Modulation of attention functions by anodal tDCS on right PPC

Roy, Lal Bahadur; Sparing, Roland; Fink, Gereon R.; Hesse, Maike D.

doi:10.1016/j.neuropsychologia.2015.02.028

Cited by 90 publications

(62 citation statements)

References 119 publications

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“…Recently, an enhancement of cortical-evoked potentials after prefrontal PAS25 was demonstrated via TMS-EEG 88 . Since cognitive functions that are affected by nicotine abstinence, such as working memory, episodic memory and attention 20 are related to the prefrontal cortex 89–92 and can also be modulated by non-invasive brain stimulation protocols 93, 94 as well as nicotinic agents 1–3 , it would be relevant and feasible to focus the future exploration of nicotine withdrawal-related plasticity shifts directly on prefrontal cortex physiology.…”

Section: Discussionmentioning

confidence: 99%

Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic α4β2-receptor partial agonist varenicline

Batsikadze

Paulus

Hasan

et al. 2017

Sci Rep

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Nicotine modulates neuroplasticity and improves cognitive functions in animals and humans. In the brain of smoking individuals, calcium-dependent plasticity induced by non-invasive brain stimulation methods such as transcranial direct current stimulation (tDCS) and paired associative stimulation (PAS) is impaired by nicotine withdrawal, but partially re-established after nicotine re-administration. In order to investigate the underlying mechanism further, we tested the impact of the α4β2-nicotinic receptor partial agonist varenicline on focal and non-focal plasticity in smokers during nicotine withdrawal, induced by PAS and tDCS, respectively. We administered low (0.3 mg) and high (1.0 mg) single doses of varenicline or placebo medication before stimulation over the left motor cortex of 20 healthy smokers under nicotine withdrawal. Motor cortex excitability was monitored by single-pulse transcranial magnetic stimulation-induced motor evoked potential amplitudes for 36 hours after plasticity induction. Stimulation-induced plasticity was absent under placebo medication, whereas it was present in all conditions under high dose. Low dose restituted only tDCS-induced non-focal plasticity, producing no significant impact on focal plasticity. High dose varenicline also prolonged inhibitory plasticity. These results are comparable to the impact of nicotine on withdrawal-related impaired plasticity in smokers and suggest that α4β2 nicotinic receptors are relevantly involved in plasticity deficits and restitution in smokers.

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Section: Discussionmentioning

confidence: 99%

Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic α4β2-receptor partial agonist varenicline

Batsikadze

Paulus

Hasan

et al. 2017

Sci Rep

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“…In fact, these different outcomes very much underpin our earlier points in terms of the need of establishing tES protocols, not only for duration and stimulation strength but also regarding baseline task performance, polarity, size of the stimulation field, pre-activation dependant and inter-individual effects (see also Shin et al (2015), Roy et al (2015). Moreover, related to this last point, unlike for TMS, there is no calibration of stimulation intensity in tES.…”

Section: Uncovering Spatial Attention With Tes Tdcs and Arousal With mentioning

confidence: 94%

“…We hope that the following studies justify our optimism. Roy et al (2015) investigated the effects of tDCS on a version of the attention network test (ANT, Fan et al, 2002) assessing its influence on alerting and spatial re-orienting as well as executive function. Over 4 different days they applied 1.5 mA anodal TDCS for 20 min (active and sham) over left dorso-lateral (EEG F3), left parietal (EEG P3) and right parietal (EEG P4) sites.…”

Section: Uncovering Spatial Attention With Tes Tdcs and Arousal With mentioning

confidence: 99%

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Harvey

Kerkhoff

2015

Neuropsychologia

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“…A more recent study in which both hemispheres received opposite polarity stimulation did not identify any significant effect on performance (Li et al 2015a). Using a more comprehensive version of Posner's paradigm that also measures alerting and executive attention-the attention network test (Fan et al 2002)-Roy et al (2015 found that anodal tDCS to the right parietal cortex decreased performance after invalid exogenous cues. Stimulation over the right inferior frontal cortex did not seem to affect orienting in the attention network test , although here, participants did not perform the test until 1.5 h after stimulation offset.…”

Section: Endogenous and Exogenous Orientingmentioning

confidence: 99%

Transcranial Electrical Stimulation as a Tool to Enhance Attention

et al. 2017

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Attention is a fundamental cognitive process-without it, we would be helplessly adrift in an overload of sensory input. There is considerable interest in techniques that can be used to enhance attention, including transcranial electrical stimulation (tES). We present an overview of 52 studies that have paired attention tasks with tES, mostly in the form of transcranial direct current stimulation (tDCS). In particular, we discuss four aspects of attention that have been most extensively targeted to date: visual search, spatial orienting (e.g., Posner cueing tasks), spatial bias (e.g., line bisection tasks), and sustained attention. Some promising results have been reported in each of these domains. However, drawing general conclusions about the efficacy of tES is at present hampered by a large diversity in study design and inconsistent findings. We highlight some pitfalls and opportunities and suggest how these may be addressed in future research aiming to use tES as a tool to enhance or test theoretical hypotheses about attention.

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Modulation of attention functions by anodal tDCS on right PPC

Cited by 90 publications

References 119 publications

Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic α4β2-receptor partial agonist varenicline

Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic α4β2-receptor partial agonist varenicline

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Transcranial Electrical Stimulation as a Tool to Enhance Attention

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