Modulating Lipid Membrane Morphology by Dynamic DNA Origami Networks

Yang, Juanjuan; Jahnke, Kevin; Xin, Ling; Jing, Xinxin; Zhan, Pengfei; Peil, Andreas; Griffo, Alessandra; Škugor, Marko; Yang, Donglei; Fan, Sisi; Göpfrich, Kerstin; Yan, Hao; Wang, Pengfei; Liu, Na

doi:10.1021/acs.nanolett.3c00750

Cited by 4 publications

(1 citation statement)

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“…Advancements in nanophotonics have broadened its capacities to encompass advanced functionalities. For instance, nanoantennas are vital nanophotonic components constructed from metals (7)(8)(9)(10), dielectrics (11), or even DNA (12)(13)(14). Nanoantenna-enabled trace detection in hyperspectral imaging has been demonstrated through enhanced light-molecule interactions (3), known as surface-enhanced IR absorption spectroscopy (SEIRAS) (15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Surface plasmons-phonons for mid-infrared hyperspectral imaging

Zhou,

Li,

Ren

et al. 2024

Sci. Adv.

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Surface plasmons have proven their ability to boost the sensitivity of mid-infrared hyperspectral imaging by enhancing light-matter interactions. Surface phonons, a counterpart technology to plasmons, present unclear contributions to hyperspectral imaging. Here, we investigate this by developing a plasmon-phonon hyperspectral imaging system that uses asymmetric cross-shaped nanoantennas composed of stacked plasmon-phonon materials. The phonon modes within this system, controlled by light polarization, capture molecular refractive index intensity and lineshape features, distinct from those observed with plasmons, enabling more precise and sensitive molecule identification. In a deep learning–assisted imaging demonstration of severe acute respiratory syndrome coronavirus (SARS-CoV), phonons exhibit enhanced identification capabilities (230,400 spectra/s), facilitating the de-overlapping and observation of the spatial distribution of two mixed SARS-CoV spike proteins. In addition, the plasmon-phonon system demonstrates increased identification accuracy (93%), heightened sensitivity, and enhanced detection limits (down to molecule monolayers). These findings extend phonon polaritonics to hyperspectral imaging, promising applications in imaging-guided molecule screening and pharmaceutical analysis.

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Section: Introductionmentioning

confidence: 99%

Surface plasmons-phonons for mid-infrared hyperspectral imaging

Zhou,

Li,

Ren

et al. 2024

Sci. Adv.

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Artificial Molecular Systems for Complex Functions Based on DNA Nanotechnology and Cell‐Sized Lipid Vesicles

Sato

2024

ChemSystemsChem

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Cells are highly functional and complex molecular systems. Artificially creating such systems remains a challenge, which has been extensively studied in various research fields, including synthetic biology and molecular robotics. DNA nanotechnology is a powerful tool for bottom‐up engineering for constructing functional nanostructures or chemical reaction networks which can be utilized as components for artificial molecular systems. Encapsulation of these components into a giant unilamellar vesicle (GUV) composed of a lipid bilayer, the base structure of the cellular membrane, results in a functional cell‐sized structure that partially mimics some cellular functions. This review discusses the studies contributing to the construction of GUV‐based artificial molecular systems based on DNA nanotechnology. Molecular transport and signal transduction through lipid membranes are essential to uptake molecules from the environment and respond to stimuli. Membrane shaping relates to various functions, including motility and signaling. A chemical reaction network is required to autonomously regulate the system's functions. This review describes the functions realized using DNA nanostructures and DNA reaction networks. Given the designability and programmability of DNA nanotechnology, it may be possible that the functionality of artificial molecular systems could be comparable to or even surpass that of natural molecular systems.

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