Modulation of auditory percepts by transcutaneous electrical stimulation

Ueberfuhr, Margarete A.; Braun, Amalia; Wiegrebe, Lutz; Grothe, Benedikt; Drexl, Markus

doi:10.1016/j.heares.2017.03.008

Cited by 9 publications

(4 citation statements)

References 60 publications

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“…[16,21]). A contribution from generic (speech-unspecific) central auditory processes is supported by (1) the fact that our two-talker results closely resemble results from a matching TACS study with non-speech sounds [42], (2) findings from other non-speech-entrainment studies [43], and (3) no evidence for TACS effects on peripheral auditory processing [44]. This notion may be tested in the future by combining envTCS with simultaneous neuroimaging or electrophysiology [45] and directly comparing envTCS-induced neural response modulations for speech stimuli versus nonspeech equivalents [46].…”

Section: Which Processes Underlie the Observed Envtcs Effects On Speech-recognition Performance?supporting

confidence: 59%

Neural Entrainment to Speech Modulates Speech Intelligibility

et al. 2018

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Speech is crucial for communication in everyday life. Speech-brain entrainment, the alignment of neural activity to the slow temporal fluctuations (envelope) of acoustic speech input, is a ubiquitous element of current theories of speech processing. Associations between speech-brain entrainment and acoustic speech signal, listening task, and speech intelligibility have been observed repeatedly. However, a methodological bottleneck has prevented so far clarifying whether speech-brain entrainment contributes functionally to (i.e., causes) speech intelligibility or is merely an epiphenomenon of it. To address this long-standing issue, we experimentally manipulated speech-brain entrainment without concomitant acoustic and task-related variations, using a brain stimulation approach that enables modulating listeners' neural activity with transcranial currents carrying speech-envelope information. Results from two experiments involving a cocktail-party-like scenario and a listening situation devoid of aural speech-amplitude envelope input reveal consistent effects on listeners' speech-recognition performance, demonstrating a causal role of speech-brain entrainment in speech intelligibility. Our findings imply that speech-brain entrainment is critical for auditory speech comprehension and suggest that transcranial stimulation with speech-envelope-shaped currents can be utilized to modulate speech comprehension in impaired listening conditions.

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Section: Which Processes Underlie the Observed Envtcs Effects On Speech-recognition Performance?supporting

confidence: 59%

Neural Entrainment to Speech Modulates Speech Intelligibility

et al. 2018

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“…On the other hand, it is possible that our hypothesis that TACS at conventional intensities alters OHC function is false. We think this latter interpretation is more plausible, because it agrees with recent results showing no effect of galvanic vestibular stimulation on DPOAE [8,9]. It remains to be investigated whether auditory effects of TACS originate at a different auditory processing stage than OHCs, for example, the auditory nerve, brainstem, or cerebral cortex (see Supplementary Material S3).…”

supporting

confidence: 87%

No evidence for modulation of outer hair-cell function by 4-Hz transcranial alternating current stimulation

Bree

Formisano²,

Barneveld³

et al. 2019

Brain Stimulation

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“…However, we did not observe such enhancement in the contralateral V1 & V2 and thalamus, indicating differences in hemispheric modulatory effects by the vestibular system on sensory processing. Proposed multisensory processing mechanisms rely on hemispheric dominance or lateralization of vestibular functions (38, 55, 57–59). In particular, the activity dominance shown in our study shifted to the hemisphere ipsilateral to the stimulated vestibular labyrinth and VN.…”

Section: Discussionmentioning

confidence: 99%

Optogenetic fMRI interrogation of brain-wide central vestibular pathways

Leong

Chan

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Blood oxygen level-dependent functional MRI (fMRI) constitutes a powerful neuroimaging technology to map brain-wide functions in response to specific sensory or cognitive tasks. However, fMRI mapping of the vestibular system, which is pivotal for our sense of balance, poses significant challenges. Physical constraints limit a subject’s ability to perform motion- and balance-related tasks inside the scanner, and current stimulation techniques within the scanner are nonspecific to delineate complex vestibular nucleus (VN) pathways. Using fMRI, we examined brain-wide neural activity patterns elicited by optogenetically stimulating excitatory neurons of a major vestibular nucleus, the ipsilateral medial VN (MVN). We demonstrated robust optogenetically evoked fMRI activations bilaterally at sensorimotor cortices and their associated thalamic nuclei (auditory, visual, somatosensory, and motor), high-order cortices (cingulate, retrosplenial, temporal association, and parietal), and hippocampal formations (dentate gyrus, entorhinal cortex, and subiculum). We then examined the modulatory effects of the vestibular system on sensory processing using auditory and visual stimulation in combination with optogenetic excitation of the MVN. We found enhanced responses to sound in the auditory cortex, thalamus, and inferior colliculus ipsilateral to the stimulated MVN. In the visual pathway, we observed enhanced responses to visual stimuli in the ipsilateral visual cortex, thalamus, and contralateral superior colliculus. Taken together, our imaging findings reveal multiple brain-wide central vestibular pathways. We demonstrate large-scale modulatory effects of the vestibular system on sensory processing.

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Modulation of auditory percepts by transcutaneous electrical stimulation

Cited by 9 publications

References 60 publications

Neural Entrainment to Speech Modulates Speech Intelligibility

Neural Entrainment to Speech Modulates Speech Intelligibility

No evidence for modulation of outer hair-cell function by 4-Hz transcranial alternating current stimulation

Optogenetic fMRI interrogation of brain-wide central vestibular pathways

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