Modulating the DNA/Lipid Interface through Multivalent Hydrophobicity
Siu Ho Wong,
Sarina Nicole Kopf,
Vincenzo Caroprese
et al.
Abstract:Lipids and nucleic acids are two of the most abundant components of our cells, and both molecules are widely used as engineering materials for nanoparticles. Here, we present a systematic study of how hydrophobic modifications can be employed to modulate the DNA/lipid interface. Using a series of DNA anchors with increasing hydrophobicity, we quantified the capacity to immobilize doublestranded (ds) DNA to lipid membranes in the liquid phase. Contrary to electrostatic effects, hydrophobic anchors are shown to … Show more
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