Modulation of brain lipids of rats by various dietary oils: Sunflower, high-oleic sunflower, olive, rapeseed or coriander oil

Weber, Nikolaus; Kiewitt, Irmgard; Mukherjee, Kumar D.

doi:10.1016/s0271-5317(99)00060-3

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…Therefore, the altered pituitary sensitivity observed in the present study might be the result of a modification of the phospholipid composition of the pituitary gland induced by the dietary fat profile. This notion is supported by a recent study that shows specific dietary fat types are assimilated into the PE and PC phospholipids of rat brains (Weber et al, 1999). Further, the same study also showed that the feeding of specific fat types modulates the proportion of DHA (22:6n-3) and AA (20:4n-6) that are assimilated into the PE and PC phospholipids.…”

Section: Discussionsupporting

confidence: 62%

Dietaryn-3 andn-6 Fatty Acids Alter Avian Pituitary Sensitivity

Newman

Storlien

Bryden

et al. 2003

Nutritional Neuroscience

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The effects of dietary saturated and polyunsaturated fatty acids (PUFAs) of the n-3 and n-6 series on avian pituitary sensitivity were investigated by infusing human growth hormone (GH) releasing hormone--fragment 1-29--and chicken luteinising hormone releasing hormone (LHRH) into catheterized broiler chickens. At 3 weeks of age three groups (n = 18; six birds per group) were fed for 6 weeks isonitrogenous and isoenergetic experimental diets containing 80 g/kg of edible tallow (saturated fatty acids), fish oil (n-3 PUFAs) or sunflower oil (n-6 PUFAs). Jugular catheterisation was performed under general anaesthesia during week four of the dietary treatments and the birds allowed 7 days post surgery to recover. A bolus of LHRH (20 microg/bird) and a GH releasing hormone (12.5 microg/kg) infusion was given on different days to each chicken and serial blood samples taken over a 1 h period. Plasma luteinising hormone and GH concentrations were measured by radioimmunoassay. Pre-infusion GH concentrations were similar for the tallow, fish and sunflower oil dietary groups (5.2 +/- 3.9, 5.2 +/- 1.0 and 6.1 +/- 3.1 ng/ml, respectively), however, GH concentration in response to the GH releasing hormone infusion was elevated in the sunflower oil group (44.7 +/- 5.7 ng/ml) when compared to chicken fed tallow (33.7 +/- 9.7ng/ml) or fish oil (21.3 +/- 5.0 ng/ml). There was a significant decrease (P < 0.05) in the clearance rate of plasma GH for the birds fed the fish oil compared with those fed sunflower oil with an intermediate value being observed in the tallow fed group. Pre-infusion plasma luteinising hormone concentrations for the birds fed tallow (3.2 +/- 0.7 ng/ml) were significantly elevated (P < 0.05) when compared to birds fed either the sunflower oil (0.84 +/- 0.25 ng.ml) or fish oil (0.93 +/- 0.22 ng/ml) diets. There were no significant differences between the dietary groups in either the maximal plasma luteinising concentration or its disappearance rate following the LHRH infusion. The data demonstrate that dietary fatty acids alter avian pituitary sensitivity and this modulation is determined by the nature of the dietary fat rather than the degree of saturation per se. In addition, this study also shows that dietary fats have a differential effect on pituitary cell activity and are specific to certain pituitary cell types.

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Section: Discussionsupporting

confidence: 62%

Dietaryn-3 andn-6 Fatty Acids Alter Avian Pituitary Sensitivity

Newman

Storlien

Bryden

et al. 2003

Nutritional Neuroscience

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“…The decrease in the level of arachidonic acid is envisaged to be caused by the presence of petroselinic acid having a Δ 6 ‐double bond that inhibits the Δ 6 ‐desaturase as a pseudo‐product by mimicking the structure of 18:3 n ‐6, a precursor of arachidonic acid (Weber et al . ). CO might be useful for modulating the amounts of arachidonate in the cerebral membranes in specific conditions of health and disease.…”

Section: Discussionmentioning

confidence: 97%

“…Petroselinic acid from triacylglycerols of C. sativum is incorporated extensively into the lipids of heart and liver of rats and, concomitantly, the level of arachidonic acid in these tissues was reduced (Weber et al 1997). The decrease in the level of arachidonic acid is envisaged to be caused by the presence of petroselinic acid having a Δ 6 -double bond that inhibits the Δ 6 -desaturase as a pseudo-product by mimicking the structure of 18:3n-6, a precursor of arachidonic acid (Weber et al 1999). CO might be useful for modulating the amounts of arachidonate in the cerebral membranes in specific conditions of health and disease.…”

