Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer

Scott, Jessica M.; Khakoo, Aarif Y.; Mackey, John R.; Haykowsky, Mark J.; Douglas, Pamela S.; Jones, Lee W.

doi:10.1161/circulationaha.111.021774

Cited by 166 publications

(132 citation statements)

References 91 publications

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“…It is well-established that Anth-C directly injures the myocardium [22], which induces structural changes that can perturb myocardial contractile function beyond that commonly seen with aging [23]. In the present study, Ees was normal at rest; however, the typical exercise-induced increase was attenuated at moderate intensities (i.e., 50% and 75% In the present study, as exercise intensity increased from rest to 75% W max , control subjects reduced Ea/Ees by 42%, similar to the findings from previous studies of healthy individuals (aged 40-70 years) [24,25].…”

Section: Discussionmentioning

confidence: 99%

Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

et al. 2016

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Background. Anthracycline-containing chemotherapy (Anth-C) is associated with long-term cardiovascular mortality. Although cardiovascular risk assessment has traditionally focused on the heart, evidence has demonstrated that vascular dysfunction also occurs during and up to 1 year following Anth-C. Whether vascular dysfunction persists long-term or negatively influences cardiac function remains unknown. Hence, the present study evaluated ventricular-arterial coupling, in concert with measures of vascular structure and function, in the years following Anth-C. Methods. Arterial elastance (Ea), end-systolic elastance (Ees), and ventricular-arterial coupling (Ea/Ees) were measured during rest and exercise using echocardiography. Resting vascular function (flow-mediated dilation) and structure (carotid intima-media thickness, arterial stiffness) were also measured. Results. Thirty breast cancer survivors (6.5 6 3.6 years after Anth-C) with normal left ventricular ejection fraction

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Section: Discussionmentioning

confidence: 99%

Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

et al. 2016

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“…Systematyczny wysiłek aerobowy wydaje się obiecującą strategią redukcji dysfunkcji LV wywołanej przez doksorubicynę [284], ale nie dotyczy to kardiotoksyczności wywołanej przez trastuzumab [285].…”

Section: Leki Anty-her2unclassified

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Zamorano¹,

Lancellotti²,

Muñoz³

et al. 2016

Kardiol Pol

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“…Aerobic exercise training is recommended as a strategy to prevent the cardiotoxic effects of chemotherapy in patients (16). However, adherence to an exercise regimen with sufficient intensity and duration to provide cardioprotection is difficult for most patients undergoing chemotherapy (17); therefore the identification of new therapeutic interventions is necessary.…”

Section: Doxorubicin (Dox)mentioning

confidence: 99%

Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes

Cheung

Cole

Xiang

et al. 2015

Journal of Biological Chemistry

151

108

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Background: Doxorubicin is a chemotherapeutic agent that causes mitochondrial dysfunction and heart failure. The SIRT3 deacetylase regulates mitochondrial function. Results: Doxorubicin reduces SIRT3 expression. Increasing SIRT3 expression in doxorubicin-treated cardiomyocytes rescues mitochondrial respiration and reduces reactive oxygen species production. Conclusion: SIRT3 activation attenuates doxorubicin-induced mitochondrial dysfunction. Significance: SIRT3 activation could be a therapy for heart failure.

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Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer

Cited by 166 publications

References 91 publications

Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy

2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes

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