Modulation of Calcium Oxalate Dihydrate Growth by Selective Crystal-face Binding of Phosphorylated Osteopontin and Polyaspartate Peptide Showing Occlusion by Sectoral (Compositional) Zoning

Chien, Yung Ching; Masica, David L.; Gray, Jeffrey J.; Nguyen, Sang; Vali, Hojatollah; McKee, Marc D.

doi:10.1074/jbc.m109.021899

Cited by 64 publications

(65 citation statements)

References 80 publications

(114 reference statements)

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“…This theory is supported by the observation that antibodies do not recognize OPN bound to HA, while they are able to recognize OPN bound to plastic (Gorski et al, 1995). Moreover, the acidic peptide based on the OPN sequence, which was examined by RosettaSurface, was able to adsorb to a calcium oxalate crystal surface in multiple conformations (Chien et al, 2009).…”

Section: Opnsupporting

confidence: 53%

“…This phenomenon might be the result of conformational changes in DPP triggered by interactions with collagen. OPN also exhibits a different conformation when it is bound to HA from that of the solution state (Chien et al, 2009;Gorski et al, 1995). The function of n16 and OMM64 (which is also a putative IDP) is also modulated by interactions with -chitin.…”

Section: The Innate Specialization Of Idps In Biomineralizationmentioning

confidence: 99%

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Intrinsically Disordered Proteins in Biomineralization

Wojtas¹,

Dobryszycki²,

Ożyhar³

2012

Advanced Topics in Biomineralization

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Section: Opnsupporting

confidence: 53%

Section: The Innate Specialization Of Idps In Biomineralizationmentioning

confidence: 99%

Intrinsically Disordered Proteins in Biomineralization

Wojtas¹,

Dobryszycki²,

Ożyhar³

2012

Advanced Topics in Biomineralization

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“…128 Most of the polymer phase is returned back to the solution, although on rare occasions it may get trapped between the crystalline layers, serving as an evidence of said nature of formation. 129,130 Invoking this mechanism, even monocrystalline systems, such as the basic crystalline units of enamel, microsized apatite fibers, are accepted to be, may form through aggregation of subunits. The recent TEM studies have confirmed the existence of transient amorphous CAP phases in the developing enamel.…”

Section: Mechanism Of Formation Of Hap By Precipitationmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.

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“…Large structural ensembles of 10 5 candidate solutionand adsorbed-state structures were generated, from which the 100 lowest-energy structures from each state were chosen for further analysis. A similar polyAsp sequence from osteopontin binding to mineral has been modeled previously with this approach (Chien et al, 2009). …”

Section: Energy Calculation and Structure Prediction Of D10 Peptide Bmentioning

confidence: 99%

Enzyme Replacement Therapy Prevents Dental Defects in a Model of Hypophosphatasia

et al. 2011

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Modulation of Calcium Oxalate Dihydrate Growth by Selective Crystal-face Binding of Phosphorylated Osteopontin and Polyaspartate Peptide Showing Occlusion by Sectoral (Compositional) Zoning

Cited by 64 publications

References 80 publications

Intrinsically Disordered Proteins in Biomineralization

Intrinsically Disordered Proteins in Biomineralization

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Enzyme Replacement Therapy Prevents Dental Defects in a Model of Hypophosphatasia

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