Modulating the properties of sunflower oil based novel emulgels using castor oil fatty acid ester: Prospects for topical antimicrobial drug delivery

Behera, Beauty; Biswal, Dibyajyoti; Uvanesh, K.; Srivastava, Anand; Bhattacharya, Mrinal; Paramanik, K.; Pal, Kunal

doi:10.1016/j.colsurfb.2015.02.026

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…Moreover, in the present study, in case of Figure 2B of the FTIR spectral analysis, the slight deflection in the characterization peak was due to the inclusion of the squalene into the agar. [29][30][31] Histopathological findings further substantiated the tissue regeneration within the damaged burnt skin portions. Moreover, the results indicate that when compared with negative control and agar gels, this squalene-loaded emulgel scaffold was not only biodegradable but also favors the cellular proliferation with excellent extracellular matrix.…”

Section: Discussionmentioning

confidence: 77%

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Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Shanmugarajan

Selvan

Uppuluri

2020

The International Journal of Lower Extremity Wounds

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Full-thickness burns pose a major challenge for clinicians to handle because of their restricted self-healing ability. Even though several approaches have been implemented for repairing these burnt skin tissue defects, all of them had unsatisfactory outcomes. Moreover, during recent years, skin tissue engineering techniques have emerged as a promising approach to improve skin tissue regeneration and overcome the shortcomings of the traditional approaches. Although previous literatures report the wound healing effects of the squalene oil, in the current study, for the first time, we developed a squalene-loaded emulgel-based scaffold as a novel approach for potential skin regeneration. This squalene-loaded agar-based emulgel scaffold was fabricated by using physical cross-linking technique using lecithin as an emulsifier. Characterization studies such as X-ray diffraction, Fourier-transform infrared spectroscopy, and field emission scanning electron microscopy revealed the amorphous nature, chemical interactions, and cross-linked capabilities of the developed emulgel scaffold. The squalene-loaded emulgel scaffold showed excellent wound contraction when compared with the agar gel and negative control. In case of the histopathology and recent immunohistochemistry findings, it was clearly evidenced that squalene-loaded emulgel promoted faster rate of the revascularization and macrophage polarization in order to enhance the burn wound healing. Moreover, the findings also revealed that the incorporation of squalene oil into the formulation enhances collagen deposition and accelerates the burnt skin tissue regeneration process. Finally, we conclude that the squalene-loaded emulgel scaffold could be an effective formulation used in the treatment of the burnt skin tissue defects.

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Section: Discussionmentioning

confidence: 77%

“…Prior to FTIR characterization, samples were freeze-dried for 72 hours and about 1 mg of squalene-loaded emulgel scaffold and agar gels was used for this study. 26,[28][29][30][31][32][33]…”

Section: Ftir Analysismentioning

confidence: 99%

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Shanmugarajan

Selvan

Uppuluri

2020

The International Journal of Lower Extremity Wounds

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“…[ 55 ] Also, the slow release of curcumin from 1.5%+curcumin and 2%+curcumin could be related to an increase in the overall hydrophobicity of gelled emulsions. Moreover, Behera et al [ 20 ] reported that a high concentration of PGPR increases the hydrophobic interactions into the gelled systems, and this type of interactions cause shrinkage of the structured gelled emulsions, diminishing the osmotic pressure [ 56 ] and provoking the swelling of structured emulsions. [ 57 ] Ngwabebhoh et al., [ 58 ] reported a 12% of curcumin release at 24 h fusing Pickering emulsion stabilized by nanocellulosic nanoparticles, in comparison with results obtained in the present experiment at the same time (24 h, 17–25%).…”

Section: Resultsmentioning

confidence: 99%

“…[ 19 ] Moreover, the physical and release properties of the structured emulsions can be modulated by incorporating PGPR in various proportions (Behera et al. [ 20 ] ; Contreras‐Ramírez et al. [ 20 ,12] ).…”

Section: Introductionmentioning

confidence: 99%

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A Water in Oil Gelled Emulsion as a Topical Release Vehicle for Curcumin

et al. 2022

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The objective of this work is to assess the influence of the concentration of polyglycerol polyricinoleate (PGPR) (at 1%, 1.5%, and 2%) on the physical properties of water in oil gelled emulsions (W/O) and evaluates their efficiency as a delivery vehicle for curcumin. Emulsions are characterized by drop size, centrifugal test, texture, and rheology during 28 days of storage. When the surfactant concentration increases, smaller droplet sizes are obtained (<5 µm), the phase separation (tested by centrifugal force) decreases from 6% to 4% with little variation of the time. The mechanical properties of emulsions show a tendency to decrease as time passed and concentration of PGPR increased. The emulsions increased viscosity as the concentration increased, but the addition of curcumin reduce the viscosity of the emulsions. About controlled release profiles, a low concentration of PGPR shows an increase in the affinity between curcumin and the emulsions, following a pseudo‐Fickian release behavior. At higher concentration of PGPR shows a decrease in the affinity between curcumin and the emulsion, displaying a Fickian release behavior. The authors were able to prepare tailor made curcumin water in oil emulsion systems for the topical release of this compound.

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Influence of nanoemulsion/gum ratio on droplet size distribution, rheology and physical stability of nanoemulgels containing inulin and omega‐3 fatty acids

et al. 2022

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Background New consumer habits are forcing the food industry to develop new and healthy products. In response to this tendency, in this investigation, we obtained nanoemulgels by microfluidization containing inulin fibre and omega‐3 fatty acids. First, the influence of the number of microfluidization cycles on the physical properties of the nanoemulsions was studied. Subsequently, an advanced‐performance xanthan gum was added to the nanoemulsion in different nanoemulsion/xanthan ratios (1:1, 2:1, 3:1, 4:1, 1:2, and 1:3). Results Laser diffraction, multiple light scattering, and rheology techniques were used to characterize nanoemulsions and the corresponding nanoemulgels. The nanoemulsion with the lowest Sauter mean diameter (138 nm) and the longest physical stability was obtained after three passes through a microfluidization device at a fixed pressure of 103 421 kPa. Thus, these processing conditions were always used to obtain the nanoemulsion; these were subsequently mixed with a xanthan gum solution to produce nanoemulgels that showed weak gel‐like viscoelastic and shear‐thinning flow behaviours. A decrease in the nanoemulsion/xanthan ratio (i.e. by an increase in the content of xanthan gum in the nanoemulgel) increased the viscoelastic moduli and the zero shear viscosity values. A rise in the droplet size was observed with aging time, probably due to flocculation. The nanoemulsion/xanthan gum mass ratio of 1:3 yielded the most stable nanoemulgel. Conclusions This work is a contribution to the development of functional foods. It has been demonstrated that it is possible to obtain a stable nanoemulgel‐based food matrix containing fibre and omega‐3 fatty acids. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Modulating the properties of sunflower oil based novel emulgels using castor oil fatty acid ester: Prospects for topical antimicrobial drug delivery

Cited by 18 publications

References 35 publications

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

A Water in Oil Gelled Emulsion as a Topical Release Vehicle for Curcumin

Influence of nanoemulsion/gum ratio on droplet size distribution, rheology and physical stability of nanoemulgels containing inulin and omega‐3 fatty acids

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