Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model

Bousquet, M.; Gibrat, Claire; Saint-Pierre, Martine; Julien, Carl; Calon, Frédéric; Cicchetti, Francesca

doi:10.1016/j.pnpbp.2009.07.018

Cited by 94 publications

(42 citation statements)

References 57 publications

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“…For example, -3 PUFAs and their metabolites have been shown to upregulate the expression of the Bcl-2 family of anti-apoptotic proteins but downregulate the apoptotic proteases caspase-3 and -9 and pro-apoptotic signaling proteins in a number of cell types, including neurons (Lukiw et al, 2005;Bazan, 2009). It has also been suggested that -3 PUFAs enhance expression of neurotrophins, including brain-derived neurotrophic factor, which can have both neuroprotective and pro-regenerative effects (Bousquet et al, 2009). It is important to note the observations made in a model of sciatic nerve crush in rat, in which the presence of RXR and retinoic acid receptor RAR was shown in regenerating nerves, in particular at 7 d after injury (Zhelyaznik and Mey, 2006), indicating that these receptors may have an important role in the regenerative response.…”

Section: Discussionmentioning

confidence: 99%

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Gladman¹,

Huang²,

Lim³

et al. 2012

J. Neurosci.

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Functional recovery after a peripheral nerve injury (PNI) is often poor. There is a need for therapies that protect neurons against injury and enhance regeneration. Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to have therapeutic potential in a variety of neurological disorders, including acute traumatic injury. The objective of this study was to assess the neuroprotective and proregenerative potential of -3 PUFAs in PNI. We investigated this in mice that express the fat-1 gene encoding for -3 fatty acid desaturase, which leads to an increase in endogenous -3 PUFAs and a concomitant decrease in -6 PUFAs. Dorsal root ganglion (DRG) neurons from wild-type or fat-1 mice were subjected to a mechanical strain or hypoxic injury, and cell death was assessed using ethidium homodimer-1 labeling. The fat-1 background appears to confer robust neuroprotection against both injuries. We then examined the early functional and morphological changes in wild-type and fat-1 mice after a sciatic nerve crush. An accelerated functional recovery 7 d after injury was seen in fat-1 mice when assessed using von Frey filaments and the sciatic nerve functional index. These observations were also mapped to changes in injury-related markers. The injury-induced expression of ATF-3 was decreased in the DRG of fat-1 mice, whereas the axons detected 6 mm distal to the crush were increased. Fat-1 animals also had some protection against muscle atrophy after injury. In conclusion, both in vitro and in vivo experiments support the idea that a higher endogenous -3 PUFA could lead to beneficial effects after a PNI.

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Section: Discussionmentioning

confidence: 99%

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Gladman¹,

Huang²,

Lim³

et al. 2012

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…However, there may exist other mechanisms by which endogenous -3 PUFAs protect ischemia-injured neurons. For example, -3 PUFAs and their metabolites prevent cell apoptosis by upregulating the expression of the Bcl-2 family of anti-apoptotic proteins ( 34,64 ) and -3 PUFAs enhance expression of neurotrophins, including brain-derived neurotrophic factor ( 65 ). Whether these mechanisms are involved in neuronal protection of fat-1 mice against global ischemia injury needs to be explored in the future.…”

Section: Attenuated Microglia Activation and Astrocytes Reaction In Tmentioning

confidence: 99%

Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury

Luo

Ren

Wan

et al. 2014

Journal of Lipid Research

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“…Anti-apoptotic ( 35,42 ), anti-oxidant ( 35,43,44 ), and anti-infl ammatory ( 45-47 ) effects of n -3 PUFAs have been discussed. In addition, n -3 PUFAs stand as natural potential modulators of neurotrophic factors such as BDNF ( 5,43,48 ). With respect to the potential anti-apoptotic properties of n -3 PUFAs, a protein microarray analysis conducted in Fat-1 mice revealed a pattern of expression involved in the enhancement of neuronal survival and function associated with increased hippocampal expression of nitric oxide synthase, the tumor suppressor phosphatase and tensin homolog, and mitogen-activated protein kinase-2 (MAPK-2) ( 49 ).…”

Section: Downloaded Frommentioning

confidence: 99%

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

Bousquet

Gue

Émond

et al. 2011

Journal of Lipid Research

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Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model

Cited by 94 publications

References 57 publications

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Improved Outcome after Peripheral Nerve Injury in Mice with Increased Levels of Endogenous Omega-3 Polyunsaturated Fatty Acids

Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury

Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

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