Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

Pasceri, Vincenzo; Chang, J.Y.; Willerson, James T.; Yeh, Edward T.H.

doi:10.1161/01.cir.103.21.2531

Cited by 754 publications

(537 citation statements)

References 32 publications

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“…Simvastatin inhibits the production of MCP-1 by human ECs stimulated by C-reactive protein (CRP), interleukin-1␤ (IL-1␤), or lipopolysaccharide (LPS) in vitro (53), and both lovastatin and simvastatin decrease MCP-1 production in human peripheral monocytes (54,55). These effects are reversed with the addition of mevalonate (54).…”

Section: Statins As Antiinflammatory Drugs: Effects On Cells and Tissuesmentioning

confidence: 99%

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

Abeles

Pillinger

2006

Arthritis & Rheumatism

134

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Section: Statins As Antiinflammatory Drugs: Effects On Cells and Tissuesmentioning

confidence: 99%

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

Abeles

Pillinger

2006

Arthritis & Rheumatism

134

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“…A recent study has shown that in a general female population serum CRP levels are a strong predictor of cardiovascular events independent of traditional major risk factors (9). In in vitro studies, exogenously applied CRP has been reported to impair vascular endothelial expression of nitric oxide synthase (10,11), and to upregulate endothelial expression of chemokines and adhesion molecules (12,13). As the presence of microalbuminuria is a marker of vascular endothelial damage (14)(15)(16), it might be expected that the degree of urinary albumin excretion is enhanced by elevated circulating levels of CRP.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum C-reactive Protein Levels and Microalbuminuria: A Population-Based Cross-Sectional Study in Northern Iwate, Japan

et al. 2004

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Objective The presence of microalbuminuria is a renal marker of vascular endothelial damage, and is an independent and strong predictor of increased risk for cardiovascular mortality and morbidity. Elevated circulating C-reactive protein (CRP) levels have recently been reported to be a novel cardiovascular risk factor, and it has been suggested that this acute-phase protein impairs vascular endothelial function. The aim of the present study was to determine whether serum CRP level is a dependent or an independent risk factor of microalbuminuria in the general population.Methods Subjects of this cross-sectional study were apparently healthy individuals drawn from the general Japanese population (mean age, 62; men, 2,236; women, 4,217). Serum CRP levels were determined using a highly sensitive kit and urine albumin-creatinine ratio (UACR) was calculated using a single urine sample. Multivariate logistic regression analysis was used to determine which risk factors (ie, age, hypertension, diabetes, obesity, hypercholesterolemia, smoking, and CRP) might predict the presence of microalbuminuria.Results In addition to classical cardiovascular risk factors such as age, hypertension, diabetes and obesity, serum CRP levels are also significantly correlated with microalbuminuria in men (odds ratio=1.42, 95% CI= 1.13-1.79; p<0.01) and women (odds ratio=1.25, 95% CI=1.05-1.49; p<0.01). When subjects with diabetes were excluded from the analysis, serum CRP levels continued to be a significant predictor for microalbuminuria (odds ratio=1.35, 95% CI=1.06-1.73; p<0.05 for men: odds ratio=1.23, 95% CI=1.03-1.47; p<0.05 for women). ConclusionsThe present study has shown that lowgrade inflammation as represented by high sensitivity CRP levels may be significantly related to the presence of microalbuminuria. This suggests that microalbuminuria may be a useful marker representing systemic low-grade inflammation as well as being an established cardiovascular risk factor in apparently healthy individuals.

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“…[8] MCP-1 facilitate monocyte chemotactic into the arterial wall. [8,66] MCP-1 is a kind of chemokines produced by ECs as a response to CRP, [111] MCSF, [68] and oxidized lipoprotein, and the other stimulus. [112,113] The disturbances in local blood flow may result in some physiologic changes, which are responsible for predilection lesion of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Periodontitis - Induced Atherosclerosis

Hudyono

Sunariani

2010

IJTID

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Nowadays CVD become the most common cause of death in US and worldwide. Atherosclerosis plays an important role in CVDs pathogenesis. Atherosclerosis decreases the elasticity of the vascular. Atherosclerosis shares the same risk factor as CVD, in which obesity, hyperlipidemia, hypertension and lack of physical activity may initiate it. However, 50% of all CVD patients are lack of the usual causes of CVD. The purpose of this review is to reveal the mechanism of periodontitis-induced atherosclerosis. Inflammation and autoimmune disease might play an important role in initiate the CVD. Periodontitis is one of the oral diseases which can cause systemic inflammation and may induce the atherosclerosis. Porphyromonas gingivalis (Pg) which is the major cause of periodontitis can induce it by expressing protein gp130 in its fimbriae

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Modulation of C-Reactive Protein–Mediated Monocyte Chemoattractant Protein-1 Induction in Human Endothelial Cells by Anti-Atherosclerosis Drugs

Abstract: These results further strengthen the role of CRP in the pathogenesis of vascular inflammation and, likely, atherosclerosis and provide a crucial insight into a novel mechanism of action of anti-atherosclerosis drugs such as simvastatin and fenofibrate.

Cited by 754 publications

References 32 publications

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

Statins as antiinflammatory and immunomodulatory agents: A future in rheumatologic therapy?

Association between Serum C-reactive Protein Levels and Microalbuminuria: A Population-Based Cross-Sectional Study in Northern Iwate, Japan

Mechanisms of Periodontitis - Induced Atherosclerosis

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