Modulation by steroid hormones and other factors on the expression of aquaporin-1 and aquaporin-5

Skowrońska, Agnieszka; Tanski, Damian; Jaśkiewicz, Łukasz; Skowroński, Mariusz T.

doi:10.1016/bs.vh.2019.08.006

Cited by 4 publications

(1 citation statement)

References 109 publications

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“…AQPs 1, -2, -3, and -5 in the vagina are suggested to serve roles in tissue surface hydration [92], and in the uterus are proposed to maintain fluid homeostasis during peri-implantation and pregnancy [93,94]. Levels of AQP expression are dependent in part on hormonal signaling [93,95], controlled via steroid responsive promoters [96][97][98][99].…”

Section: Aquaporin Expression In Male and Female Reproductive Tissues And Cancersmentioning

confidence: 99%

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Khan

Ricciardelli

Yool

2021

Cells

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Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major organs. Increases in aquaporin expression are associated with greater severity of many cancers, particularly in augmenting motility and invasiveness for example in colon cancers and glioblastoma. However, potential roles of altered aquaporin (AQP) function in reproductive cancers have been understudied to date. Published work reviewed here shows distinct classes aquaporin have differential roles in mediating cancer metastasis, angiogenesis, and resistance to apoptosis. Known mechanisms of action of AQPs in other tissues are proving relevant to understanding reproductive cancers. Emerging patterns show AQPs 1, 3, and 5 in particular are highly expressed in breast, endometrial, and ovarian cancers, consistent with their gene regulation by estrogen response elements, and AQPs 3 and 9 in particular are linked with prostate cancer. Continuing work is defining avenues for pharmacological targeting of aquaporins as potential therapies to reduce female and male reproductive cancer cell growth and invasiveness.

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Section: Aquaporin Expression In Male and Female Reproductive Tissues And Cancersmentioning

confidence: 99%

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Khan

Ricciardelli

Yool

2021

Cells

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Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based approaches

Terefinko,

Dzimitrowicz,

Bielawska-Pohl

et al. 2024

Toxicology in Vitro

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Involvement of aquaporin 5 and Na-K-2Cl cotransporter 1 in the pathogenesis of primary focal hyperhidrosis: evidence from the primary sweat gland cell culture

Lin,

et al. 2024

American Journal of Physiology-Cell Physiology

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People with primary focal hyperhidrosis (PFH) usually have an overactive sympathetic nervous system, which can activate the sweat glands through the chemical messenger of acetylcholine. The role of aquaporin 5 (AQP5) and Na-K-2Cl co-transporter 1 (NKCC1) in PFH is still unknown. The relative mRNA and protein levels of AQP5 and NKCC1 in the sweat gland tissues of three subtypes of PFH patients (primary palmar hyperhidrosis, PPH; primary axillary hyperhidrosis, PAH; primary craniofacial hyperhidrosis, PCH) were detected with Real-Time PCR (qPCR) and Western blot. Primary sweat gland cells from healthy controls (NPFH-SG) were incubated with different concentrations of acetylcholine, and the relative mRNA and protein expression of AQP5 and NKCC1 were also detected. NPFH-SG cells were also transfected with si-AQP5 or shNKCC1, and acetylcholine stimulation-induced calcium transients were assayed with Fluo-3 AM calcium assay. Up-regulated AQP5 and NKCC1 expression were observed in sweat gland tissues, and AQP5 demonstrated a positive Pearson correlation with NKCC1 in PPH patients ( r=0.66, p<0.001), PAH patients ( r=0.71, p<0.001), and PCH patients ( r=0.62, p<0.001). Up-regulated AQP5 and NKCC1 expression were also detected in primary sweat gland cells derived from three subtypes of PFH patients when compared with primary sweat gland cells derived from healthy control. Acetylcholine stimulation could induce the up-regulated AQP5 and NKCC1 expression in NPFH-SG cells, and AQP5 or NKCC1 inhibitions attenuated the calcium transients induced by acetylcholine stimulation in NPFH-SG cells. The dependence of ACh-stimulated calcium transients on AQP5 and NKCC1 expression may be involved in the development of PFH.

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Modulation by steroid hormones and other factors on the expression of aquaporin-1 and aquaporin-5

Cited by 4 publications

References 109 publications

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based approaches

Involvement of aquaporin 5 and Na-K-2Cl cotransporter 1 in the pathogenesis of primary focal hyperhidrosis: evidence from the primary sweat gland cell culture

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