“…Moreover, although prior studies have implicated diverse mito-nuclear interactions in the selfish propagation of mitochondrial mutations, 26,29,32,34,36,41 as well as substantial variation in their phenotypic effects, 42,43 this work spans multiple species. 18,27,29 Because animal species vary widely in ways that affect mitochondrial genome biology, including nuclear genome composition, development and organization of the germline, and environmental context, 29,44 these numerous confounding factors have strongly limited our ability to draw general conclusions about the evolutionary dynamics of selfish mitochondrial genomes.…”