2020
DOI: 10.3389/fimmu.2020.592186
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Modulation of Allergic Sensitization and Allergic Inflammation by Staphylococcus aureus Enterotoxin B in an Ovalbumin Mouse Model

Abstract: The superantigen Staphylococcus aureus (S. aureus) enterotoxin B (SEB) has been proposed a central player in the associations between S. aureus nasal colonization and the development of allergic asthma. Previously, SEB has been shown to aggravate allergic sensitization and allergic airway inflammation (AAI) in experimental mouse models. Aiming at understanding the underlying immunological mechanisms, we tested the hypothesis that intranasal (i.n.) SEB-treatment divergently modulates AAI depending on the timing… Show more

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Cited by 9 publications
(10 citation statements)
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“…Flow cytometry was performed as described [37]. Briefly, cells were incubated with anti-CD16/CD36 (2.4G2) to block Fc-receptors and were stained with fixable live/dead stain (BioLegend).…”
Section: Flow Cytometrymentioning
confidence: 99%
See 2 more Smart Citations
“…Flow cytometry was performed as described [37]. Briefly, cells were incubated with anti-CD16/CD36 (2.4G2) to block Fc-receptors and were stained with fixable live/dead stain (BioLegend).…”
Section: Flow Cytometrymentioning
confidence: 99%
“…Assessment of airway hyperreactivity was performed as described [37]. Anesthetized and tracheotomized mice were mechanically ventilated (Buxco FinePointe R/C, DSI TM USA) and after 5 min of acclimation, 10 µL PBS containing increasing concentrations of methacholine (0, 6.25, 12.5, 25, 50 mg/mL) were nebulized into the breathing air (delivery duration 20 s).…”
Section: Assessment Of Airway Hyperreactivitymentioning
confidence: 99%
See 1 more Smart Citation
“…There's some debate on the role of antibiotic therapy in the treatment of allergic disorders with concomitant bacterial infections (42,43). Although antibiotic treatment has different outcomes in asthma, chronic rhinitis, and nasal polyposis, the impact of S. aureus enterotoxins in allergic diseases is increasing (44)(45)(46)(47)(48)(49)(50)(51)(52). Staphylococcus aureus enterotoxins are thought to act as superantigens, inducing production of polyclonal IgE via Bcell and T-cell activation, and triggering release of inflammatory mediators (50).…”
Section: Discussionmentioning
confidence: 99%
“…Various studies suggest that exposure to S. aureus and its associated enterotoxins is a risk factor for the development of allergic asthma [ 125 ]. Experimentally, we recently showed that intranasally administered S. aureus enterotoxin B harbors a versatile potential to modulate allergic airway inflammation [ 126 ]. During S. aureus lung infection, nociceptors regulate protective immunity through CGRP release via the transient receptor potential ion channel 1 (TRPV1).…”
Section: Neuro-immune Crosstalk In Respiratory Infection and Microbial Colonizationmentioning
confidence: 99%