strongly context dependent

et al. 2005

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Functional neuroimaging research in humans has identified a number of brain areas that are activated by the delivery of primary and secondary reinforcers. The present study investigated how activity in these reward-sensitive regions is modulated by the context in which rewards and punishments are experienced. Fourteen healthy volunteers were scanned during the performance of a simple monetary gambling task that involved a bwinQ condition (in which the possible outcomes were a large monetary gain, a small gain, or no gain of money) and a bloseQ condition (in which the possible outcomes were a large monetary loss, a small loss, or no loss of money). We observed reward-sensitive activity in a number of brain areas previously implicated in reward processing, including the striatum, prefrontal cortex, posterior cingulate, and inferior parietal lobule. Critically, activity in these reward-sensitive areas was highly sensitive to the range of possible outcomes from which an outcome was selected. In particular, these regions were activated to a comparable degree by the best outcomes in each condition-a large gain in the win condition and no loss of money in the lose condition-despite the large difference in the objective value of these outcomes. In addition, some rewardsensitive brain areas showed a binary instead of graded sensitivity to the magnitude of the outcomes from each distribution. These results provide important evidence regarding the way in which the brain scales the motivational value of events by the context in which these events occur. D

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“…Studies consistently implicate caudate in operant responding [28][29][30][31]. It is suggested that while the caudate represents motor responses necessary for simple operant behaviour, object/ motor features are also represented within ventrolateral PFC to allow for more flexible control over motor responding [9,16].…”

Section: Discussionmentioning

confidence: 99%

The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

Mitchell

Rhodes

Pine

et al. 2008

Behavioural Brain Research

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Studies investigating response reversal consistently implicate regions of medial and lateral prefrontal cortex when reinforcement contingencies change. However, it is unclear from these studies how these regions give rise to the individual components of response reversal, such as reinforcement value encoding, response inhibition, and response change. Here we report a novel instrumental learning task designed to determine whether regions implicated in processing reversal errors are uniquely involved in this process, or whether they play a more general role in representing response competition, reinforcement value, or punishment value in the absence of demands for response change. In line with previous findings, reversal errors activated orbitofrontal cortex, dorsomedial prefrontal cortex, ventrolateral prefrontal cortex, caudate, and dorsolateral prefrontal cortex. These regions also showed increased activity to errors in the absence of contingency changes. In addition, ventrolateral PFC, caudate, and dorsolateral PFC each exhibited increased activity following correct reversals. Activity in these regions was not significantly modulated by changes in reinforcement value that were not sufficient to make an alternative response advantageous. These data do not support punishment-processing or prepotent reponse inhibition accounts of ventrolateral prefrontal cortex function. Instead, they support recent conceptualizations of ventrolateral prefrontal cortex function that implicate this region in resolving response competition by manipulating the representation of either motor response options, or object features. These data also suggest that dorsolateral prefrontal cortex plays a role in reversal learning, probably through top down attentional control of object or reinforcement features when task demands increase.

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Modulation of Caudate Activity by Action Contingency

Cited by 497 publications

References 51 publications

Valence and salience contribute to nucleus accumbens activation

Valence and salience contribute to nucleus accumbens activation

Activity in human reward-sensitive brain areas is strongly context dependent

The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

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