Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles

Ijaz, Sahar; Mohammed, Ibrahim; Gholaminejhad, Morteza; Mokhtari, Tahmineh; Akbari, Mohammad; Hassanzadeh, Gholamreza

doi:10.1007/s12031-019-01437-2

Cited by 25 publications

(17 citation statements)

References 42 publications

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Section: Neurogenesis and Neuroplasticity In The Hippocampus Following Chronic Pain And Depressionmentioning

confidence: 99%

“…Hippocampal abnormalities, including impaired neuroplasticity and enriched-environment neurogenesis, have been associated with a different mechanism in chronic pain conditions [53]. At least two specific anatomical regions, the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus, have been reported to be involved in the neurogenesis of the adult mammalian brain [54,55]. Adult hippocampal neurogenesis is associated with learning and memory [56], and findings suggest that reduced neurogenesis in the hippocampus region is involved in various neuropsychiatric disorders, including anxiety [57], depression [58], stress [59], and impaired contextual fear conditioning [60].…”

Section: Neurogenesis and Neuroplasticity In The Hippocampus Following Chronic Pain And Depressionmentioning

confidence: 99%

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Involvement of the hippocampus in chronic pain and depression

Mokhtari

2019

Brain Science Advances

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Increases in depressive behaviors have been reported in patients experiencing chronic pain. In these patients, the symptoms of pain and depression commonly coexist, impairing their lives and challenging effective treatment. The hippocampus may play a role in both chronic pain and depression. A reduction in the volume of the hippocampus is related to reduced neurogenesis and neuroplasticity in cases of chronic pain and depression. Moreover, an increase of proinflammatory factors and a reduction of neurotrophic factors have been reported to modulate the hippocampal neurogenesis and neuroplasticity in chronic pain and depression. This review discusses the mechanisms underlying the depressive-like behavior accompanying chronic pain, emphasizing the structural and functional changes in the hippocampus. We also discuss the hypothesis that pro-inflammatory factors and neurotrophic factors expressed in the hippocampus may serve as a therapeutic target for comorbid chronic pain and depression.

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Section: Neurogenesis and Neuroplasticity In The Hippocampus Following Chronic Pain And Depressionmentioning

confidence: 99%

Section: Neurogenesis and Neuroplasticity In The Hippocampus Following Chronic Pain And Depressionmentioning

confidence: 99%

Involvement of the hippocampus in chronic pain and depression

Mokhtari

2019

Brain Science Advances

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“…These studies demonstrated that transplanted stem cells from different sources from human can reduce the inflammation by inhibit the formation and also action of inflammasome complexes and consequently prevent the secondary injury in nervous system. [37][38][39] Brain and blood miRNAs helped the transplanted cells to progress the regeneration process. miRNAs keep the neural cells survived in hypoxic environment by regulating different pathway that activates in this critical condition.…”

Section: Discussionmentioning

confidence: 99%

Human embryonic derived neural progenitor cells improves neurological scores following brain ischemia/ reperfusion: Modulation of blood and brain tissue MicroRNA-210

Arab

Fanni

Nemati

et al. 2020

J. Contemp. Med. Sci.

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Objective: In this study, we evaluated the effects of human embryonic derived neural progenitor cells on neurological score, histopathological changes, and miRNA-210 as biomarkers of regeneration. Methods: The animals were randomly divided into the four groups: Sh (sham), MCAO (middle cerebral artery occlusion), MCAO+PBS, MCAO+Cell. One day after MCAO induction, embryonic derived neural progenitor cells (hESC-NPCsGFP) or PBS were injected intracerebroventriculary in MCAO+Cell or MCAO+PBS groups. On day 1, 2, 3, and 7 after ischemia induction, the neurological score was tested in each rat. At 48h, the expression of miRNA-210 was evaluated and 7 days after, the pathological assessments were performed by H&E staining. Results: Neurological score showed the promotion of functional recovery in MCAO+Cell group. Based on H&E staining, the percentage of neural death in ischemic region reduced in MCAO+Cell group. The miRNA-210 significantly upregulated in both brain and blood samples. Conclusion: According to the findings, hESC-NPCsGFP injection could up-regulate the miRNA-210 of tissue and blood to support the neuroprotective and regenerative effect of hESC-NPCsGFP in the ischemic lesion and improved the neurological score and reduce the neural death in ischemic region.

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“…Finally, to quantify the speci c bands, ImageJ software (NIH, USA) was used. GAPDH (Thermoscienti c, USA) was used for normalization [33].…”

Section: Western Blotmentioning

confidence: 99%

Intraventricular T3 reverses chronic restraint stress-induced depressive-like behaviors: Inhibition of NF-κB/ NLRP3 inflammasome pathway in the hippocampus

Mokhtari

El-Kenawy

2021

Preprint

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In this study, the effects of triiodothyronine (T3) were evaluated on the NLR family pyrin domain containing 3 (NLRP3) inflammasome complex formation in the rat's hippocampus with restraint stress-induced depressive-like behaviors.Thirty-six Wistar male rats were randomly allocated to following groups: Control, Model, and Model + T3. In the Model or Model+T3 group, a single dose of PBS or T3 was administered into the lateral ventricle. Depressive-like behaviors were induced by chronic restraint stress. The forced swimming (FST), tail suspension (TST), and open field (OFT) tests were used to investigate the depression. The rats were sacrificed, and brain tissues were stored for molecular and pathological evaluations. Chronic stress increased the immobility of rats in the Model group according to FST, TST, and OFT (P < 0.05). T3 significantly improved depressive-like behaviors (P < 0.05). The gene expression and protein level of hippocampal nuclear factor kappa B (NF-κB), NLRP3, apoptosis-associated speck-like protein (ASC), and Caspase-1 significantly increased in the Model group compared to the control group (P < 0.05). The reduced hippocampal levels of NF-κB, NLRP3, ASC, and Caspase-1 were observed in the T3 group compared to the Model group (P < 0.05). The Nissl staining of the CA1 region showed an increased number of dark neurons (P < 0.05) and reduced pyramidal layer thickness (P < 0.05) in the Model group. These histopathological alterations were changed by T3 administration compared to the Model group (P < 0.05). The findings confirmed the therapeutic effects of intraventricularly T3 on depressive-like behaviors induced by restraint stress via surviving pyramidal neurons of the CA1 region and inhibition of NF-κB/NLRP3 inflammasome pathway.

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Modulating Pro-inflammatory Cytokines, Tissue Damage Magnitude, and Motor Deficit in Spinal Cord Injury with Subventricular Zone-Derived Extracellular Vesicles

Cited by 25 publications

References 42 publications

Involvement of the hippocampus in chronic pain and depression

Involvement of the hippocampus in chronic pain and depression

Human embryonic derived neural progenitor cells improves neurological scores following brain ischemia/ reperfusion: Modulation of blood and brain tissue MicroRNA-210

Intraventricular T3 reverses chronic restraint stress-induced depressive-like behaviors: Inhibition of NF-κB/ NLRP3 inflammasome pathway in the hippocampus

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