Modulation of cancer cells’ radiation response in the presence of folate conjugated Au@Fe2O3 nanocomplex as a targeted radiosensitizer

Mirrahimi, Mehri; Hosseini, Vahid; Shakeri‐Zadeh, Ali; Alamzadeh, Zahra; Kamrava, Seyed Kamran; Attaran, Neda; Abed, Ziaeddin; Ghaznavi, Habib; Nami, Sanaz

doi:10.1007/s12094-018-1947-8

Cited by 17 publications

(9 citation statements)

References 44 publications

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“…It neutralizes the superoxide anion free radical, thereby reducing damage to cells by oxygen free radicals. The antioxidant capacity of body tissues can be evaluated clinically by determining SOD activity [16].…”

Section: Discussionmentioning

confidence: 99%

Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury

Shu¹,

Fang²,

Xiong³

2020

Trop. J. Pharm Res

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Purpose: To investigate the effect of penehyclidine hydrochloride (PHC) on interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), hypoxia inducible factor-1α (HIF-1α), and oxidative stress levels in lung tissues of acute lung injury (ALI) neonatal rats.Methods: 40 male Sprague-Dawley (SD) rats were assigned to model, low-dose PHC, high-dose PHC, and control groups (n = 10). Levels of IL-6, TNF-α and HIF-1α were evaluated by enzyme-linked immunosorbent assay (ELISA). Pulmonary lesions were determined histologically using H&E staining.Results: The lung tissue levels of IL-6, TNF-α and HIF-1α were significantly higher in model rats than in control rats, and significantly lower in PHC-treated rats than in model group, with decrease in levels as PHC dose increased (p < 0.05). The lung tissue activity of MPO and level of MDA in model rats were significantly higher than those in control rats, but significantly lower in the lung tissues of the two PHC groups than in the model group; decrease in levels occurred as PHC dose increased (p < 0.05).Conclusion: PHC decreases the lung and serum levels of IL-6, TNF-α and HIF-1α in a rat model of ALI, and mitigates pulmonary oxidative stress and lung tissue damage. Thus, penehyclidine hydrochloride may be useful to mitigate ALI-induced damage in patients. However, further studies and clinical trials are required to ascertain this Keywords: Penehyclidine hydrochloride, Alveolar septum, Acute lung injury, Inflammatory cells, IL-6, TNF-α, HIF-1α, Oxidative stress

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Section: Discussionmentioning

confidence: 99%

Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury

Shu¹,

Fang²,

Xiong³

2020

Trop. J. Pharm Res

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“…GNPs conjugated with targeting moieties also exhibit excellent radiosensitization effects that culminate in apoptosis induction. For example, folate-conjugated Au@Fe 2 O 3 NPs (44 nm) exhibited radiosensitization effects in KB cells by elevating the apoptosis rate [141]. EGFR antibody-decorated hollow gold nanospheres (anti-EGFR/HGNs, 55 nm) induced the downregulation of Bcl-2 and the upregulation of caspase 3, Bax, and Bad in HeLa cells under irradiation [121].…”

Section: Nanoradiosensitizers Based On Apoptosismentioning

confidence: 99%

The Rational Design and Biological Mechanisms of Nanoradiosensitizers

2020

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Radiotherapy (RT) has been widely used for cancer treatment. However, the intrinsic drawbacks of RT, such as radiotoxicity in normal tissues and tumor radioresistance, promoted the development of radiosensitizers. To date, various kinds of nanoparticles have been found to act as radiosensitizers in cancer radiotherapy. This review focuses on the current state of nanoradiosensitizers, especially the related biological mechanisms, and the key design strategies for generating nanoradiosensitizers. The regulation of oxidative stress, DNA damage, the cell cycle, autophagy and apoptosis by nanoradiosensitizers in vitro and in vivo is highlighted, which may guide the rational design of therapeutics for tumor radiosensitization.

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“…As this part of nanotechnology application is still newfound, there are not enough convincing evidences to ensure health-care authorities around the world for any mid-or long-term effects of these newborn particles on human organs. To minimize any unwanted effects, specialist's recommendation would clearly be "does enhancement" [1][2][3]. Dose enhancement of local or systematic application of nanoparticles has attracted a great deal of attention as expected.…”

Section: Introductionmentioning

confidence: 99%

Simulation and In Vitro Experimental Studies on Targeted Photothermal Therapy of Cancer using Folate-PEG-Gold Nanorods

2021

j Biomed Phys Eng

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Background: Selective targeting of malignant cells is the ultimate goal of anticancer studies around the world. There are some modalities for cancer therapy devastating tumor size and growth rate, meanwhile attacking normal cells. Utilizing appropriate ligands, like folate, allow the delivery of therapeutic molecules to cancer cells selectively. There are a variety of photosensitizers, like gold nanorods (GNRs), capable of absorbing the energy of light and converting it to heat, evidently build a photothermal procedure for cancer therapy.Objective: To develop a one-step approach for calculating the temperature distribution by solving the heat transfer equation with multiple heat sources originating from NIR laser-exposed GNRs. Material and Methods:In this experimental study, we simulated NIR laser heating process in a single cancer cell, with and without incubation with folate conjugated PEG-GNRs. This simulation was based on a real TEM image from an experiment with the same setup. An in vitro experiment based on aforesaid scenario was performed to validate the simulated model in practice.Results: According to the simplifications due to computational resource limits, the resulting outcome of simulation showed significant compatibility to the supporting experiment. Both simulation and experimental studies showed a similar trend for heating and cooling of the cells incubated with GNRs and irradiated by NIR laser (5 min, 1.8 W/cm 2 ). It was observed that temperature of the cells in microplate reached 53.6 °C when irradiated by laser. Conclusion:This new method can be of great application in developing a planning technique for treating tumors utilizing GNP-mediated thermal therapy.

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Modulation of cancer cells’ radiation response in the presence of folate conjugated Au@Fe2O3 nanocomplex as a targeted radiosensitizer

Cited by 17 publications

References 44 publications

Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury

Effect of penehyclidine hydrochloride on IL-6, TNF-α, HIF- 1α and oxidative stress in lung tissue of young rats with acute lung injury

The Rational Design and Biological Mechanisms of Nanoradiosensitizers

Simulation and In Vitro Experimental Studies on Targeted Photothermal Therapy of Cancer using Folate-PEG-Gold Nanorods

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