Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome

Hashinaga, Toshihiko; Wada, Nobuhiko; Otabe, Shuichi; Yuan, Xiaohong; Kurita, Yayoi; Kakino, Satomi; Tanaka, Kayo; Sato, Takahiro; Kojima, Masayasu; Ohki, Tsuyoshi; Nakayama, Hitomi; Egashira, Tomoka; Tajiri, Yuji; Yamada, Kentaro

doi:10.1507/endocrj.ej12-0305

Cited by 28 publications

(24 citation statements)

References 34 publications

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“…Clock gene rhythms are phase-advanced in the liver and skeletal muscle in these mice. The introduction of the human adiponectin transgene into the liver of these mice restores locomotor rhythmicity, as well as hepatic clock gene phase (Hashinaga et al 2013). These studies strongly indicate that leptin, adiponectin, and maybe other adipokines may have direct effects on molecular clock function.…”

Section: Leptin and Adiponectinmentioning

confidence: 80%

Interactions between endocrine and circadian systems

Tsang¹,

Barclay

Oster

2013

Journal of Molecular Endocrinology

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

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Section: Leptin and Adiponectinmentioning

confidence: 80%

Interactions between endocrine and circadian systems

Tsang¹,

Barclay

Oster

2013

Journal of Molecular Endocrinology

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“…Both adiponectin and FGF15/19 are involved in regulating circadian rhythms, 83,84 autophagy 85,86 and ER stress 87,88 . Therefore, it is worthwhile to explore whether and how adiponectin-FGF15/19 signaling ameliorates these disturbed processes, and subsequently attenuates inflammatory responses and alleviates liver injury in response to ethanol challenge.…”

Section: Discussionmentioning

confidence: 99%

Endocrine Adiponectin‐FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury

et al. 2018

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Alcoholic liver disease (ALD) is the most prevalent form of liver diseases, encompassing a spectrum of progressive pathological changes from steatosis to steatohepatitis to fibrosis/cirrhosis and hepatocellular carcinoma. Alcoholic steatosis/steatohepatitis is the initial stage of ALD and a major risk factor for advanced liver injuries. Adiponectin is a hormone secreted from adipocytes. Fibroblast growth factor (FGF) 15 (human homolog, FGF19) is an ileum-derived hormone. Adipocyte-derived adiponectin and gut-derived FGF15/19 regulate each other, share common signaling cascades and exert similar beneficial functions. Emerging evidence has revealed that dysregulated adiponecitn-FGF15/19 axis and impaired hepatic adiponectin-FGF15/19 signaling are associated with alcoholic liver damage in rodents and humans. More importantly, endocrine adiponectin-FGF15/19 signaling confers protection against ethanol-induced liver damage via fine-tuning the adipose-intestine-liver crosstalk, leading to limited hepatic inflammatory responses, and ameliorated alcoholic liver injury. This review is focused on the recently discovered endocrine adiponectin-FGF15/19 axis that is emerging as an essential adipose-gut-liver coordinator involved in the development and progression of alcoholic steatohepatitis.

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“…Also, circadian gene expression was shifted in the liver and skeletal muscle. Restoring the adiponectin gene expression in the liver resulted in the recovery of the correct locomotor activity pattern, together with hepatic clock gene expression [144]. …”

Section: Circadian Clock In Hormonal Homeostasismentioning

confidence: 99%

Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications

Gnocchi

Bruscalupi

2017

Biology

103

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Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation of our physiology, including hormonal and metabolic homeostasis. Here we will review the structure, organisation and molecular machinery that make our circadian clock work, and its relevance for the proper functioning of physiological processes. We will also describe the interconnections between circadian rhythms and endocrine homeostasis, as well as the underlying consequences that circadian dysregulations might have in the development of several pathologic affections. Finally, we will discuss how a better knowledge of such relationships might prove helpful in designing new therapeutic approaches for endocrine and metabolic diseases.

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Modulation by adiponectin of circadian clock rhythmicity in model mice for metabolic syndrome

Cited by 28 publications

References 34 publications

Interactions between endocrine and circadian systems

Interactions between endocrine and circadian systems

Endocrine Adiponectin‐FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury

Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications

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