Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons

Suhr, Ralf; Balse, Elise; Haaf, Andreas; Kelche, Christian; Cassel, Jean‐Christophe; Jackisch, Rolf

doi:10.1016/s0361-9230(99)00083-0

Cited by 12 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gartside et al (1996) attributed this to a capability of unaltered serotonergic terminals to increase their releasable 5-HT pool. This interpretation is compatible with enhanced neurotransmitter release properties described in other lesion models (eg Suhr et al, 1999). Also the modulation of the 5-HT release via autoreceptors, which are of the 5-HT 1B subtype, was found to be normal in MDMA-treated rats.…”

Section: Long-term Effects Of Etoh And/or Mdma On Evoked 5-ht Releasesupporting

confidence: 89%

Ethanol, 3,4-Methylenedioxymethamphetamine (Ecstasy) and Their Combination: Long-Term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat

Cassel

Riegert

Rutz³

et al. 2005

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

This study investigated long-term behavioral, neurochemical, and neuropharmacological effects of ethanol-(7)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) combinations. Over 4 consecutive days, male Long-Evans rats received 1.5 g/kg ethanol and/or 10 mg/kg MDMA, or saline. Rectal temperatures were taken in some rats. Starting 4 days after the last injection, we tested working memory, sensory-motor coordination, and anxiety. Subsequently, we measured cortical, striatal, septal, and hippocampal monoamines (last MDMA injection-euthanasia delay: 20 days), or electrically evoked release of serotonin (5-HT) in cortical and hippocampal slices, and its modulation in the presence of CP 93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrollo[3,2-b]pyrid-5-one) or methiotepin (last MDMA injection-euthanasia delays: 3-6 weeks). Ethanol attenuated the MDMA-induced hyperthermia, but only on the first day. In the longterm, MDMA reduced 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) content in most brain regions. The behavioral and neurochemical effects of the ethanol-MDMA combination were comparable to those of MDMA alone; sensory-motor coordination was altered after ethanol and/or MDMA. In hippocampal slices from rats given ethanol and MDMA, the CP 93,129-induced inhibition and methiotepininduced facilitation of 5-HT release were stronger and weaker, respectively, than in the other groups. This is the first study addressing long-term effects of repeated MDMA and EtOH combined treatments in experimental animals. Whereas the drug combination produced the same behavioral and neurochemical effects as MDMA alone, our neuropharmacological results suggest that MDMA-EtOH interactions may have specific long-term consequences on presynaptic modulation of hippocampal 5-HT release, but not necessarily related to MDMA-induced depletion of 5-HT. Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA.

show abstract

Section: Long-term Effects Of Etoh And/or Mdma On Evoked 5-ht Releasesupporting

confidence: 89%

Ethanol, 3,4-Methylenedioxymethamphetamine (Ecstasy) and Their Combination: Long-Term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat

Cassel

Riegert

Rutz³

et al. 2005

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In analogy to these results, it is probable that the same type of presynaptic 5-HT heteroreceptor on cholinergic nerves is also involved in the inhibition of electrically evoked [ 3 H]ACh release in slices of the rat hippocampus (Maura et al, 1989;Vizi and Kiss, 1998), guinea pig caudate nucleus (Bianchi et al, 1989), and human neocortex (Feuerstein and Seeger, 1997) as well as K ϩ -induced [ 3 H]ACh release in rat striatal slices (Gillet et al, 1985;Jackson et al, 1988). A decrease in electrically evoked [ 3 H]ACh release by the 5-HT receptor agonist CP-93129 (in the absence of TTX) was also observed (5-9 months after grafting) in hippocampal slices from rats that had undergone electrolytic or aspirative (Suhr et al, 1999) fimbria-fornix lesions and 2 weeks later had received intrahippocampal suspension grafts of fetal septal tissue. The authors suggested on the basis of their results that inhibitory presynaptic heteroreceptors are also operative in grafted cholinergic neurons contained in hippocampal slices.…”

Section: A General Aspectsmentioning

confidence: 84%

5-HT Receptor Regulation of Neurotransmitter Release

Fink¹,

Göthert²

2007

Pharmacol Rev

323

View full text Add to dashboard Cite

“…Such slices contain many cholinergic neurons but seldom do more than compensate for the lesion-induced decrease of electrically-evoked release of [ 3 H]acetylcholine (e.g. Birthelmer et al, 2002;Suhr et al, 1999). Therefore, it seems reasonable to assume that at least part of the release of acetylcholine reported previously in the MS and the DBB (Disko et al, 1998(Disko et al, , 1999 originated from extrinsic afferents.…”

Section: Origin Of the Ach Released Within The Septal Regionmentioning

confidence: 99%

Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75ntr receptors? a study using 192 IgG-saporin lesions in rats

Birthelmer¹,

Lazaris

Riegert

et al. 2003

Neuroscience

View full text Add to dashboard Cite

Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons

Cited by 12 publications

References 50 publications

Ethanol, 3,4-Methylenedioxymethamphetamine (Ecstasy) and Their Combination: Long-Term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat

Ethanol, 3,4-Methylenedioxymethamphetamine (Ecstasy) and Their Combination: Long-Term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat

5-HT Receptor Regulation of Neurotransmitter Release

Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75ntr receptors? a study using 192 IgG-saporin lesions in rats

Contact Info

Product

Resources

About