Modulation of brain networks during MR-compatible transcranial direct current stimulation

Leaver, Amber M.; Gonzalez, Sara; Vasavada, Megha; Kubicki, Antoni; Jog, Mayank; Wang, Danny J.J.; Woods, Roger P.; Espinoza, Randall; Gollan, Jackie K.; Parrish, Todd B.; Narr, Katherine L.

doi:10.1016/j.neuroimage.2022.118874

Cited by 14 publications

(17 citation statements)

References 77 publications

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“…Analysis of resting-state functional magnetic resonance imaging (rs-fMRI) data provided evidence that an increase in functional connectivity (FC) can be induced by tDCS in some DOCs patients, both at the site of stimulation and in remote regions (Peng et al 2022). Similar findings have been reported in patients with neurological disorders, such as schizophrenia or primary progressive aphasia (Chan and Han 2020), and in healthy humans, with FC strengthening observed between frontal and parietal, temporal and parieto-occipital regions (Keeser et al 2011;Peña-Gómez et al 2012;Mondino et al 2019;Leaver et al 2022;Bouchard, Renauld, and Fecteau 2023).…”

Section: Introductionsupporting

confidence: 86%

Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

Hoffner,

Castro,

Uhrig

et al. 2024

Preprint

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Background: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation approach that has been reported to perturb task activity and to benefit patients with a variety of diseases. Nevertheless, the effects of tDCS on brain dynamics and transitions in brain patterns across states of consciousness remain poorly understood. Objective: Here, we investigated the modulatory effect of prefrontal cortex (PFC) tDCS on brain dynamics, both in the awake state and during anesthesia-induced loss of consciousness in non-human primates. Methods: We acquired functional magnetic resonance imaging (fMRI) data before, during, and after the application of high-density tDCS (HD-tDCS) utilizing a prefrontal-occipital montage with two electrodes. In the awake state, macaques received either anodal or cathodal PFC stimulation. Under anesthesia, macaques underwent two consecutive anodal PFC stimulations of increasing intensity. Dynamical functional connectivity was measured using fMRI, and the resulting connectivity matrices were clustered into distinct brain patterns. Results: We found that cathodal PFC HD-tDCS robustly disrupted the rich dynamic repertoire of brain patterns of the awake state. It increased the brain structure-function correlation, decreased Shannon entropy, and strongly favored Markov chain transition probabilities towards patterns closest to anatomy. Under anesthesia, 2 mA anodal PFC HD-tDCS significantly changed the distribution of brain patterns and reduced the structure-function correlation. Conclusion: Our findings offer compelling evidence that prefrontal tDCS induces a striking modification in the fMRI-based dynamic organization of the brain across varying states of consciousness. This contributes to an enhanced understanding of the neural mechanisms underlying tDCS neuromodulation.

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Section: Introductionsupporting

confidence: 86%

Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

Hoffner,

Castro,

Uhrig

et al. 2024

Preprint

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“…[11][12][13][14] Transcranial direct current stimulation (tDCS) is a safe, noninvasive, and painless treatment technique. [15][16][17][18] It applies low-intensity direct current using scalp electrodes overlying targeted cerebral cortical areas through the scalp. [15][16][17] Although a variety of studies have reported tDCS for anxiety and depression relief, [19][20][21][22][23][24][25] there are still insufficient data to investigate the efficacy of tDCS in the treatment of anxiety and depression in patients with OC during PPP.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18] It applies low-intensity direct current using scalp electrodes overlying targeted cerebral cortical areas through the scalp. [15][16][17] Although a variety of studies have reported tDCS for anxiety and depression relief, [19][20][21][22][23][24][25] there are still insufficient data to investigate the efficacy of tDCS in the treatment of anxiety and depression in patients with OC during PPP. Therefore, this retrospective study explored the efficacy of tDCS for anxiety and depression in patients with OC during PPP.…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation in the treatment of anxiety and depression in patients with oral cancer during perioperative period

et al. 2022

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This study retrospectively investigated the efficacy of transcranial direct current stimulation (tDCS) in the treatment of anxiety and depression in patients with oral cancer (OC) during the perioperative period (PPP). This retrospective study reviewed the electronic medical records of patients who underwent OC surgery and experienced anxiety and depression during PPP. The patients were divided into the treatment (n = 36) and control (n = 36) groups. The patients in the treatment group received tDCS, whereas those in the control group did not receive tDCS. The primary outcomes included the Self-rating Anxiety Scale (SAS) and the Self-rating Depression Scale (SDS). Secondary outcomes included adverse events (AEs). We analyzed the outcome data before and after treatment. After treatment, patients in the treatment group achieved greater relief in SAS (P < .01) and SDS (P < .01) scores than those in the control group. Regarding safety, no electronic medical records reported any AEs in this study. The results of this study showed that tDCS may help relieve depression and anxiety in patients with OC during PPP. However, high-quality prospective randomized controlled trials are required to confirm these findings.