Section: Discussionmentioning

confidence: 99%

Potential Protective Effect of Cold-Pressed C oriandrum Sativum Oil Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

El-Hadary

Ramadan

2015

Journal of Food Biochemistry

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The protective effect of cold-pressed coriander (Coriandrum sativum) oil (CO) against the toxicity caused by carbon tetrachloride (CCl4) in rats was studied. CO is characterized by its high levels of monounsaturated fatty acids and polyunsaturated fatty acids, tocopherols and phenolic compounds. Male Wistar rats were orally treated with two doses of CO (100 and 200 mg/kg) with administration of CCl4 (1 mL/kg, CCl4 in olive oil) for 8 weeks. Liver biochemical parameters were determined in animals treated with CO. The results clearly demonstrated that CO augments the antioxidants' defense mechanism against CCl4-induced toxicity and provides evidence that CO may have a therapeutic role in free radical-mediated diseases. Treatment with CO significantly reduced the impact of CCl4 toxicity on aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, kidney function indicators, protein profile, lipid profile and antioxidant markers of CCl4-induced liver injury rats. The overall potential of the antioxidant system was significantly enhanced by the CO supplements as the hepatic malondialdehyde levels were lowered, whereas reduced glutathione levels were elevated. The hepatoprotective impact of CO was also supported by histopathological studies of liver tissue. Histopathological examination showed that CO reduced fatty degeneration, cytoplasmic vacuolization and necrosis in CCl4-treated rats. The results indicate the potentiality of CO to act as natural antioxidant by preventing the peroxidative damage caused by CCl4. PRACTICAL APPLICATIONSBiologically active natural compounds are of interest for pharmaceutical industry in the prevention of different diseases caused by lipid peroxidative damage (i.e., ischemia, coronary atherosclerosis, Alzheimer's disease and carcinogenesis). In the present study, the capability of cold-pressed Coriandrum sativum oil (CO) to protect against CCl4-induced hepatotoxicity was investigated. The study suggested that CO has potent hepatoprotective activity in CCl4-induced liver injury in rats. CO possesses antioxidant potential and inhibits the deleterious effect of free radicals generated by CCl4. CO is rich in tocols, phenolic compounds and other bioactive constituents, which might be responsible for the protective effects. These observations provide biochemical data supporting the potential clinical use of CO in the treatment of some hepatic disorders. The results suggest that the ability of CO to ameliorate CCl4-induced liver injury is associated with its antioxidant and radical-scavenging characteristics.

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“…Coriander seed oil, which contained about 70% petroselinic acid, showed a significant hypolipidomic effect on animals [6]. High petroselinic acid diets found to lower the n-6 long-chain fatty acids of the phospholipids [7]. Hence, petroselinic has become more and more important in industry and human health.…”

Section: Introductionmentioning

confidence: 99%

Free Energy Contribution to Gas Chromatographic Separation of Petroselinate and Oleate Esters

Sansa-ard

Aryusuk

Lilitchan

et al. 2011

Chromatography Research International

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The ease of separation by gas chromatography between petroselinic and oleic acids depends on the alcohol moieties of their esters. The esters of higher molecular weight alcohols tend to be better separated on a 90%-biscyanopropyl-10%-cyanopropylphenyl polysiloxane capillary column (30 m × 0.25 mm i.d.). By analysis of free energies contribution from different parts of the molecules, it is tentatively concluded that the interaction between the double bond and the column stationary phase is interfered by the bulky alkyl group, and it is the major driving force for the separation of the two fatty acids.

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Modulation of brain lipids of rats by various dietary oils: Sunflower, high-oleic sunflower, olive, rapeseed or coriander oil

Cited by 14 publications

References 24 publications

Dietaryn-3 andn-6 Fatty Acids Alter Avian Pituitary Sensitivity

Dietaryn-3 andn-6 Fatty Acids Alter Avian Pituitary Sensitivity

Potential Protective Effect of Cold-Pressed C oriandrum Sativum Oil Against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Free Energy Contribution to Gas Chromatographic Separation of Petroselinate and Oleate Esters

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