Modulating NO–GC Pathway in Pulmonary Arterial Hypertension
Anna D’Agostino,
Lorena Gioia Lanzafame,
Lorena Buono
et al.
Abstract:The pathogenesis of complex diseases such as pulmonary arterial hypertension (PAH) is entirely rooted in changes in the expression of some vasoactive factors. These play a significant role in the onset and progression of the disease. Indeed, PAH has been associated with pathophysiologic alterations in vascular function. These are often dictated by increased oxidative stress and impaired modulation of the nitric oxide (NO) pathway. NO reduces the uncontrolled proliferation of vascular smooth muscle cells that l… Show more
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