Modulation of Arterial Intima Stiffness by Disturbed Blood Flow
Briana C. Bywaters,
Andreea Trache,
Gonzalo M. Rivera
Abstract:BackgroundThe intima, comprising the endothelium and the subendothelial matrix, plays a crucial role in the development of atherosclerotic plaques, especially in bifurcations and curved segments of arteries. The mechanical stress arising from disturbed blood flow (d-flow) and the stiffening of the arterial wall contributes to endothelial dysfunction. However, the specific impacts of these physical forces on the mechanical environment of the intima remain undetermined. To address this gap in knowledge, we inves… Show more
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