Modulating Lineage Specification in Stem Cell Differentiation via Bioelectrical Stimulation Intensity Matching
Fengyi Zhang,
Xiangyu Yan,
Muyao Wu
et al.
Abstract:Development and regeneration in biological tissues are fundamentally affected by stem‐cell‐fate commitment. Bioelectricity is heterogeneous between different tissues and crucially regulates cell behaviors, including cell differentiation. However, the effects of heterogeneous bioelectricity on stem‐cell differentiation remain poorly understood. Herein, it is shown that providing stem cells with electrical stimulation matching the endogenous membrane potentials of cells derived from different tissues (osteogenic… Show more
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