Modulating the movement of hydrogel actuator based on catechol–iron ion coordination chemistry

Lee, Bruce P.; Lin, Ming‐Yuan; Narkar, Ameya; Konst, Shari; Wilharm, Randall K.

doi:10.1016/j.snb.2014.09.089

Cited by 63 publications

(48 citation statements)

References 47 publications

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“…[ 62 ] The viscoelastic behavior of P(HEMA-co -DMA) hydrogels in this study is consistent with previous reports of catechol-bearing hydrogels. [ 62,63 ] Taken together, the mechanical properties of P(HEMA) hydrogels are largely preserved despite incorporating DMA.…”

Section: Communicationmentioning

confidence: 97%

Transfer Printing of Metallic Microstructures on Adhesion‐Promoting Hydrogel Substrates

Sariola

Zhu

et al. 2015

Advanced Materials

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Section: Communicationmentioning

confidence: 97%

Transfer Printing of Metallic Microstructures on Adhesion‐Promoting Hydrogel Substrates

Sariola

Zhu

et al. 2015

Advanced Materials

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“…Inert, synthetic polymers modified with DOPA and other catechol derivatives (i.e., dopamine) have demonstrated strong, water-resistant adhesive properties to various biological, metallic and polymeric substrates [3–5]. The simplicity and versatility of catechol chemistry has been exploited in designing functional biomaterials for a wide range of applications including tissue adhesive and sealant [6–8], antimicrobial polymer [9], drug carrier [10], surface coating [11, 12], and soft actuator [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety

Meng

Faust

et al. 2015

Acta Biomaterialia

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To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of H2O2 when its catechol side chain oxidized to quinone. Introduction of catalase at a concentration as low as 7.5 U/mL counteracted the cytotoxic effect of H2O2 and enhanced the viability and proliferation rate of fibroblasts. These results indicated that H2O2 generation is one of the main contributors to the cytotoxicity of dopamine in culture. Additionally, catalase is a potentially useful supplement to suppress the elevated oxidative stress found in typical culture conditions and can more accurately evaluate the biocompatibility of mussel-mimetic biomaterials. The release of H2O2 also induced a higher foreign body reaction to catechol-modified hydrogel when it was implanted subcutaneously in rat. Given that H2O2 has a multitude of biological effects, both beneficiary and deleterious, regulation of H2O2 production from catechol-containing biomaterials is necessary to optimize the performance of these materials for a desired application.

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“…The equilibrium water content (EWC) of these nanocomoposite hydrogels was between 92 and 97 wt% (Figure ). EWC is an important property of a hydrogel and is inversely proportional to the crosslinking density and mechanical properties of the network . At all the pH levels tested, the EWC values of PAAm‐D and PAAm‐ND hydrogels were significantly lower than those of PAAm.…”

Section: Resultsmentioning

confidence: 94%

“…However, the effect of pH on the material properties of these nanocomposites has not yet been reported. pH plays an important role in the oxidation state of catechol and its ability to bind to metal oxide and ions . When the pH approaches and exceeds the first dissociation constant of the catecholOH group (p K a 1 = 9.0), DOPA auto‐oxidizes to its quinone form with reduced adhesive strength …”

Section: Introductionmentioning

confidence: 99%

“…pH plays an important role in the oxidation state of catechol and its ability to bind to metal oxide and ions. [25][26][27] When the pH approaches and exceeds the fi rst dissociation constant of the catechol OH group (p K a 1 = 9.0), DOPA auto-oxidizes to its quinone form with reduced adhesive strength. [ 18,25,28 ] DOPA is also found in adhesive proteins utilized by sandcastle worms to cement sand fragments into tubeshaped dwellings.…”

Section: Introductionmentioning

confidence: 99%

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Nitro-Group Functionalization of Dopamine and its Contribution to the Viscoelastic Properties of Catechol-Containing Nanocomposite Hydrogels

Ding

Vegesna

Meng

et al. 2015

Macromol. Chem. Phys.

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Linear polyacrylamide (PAAm) is modified with dopamine or nitrodopamine (PAAm-D and PAAm-ND, respectively) to evaluate the effect of nitro-group modification on the interfacial binding properties of polymer-bound catechol. Nanocomposite hydrogels are prepared by mixing PAAm-based polymers with Laponite and the viscoelastic properties of these materials are determined using oscillatory rheometry. The incorporation of a small amount of catechol (≈0.1 wt% in swollen hydrogel) drastically increases the shear moduli by 1–2 orders of magnitude over those of the catechol-free control. Additionally, PAAm-ND exhibits higher shear moduli values than PAAm-D across the whole pH range tested (pH 3.0–9.0). Based on the calculated effective crosslinking density, effective functionality, and molecular weight between crosslinks, nitro-group functionalization of dopamine results in a polymer network with increased crosslinking density and crosslinking points with higher functionality. Nitro-functionalization enhances the interfacial binding property of dopamine and increases its resistant to oxidation, which results in nanocomposite hydrogels with enhanced stiffness and a viscous dissipation property.

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Modulating the movement of hydrogel actuator based on catechol–iron ion coordination chemistry

Cited by 63 publications

References 47 publications

Transfer Printing of Metallic Microstructures on Adhesion‐Promoting Hydrogel Substrates

Transfer Printing of Metallic Microstructures on Adhesion‐Promoting Hydrogel Substrates

Hydrogen peroxide generation and biocompatibility of hydrogel-bound mussel adhesive moiety

Nitro-Group Functionalization of Dopamine and its Contribution to the Viscoelastic Properties of Catechol-Containing Nanocomposite Hydrogels

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