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“…Our results showed significant association only at the network-level. It revealed (1) the importance of network-level changes during stimulation, (2) reflecting the diffuse stimulation applied relative to the size of tDCS electrodes, and (3) might be related to this fact that the neurobiological effects of tDCS is less straightforward at the voxels/regions/clusters level [35]. Over the past several years there has been a strong movement toward network-based effects of brain stimulation technologies [36] and our results suggest that tDCS effects may tend to spread across the networks.…”

Section: Discussionmentioning

confidence: 99%

“…(1) Our findings showed significant associations only at the network-level. It might be related to this fact that the neurobiological effects of tDCS is less straightforward at the voxels/regions/clusters level [34] and emphesizes the importance of network-level changes during stimulation. Over the past several years there has been a strong movement toward network-based effects of brain stimulation technologies [35] and our results suggest that tDCS effects may tend to spread across the networks not a restricted local brain region.…”

Section: Discussionmentioning

confidence: 99%

Dose-Response in Modulating Brain Function with Transcranial Direct Current Stimulation: From Local to Network Levels

Soleimani

Kuplicki

Paulus

et al. 2022

Preprint

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Background: Non-invasive brain stimulation methods for modulating brain activity via transcranial technologies like transcranial direct current stimulation (tDCS) are increasingly prevalent to investigate the relationship between modulated brain regions and stimulation outcomes. However, the inter-individual variability of tDCS has made it challenging to detect intervention effects at the group level. Collecting multiple modalities of magnetic resonance imaging data (i.e., structural and functional MRI) helps to investigate how dose-response ultimately shapes brain function in response to tDCS. Method: We collected data in a randomized, triple-blind, sham-controlled trial with two parallel arms. Sixty participants with MUD were randomly assigned to sham or active tDCS (n=30 per group, 2 mA, 20 minutes, anode/cathode over F4/Fp1). Structural and functional MRI (including high-resolution T1 and T2-weighted MRI, resting-state fMRI, and methamphetamine cue-reactivity task with meth versus neutral cues) were collected immediately before and after tDCS. T1 and T2-weighted MRI data were used to generate head models for each individual to simulate electric fields. Associations between electric fields (dose) and changes in brain function (response) were investigated at four different levels: (1) voxel level, (2) regional level (atlas-based parcellation), (3) cluster level (active clusters in the contrast of interest), and (4) network level (both task-based and resting-state networks). Result: At the (1) voxel-level, (2) regional level, and (3) cluster level, our results showed no significant correlation between changes in the functional activity and electric fields. However, (4) at the network level, a significant negative correlation was found between the electric field and ReHo in the default mode network (r=-0.46 (medium effect size), p corrected=0.018). For the network-level analysis of task-based fMRI data, frontoparietal connectivity showed a positive significant correlation with the electric field in the frontal stimulation site (r=0.41 (medium effect size), p corrected=0.03). Conclusion: The proposed pipeline provides a methodological framework to analyze tDCS effects in terms of dose-response relationships at four different levels to directly link the electric field (dose) variability to the variability of the neural response to tDCS. The results suggest that network-based analysis might be a better approach to provide novel insights into the dependency of the neuromodulatory effects of tDCS on the regional current dose in each individual. Dose-response integration can be informative for dose optimization/customization or predictive/treatment-response biomarker extraction in future brain stimulation studies.

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Modulation of brain networks during MR-compatible transcranial direct current stimulation

Cited by 14 publications

References 77 publications

Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.

Transcranial direct current stimulation in the treatment of anxiety and depression in patients with oral cancer during perioperative period

Dose-Response in Modulating Brain Function with Transcranial Direct Current Stimulation: From Local to Network Levels

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