Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization

Moreno, Miguel; Pow, Poh Yih; Tabitha, T.S.; Nirmal, Sonali; Larsson, Andreas; Radhakrishnan, Krishna; Nirmal, Jayabalan; Quah, Soo Tng; Shochat, Susana Geifman; Agrawal, Rupesh; Venkatraman, Subbu

doi:10.1080/17425247.2017.1343297

Cited by 29 publications

(13 citation statements)

References 41 publications

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“…The non-systemic routes involve localised use of therapeutic antibodies where antibodies are injected, either at or near the area of disease or injury, allowing direct diffusion of the antibody to the region of the target site where a therapeutic effect is expected (Jones and Martino 2016 ). Ranibizumab, used for the treatment of wet age-related macular degeneration, a disease of the eye, is the first monoclonal antibody approved for targeted localised therapy by the Federal Drug Administration (FDA) and is recommended to be administered by intravitreal injection once a month (Moreno et al 2017 ). The other non-systemic routes that have potentially been explored in recent years are the fistula tract, localised subcutaneous, intratumoural, peritumoural, and intranasal delivery (Fig.…”

Section: Systemic Versus Inhalation Routementioning

confidence: 99%

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

Parray

Shukla

Perween

et al. 2021

Appl Microbiol Biotechnol

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The route of administration of a therapeutic agent has a substantial impact on its success. Therapeutic antibodies are usually administered systemically, either directly by intravenous route, or indirectly by intramuscular or subcutaneous injection. However, treatment of diseases contained within a specific tissue necessitates a better alternate route of administration for targeting localised infections. Inhalation is a promising non-invasive strategy for antibody delivery to treat respiratory maladies because it provides higher concentrations of antibody in the respiratory airways overcoming the constraints of entry through systemic circulation and uncertainity in the amount reaching the target tissue. The nasal drug delivery route is one of the extensively researched modes of administration, and nasal sprays for molecular drugs are deemed successful and are presently commercially marketed. This review highlights the current state and future prospects of inhaled therapies, with an emphasis on the use of monoclonal antibodies for the treatment of respiratory infections, as well as an overview of their importance, practical challenges, and clinical trial outcomes. Key points • Immunologic strategies for preventing mucosal transmission of respiratory pathogens. • Mucosal-mediated immunoprophylaxis could play a major role in COVID-19 prevention. • Applications of monoclonal antibodies in passive immunisation.

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Section: Systemic Versus Inhalation Routementioning

confidence: 99%

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

Parray

Shukla

Perween

et al. 2021

Appl Microbiol Biotechnol

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“…A slow and stable swelling process resulting in robust and firm networks is desired for applications such as wound healing, where high amounts of exudate can occur over an extended time period. 44 , 137 …”

Section: Properties Of Thiolated Chitosansmentioning

confidence: 99%

“…As the release profile and retention of these two drugs out of the hydrogels were comparable to those of fluorescein isothiocyanate–dextran, with an average molecular weight of 40 kDa, physical entrapment in the gel systems was identified as the main cause for sustained drug release. 44 …”

Section: Properties Of Thiolated Chitosansmentioning

confidence: 99%

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

2020

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Various properties of chitosan can be customized by thiolation for very specific needs in a wide range of application areas. Since the discovery of thiolated chitosans, many studies have proven their advantageous characteristics, such as adhesion to biological surfaces, adjustable cross-linking and swelling behavior, controllable drug release, permeation as well as cellular uptake enhancement, inhibition of efflux pumps and enzymes, complexation of metal ions, antioxidative properties, and radical scavenging activity. Simultaneously, these polymers remain biodegradable without increased toxicity. Within this Review, an overview about the different possibilities to covalently attach sulfhydryl ligands to the polymeric backbone of chitosan is given, and the resulting versatile physiochemical properties are discussed in detail. Furthermore, the broad spectrum of applications for thiolated chitosans in science and industry, ranging from their most advanced use in pharmaceutical and medical science over wastewater treatment to the impregnation of textiles, is addressed.

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“…Monoclonal antibodies were delivered from thiolate CH hydrogels for ocular administration. 95 Covalent-cross-linked carboxymethyl CH hydrogel was also implemented for the codelivery of bevacizumab and 5-fluorouracil to treat postoperative scarring in a rabbit model of experimental glaucoma filtration surgery. 96 In another study, a dynamic covalent Schiff-base bond was used for the formation of glycol-CH and oxidized ALG for the release of the same monoclonal antibody for the treatment of age-related macular degeneration.…”

Section: Controlled Delivery Of Therapeutic Biomolecules From Polysac...mentioning

confidence: 99%

Recent Progress on Polysaccharide-Based Hydrogels for Controlled Delivery of Therapeutic Biomolecules

Rial-Hermida

Rey‐Rico

Blanco-Fernandez

et al. 2021

ACS Biomater. Sci. Eng.

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A plethora of applications using polysaccharides have been developed in recent years due to their availability as well as their frequent nontoxicity and biodegradability. These polymers are usually obtained from renewable sources or are byproducts of industrial processes, thus, their use is collaborative in waste management and shows promise for an enhanced sustainable circular economy. Regarding the development of novel delivery systems for biotherapeutics, the potential of polysaccharides is attractive for the previously mentioned properties and also for the possibility of chemical modification of their structures, their ability to form matrixes of diverse architectures and mechanical properties, as well as for their ability to maintain bioactivity following incorporation of the biomolecules into the matrix. Biotherapeutics, such as proteins, growth factors, gene vectors, enzymes, hormones, DNA/RNA, and antibodies are currently in use as major therapeutics in a wide range of pathologies. In the present review, we summarize recent progress in the development of polysaccharide-based hydrogels of diverse nature, alone or in combination with other polymers or drug delivery systems, which have been implemented in the delivery of biotherapeutics in the pharmaceutical and biomedical fields.

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Modulating release of ranibizumab and aflibercept from thiolated chitosan-based hydrogels for potential treatment of ocular neovascularization

Abstract: The disc-shaped thiolated chitosan-based hydrogels provide a potentially useful platform to deliver ranibizumab and aflibercept for the treatments of ocular diseases such as wet AMD, DME and corneal neovascularization.

Cited by 29 publications

References 41 publications

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications

Recent Progress on Polysaccharide-Based Hydrogels for Controlled Delivery of Therapeutic Biomolecules

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