Modulation of AMPA receptor function by auxiliary subunits

Monyer, Hannah; Engelhardt, Jakob von

doi:10.1007/s13295-015-0005-z

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“…Additionally, highlighted are locations of specific domains of the different protein families: the PDZ binding motifs for TARPs and CKAMPs, the C‐terminal phosphorylation site of TARPs (that interacts with the cell membrane and influences synaptic anchoring) and the characteristic region of CKAMPs (cysteine‐rich region) and CNIH‐2/3 (adapted from Monyer & von Engelhardt, 2015 and Kamalova & Nakagawa, 2021). …”

Section: Introductionmentioning

confidence: 99%

Modulation of information processing by AMPA receptor auxiliary subunits

Jacobi

Engelhardt

2020

The Journal of Physiology

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AMPA-type glutamate receptors (AMPARs) are key molecules of neuronal communication in our brain. The discovery of AMPAR auxiliary subunits, such as proteins of the TARP, CKAMP and CNIH families, fundamentally changed our understanding of how AMPAR function is regulated. Auxiliary subunits control almost all aspects of AMPAR function in the brain. They influence AMPAR assembly, composition, structure, trafficking, subcellular localization and gating. This influence has important implications for synapse function. In the present review, we first discuss how auxiliary subunits affect the strength of synapses by modulating number and localization of AMPARs in synapses as well as their glutamate affinity, conductance and peak open probability. Next we explain how the presence of auxiliary subunits alters temporal precision and integrative properties of synapses by influencing gating kinetics of the receptors. Auxiliary subunits of the TARP and CKAMP family modulate synaptic short-term plasticity by Eric Jacobi holds a PhD from the University of Heidelberg and a Diploma in Human and Molecular Biology from Saarland University. Currently, he is a postdoctoral researcher and lecturer at the Institute for Pathophysiology of the University Medical Centre of the Johannes Gutenberg University Mainz. His research focus lays on the synaptic communication of neurons with a special emphasis on glutamatergic synapses. Jakob von Engelhardt received his MD at the Philipps-University Marburg. After his residency in neurology at the Department of Neurology of the University Hospital Heidelberg he did his postdoctoral work in the Department of Clinical Neurobiology in Heidelberg. In 2012, he became a group leader at the DZNE in Bonn and the DKFZ in Heidelberg. Since 2017 he has been Director of the Institute of Pathophysiology at the Johannes Gutenberg University Mainz. His main research interest is the regulation of excitatory synapse function and role of glutamate receptors in the CNS.

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Section: Introductionmentioning

confidence: 99%