Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses

Xu, Shouping; Sui, Shiyao; Zhang, Xianyu; Pang, Boran; Wan, Lin; Pang, Da

doi:10.1002/med.21571

Cited by 7 publications

(2 citation statements)

References 353 publications

(441 reference statements)

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“…The emerging link between the Hippo pathway and autophagy is now largely implicated in pathophysiological processes, such as cancer, metabolic and neurodegenerative diseases, and cardiovascular diseases (Fig. 5) [101][102][103] . Here we introduce some small molecules or drugs that target the Hippo core components autophagy regulatory network (Table 2).…”

Section: Hippo-yap-autophagy Axis In Clinical Applicationsmentioning

confidence: 99%

Emerging role of the Hippo pathway in autophagy

Wang

Huang

et al. 2020

Cell Death Dis

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Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant biological properties in controlling organ size, tissue homeostasis, and regeneration. Recently, the Hippo-YAP axis has been extensively referred to as the pathophysiological processes regulating autophagy. Understanding the cellular and molecular basis of these processes is crucial for identifying disease pathogenesis and novel therapeutic targets. Here we review recent findings from Drosophila models to organisms. We particularly emphasize the regulation between Hippo core components and autophagy, which is involved in normal cellular regulation and the pathogenesis of human diseases, and its application to disease treatment.

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Section: Hippo-yap-autophagy Axis In Clinical Applicationsmentioning

confidence: 99%

Emerging role of the Hippo pathway in autophagy

Wang

Huang

et al. 2020

Cell Death Dis

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“…Several mechanisms have been proposed for mTOR inhibition-mediated dyslipidemia, including reduced lipoprotein catabolism containing apoB100 ( 135 ), impaired bile acid synthesis ( 136 ), and inhibition of lipoprotein lipase activity following upregulation of apolipoprotein CIII ( 137 ). Statins not only lower lipids but also induce autophagy by activating AMPK and/or inhibiting Rac1 mTOR signaling ( 138 ). Linking the two may therefore help to enhance mTOR inhibitor-induced autophagy and maintain normal lipid levels and improve plaque stability.…”

Section: Pharmacological Modulation Of Autophagymentioning

confidence: 99%

The Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis

Hua

Zhang²,

Liu³

et al. 2022

Front. Cardiovasc. Med.

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Increasing attention is now being paid to the important role played by autophagic flux in maintaining normal blood vessel walls. Endothelial cell dysfunction initiates the development of atherosclerosis. In the endothelium, a variety of critical triggers ranging from shear stress to circulating blood lipids promote autophagy. Furthermore, emerging evidence links autophagy to a range of important physiological functions such as redox homeostasis, lipid metabolism, and the secretion of vasomodulatory substances that determine the life and death of endothelial cells. Thus, the promotion of autophagy in endothelial cells may have the potential for treating atherosclerosis. This paper reviews the role of endothelial cells in the pathogenesis of atherosclerosis and explores the molecular mechanisms involved in atherosclerosis development.

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